N1-Heterocyclic pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 5, 2010, Pages 1585-1588

  Mitchell, Michael L ^a   Son, Jong Chan ^b   Lee, Ill Young ^b   Lee, Chong Kyo ^b   Kim, Hae Soo ^b   Guo, Hongyan ^a   Wang, Jianhong ^a   Hayes, Jaclyn ^a   Wang, Michael ^a   Paul, Amber ^a   Lansdon, Eric B ^a   Chen, James M ^a   Eisenberg, Gene ^a   Geleziunas, Romas ^a   Xu, Lianhong ^a   Kim, Choung U ^a  

^a GILEAD SCIENCES   (United States)

^b Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

Human immunodeficiency virus; Non nucleoside; Pyrimidinedione; Reverse transcriptase

Indexed keywords

3,5 DICHOLORO 2,4,6 TRIFLUOROPYRIDINE; ANTIRETROVIRUS AGENT; ASPARAGINE; EFAVIRENZ; ETRAVIRINE; FLUOROPYRIMIDINE DERIVATIVE; HYDROGEN; KRV 2110; LYSINE; MONOFLUOROPYRIDINE; N PYRIDINYL PYRIMIDINEDIONE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DOG; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; NONHUMAN; PHARMACOLOGICAL PARAMETERS; VIRUS MUTANT; VIRUS RESISTANCE;

ANIMALS; ANTI-HIV AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DOGS; HETEROCYCLIC COMPOUNDS; HIV REVERSE TRANSCRIPTASE; HUMANS; HYDROGEN BONDING; MICROSOMES; MUTANT PROTEINS; PYRIMIDINONES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THYMINE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 76649108538     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.086     Document Type: Article

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