Convenient synthesis of 4-amino-3,5-disubstituted pyrazoles in one step from the corresponding diketo oximes

Tetrahedron Letters

Volumn 45, Issue 10, 2004, Pages 2137-2139

  Majid, Tahir ^a   Hopkins, Corey R ^a   Pedgrift, Brian ^a   Collar, Nicola ^a  

^a SANOFI   (France)

Author keywords

Hydrazine hydrate; Pyrazole; Reduction

Indexed keywords

HYDRAZINE; NITROSO DERIVATIVE; OXIME DERIVATIVE; PYRAZOLE DERIVATIVE;

ARTICLE; CYCLIZATION; REDUCTION; SUBSTITUTION REACTION;

EID: 1242272922     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.01.045     Document Type: Article

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28. There were numerous uncharacterized side products formed in the reaction. However, the overall yield of 50% was still an improvement over the two-step protocol for this compound (40%).
29. The nitroso pyrazole compound was formed after 1 h (TLC and LCMS analysis).
30. 3O (187.20) MS (ESI) 188 (M+H).