Old age is associated with ultrastructural changes in isolated rat liver sinusoidal endothelial cells

Journal of Electron Microscopy

Volumn 59, Issue 1, 2010, Pages 65-69

  O'Reilly, Jennifer N ^a   Cogger, Victoria C ^a   Le Couteur, David G ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Aging; Fenestration; Sinusoidal endothelial cell

Indexed keywords

AGING; ANIMAL; ARTICLE; CELL CULTURE; ENDOTHELIUM CELL; FISCHER 344 RAT; IN VITRO STUDY; LIVER; MALE; PATHOLOGY; RAT; SCANNING ELECTRON MICROSCOPY; ULTRASTRUCTURE;

AGING; ANIMALS; CELLS, CULTURED; ENDOTHELIAL CELLS; LIVER; MALE; MICROSCOPY, ELECTRON, SCANNING; RATS; RATS, INBRED F344;

RATTUS;

CYTOLOGY; SCANNING ELECTRON MICROSCOPY;

AGE-RELATED CHANGES; CELL-BE; CELL/B.E; CELL/BE; FENESTRATION; LIVER SINUSOIDAL ENDOTHELIAL CELLS; OLD AGE; RAT LIVERS; SINUSOIDAL ENDOTHELIAL CELLS; ULTRASTRUCTURAL CHANGES;

ENDOTHELIAL CELLS;

EID: 76649098832     PISSN: 00220744     EISSN: 14779986     Source Type: Journal    
DOI: 10.1093/jmicro/dfp039     Document Type: Article

References (35)

1. Fraser R, Dobbs B R, and Rogers G W (1995) Lipoproteins and the liver sieve: the role of fenestrated sinusoidal endothelium in lipoprotein metabolism, atherosclerosis, and cirrhosis. Hepatology 21: 863-874.
2. Le Couteur D G, Fraser R, Hilmer S, Rivory L P, and McLean A J (2005) The hepatic sinusoid in aging and cirrhosis-effects on hepatic substrate disposition and drug clearance. Clin. Pharmacokinet. 44: 187-200.
3. Wisse W, De Zanger R B, Charels K, Van Der Smissen P, and McCuskey R S (1985) The liver sieve: considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse. Hepatology 5: 683-692.
4. Oda M, Tsukada N, Komatsu H, Kaneko K, Nakamura M, and Tsuchiya M (1986) Electron microscopic localizations of actin, calmodulin and calcium in the hepatic sinusoidal endothelium in the rat. In: Kirn A, Knook D L, and Wisse E (eds), Cells of the Hepatic Sinusoid, pp. 511-512 (Kupffer Cell Foundation, Rijswijk).
5. Arias I M (1990) The biology of hepatic endothelial cell fenestrae. Prog. Liver Dis. 9: 11-26.
6. Le Couteur D G, Cogger V C, Markus A M A, Harvey P J, Yin Z L, Ansselin A D, and McLean A J (2001) Pseudocapillarization and associated energy limitation in the aged rat liver. Hepatology 33: 537-543.
7. Cogger V C, Warren A, Fraser R, Ngu M, McLean A J, and Le Couteur D G (2003) Hepatic sinusoidal pseudocapillarization with aging in the non-human primate. Exp. Gerontol. 38: 1101-1107.
8. Ito Y, Sorensen K K, Bethea NW, Svistounov D, McCuskey M K, Smedsrod B H, and McCuskey R S (2007) Age-related changes in the hepatic microcirculation of mice. Exp. Gerontol. 48: 789-797.
9. Warren A, Bertolino P, Cogger V C, McLean A J, Fraser R, and Le Couteur D G (2005) Hepatic pseudocapillarization in aged mice. Exp. Gerontol. 40: 807-812.
10. Stacchiotti A, Lavazza A, Ferroni M, Sberveglieri G, Bianchi R, Rezzani R, and Rodella L F (2008) Effects of aluminium sulphate in the mouse liver: similarities to the aging process. Exp. Gerontol. 43: 330-338.
11. Le Couteur D G, Warren A, Cogger V C, Smedsrod B, Sorensen K, de Cabo R, Fraser R, and McCuskey R S (2008) Old age and the hepatic sinusoid. Anat. Rec. 291: 672-683.
12. Hilmer S N, Cogger V C, Fraser R, McLean A J, Sullivan D, and Le Couteur D G (2005) Age-related changes in the hepatic sinusoidal endothelium impede lipoprotein transfer in the rat. Hepatology 42: 1349-1354.
13. Le Couteur D G, Fraser R, Cogger V C, and McLean A J (2002) Hepatic pseudocapillarisation and atherosclerosis in ageing. Lancet 359: 1612-1615.
14. Le Couteur D G, Cogger V C, McCuskey R S, de Cabo R, Smedsrod B, Sorensen K K, Warren A, and Fraser R (2007) Age-related changes in the liver sinusoidal endothelium: a mechanism for dyslipidemia. Ann. N Y Acad. Sci. 1114: 79-87.
15. Cogger V C, Muller M, Fraser R, McLean A J, Khan J, and Le Couteur D G (2004) The effects of oxidative stress on the liver sieve. J. Hepatol. 41: 370-376.
16. Cogger V C, Hilmer S, Sullivan D, Muller M, Fraser R, and Le Couteur D G (2006) Surfactants and hyperlipidemia: the liver sieve is a link. Atherosclerosis 189: 273-281.
17. Dvorak A M, and Feng D (2001) The vesiculo-vacuolar organelle (VVO). A new endothelial cell permeability organelle. J. Histochem. Cytochem. 49: 419-432.
18. Ohata M, Tanuma Y, and Ito T (1984) A transmission electron microscopic study on sinusoidal cells of guinea pig liver, with special reference to the occurrence of a canalicular system and pored domes in the endothelium. Arch. Histol. Jpn. 47: 359-376.
19. Oda M, Yokomori H, and Han J Y (2003) Regulatory mechanisms of hepatic microcirculation. Clin. Hemorheol. Microcirc. 29: 167-182.
20. Elvevold K, Smedsrod B, and Martinez I (2008) The liver sinusoidal endothelial cell: a cell type of controversial and confusing identity. Am. J. Physiol. 294: G391-400.
21. Jamieson H, Hilmer S N, Cogger V C, Warren A, Cheluvappa R, Abernethy D R, Everitt A, Fraser R, de Cabo R, and Le Couteur D G (2007) Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid. Exp. Gerontol. 42: 374-378.
22. McLean A J, Cogger V C, Chong G C, Warren A, Markus A M, Dahlstrom J E, and Le Couteur D G (2003) Age-related pseudocapillarization of the human liver. J. Pathol. 200: 112-117.
23. Cogger V C, and Le Couteur D G (2009) Fenestrations in the liver sinusoidal endothelial cell. In: Arias I, Wolkoff A, Boyer J, Shafritz D, Fausto N, Alter H, and Cohen A (eds), The Liver: Biology and Pathobiology (5th ed), pp. 387-404 (John Wiley and Sons Ltd, Hokoben).
24. Mori T, Okanoue T, Sawa Y, Hori N, Ohta M, and Kagawa K (1993) Defenestration of the sinusoidal endothelial cell in a rat model of cirrhosis. Hepatology 17: 891-897.
25. Wisse E, De Zanger R B, Jacobs R, and McCuskey R S (1983) Scanning electron microscope observations on the structure of portal veins, sinusoids and central veins in rat liver. Scan. Electron Microsc. 1441-1452.
26. Montesano R, and Nicolescu P (1978) Fenestrations in endothelium of rat liver sinusoids revisited by freeze-fracture. Anat. Rec. 190: 861-870.
27. Shin Y C (1997) Revaluation on the types and pattern of distribution of sinusoidal fenestrations in the lobule of normal rat liver. Anat. Rec. 247: 206-213.
28. Fraser R, Bowler L M, Day W A, Dobbs B, Johnson H D, and Lee D (1980) High perfusion pressure damages the sieving ability of sinusoidal endothelium in rat livers. Br. J. Exp. Pathol. 61: 222-228.
29. Frenzel H, Kremer B, and Hucker H (1977) The liver sinusoids under various pathological conditions. A TEM and SEM study of rat liver after respiratory hypoxia, telecobalt irradiation and endotoxin application. In: Wisse E and Knook D L (eds), Kupffer Cells and Other Liver Sinusoidal Cells, pp. 213-222 (Elsevier North-Holland Biomedical Press, Amsterdam).
30. Wright P L, Smith K F, Day W A, and Fraser R (1983) Hepatic sinusoidal endothelium in sheep: an ultrastructural reinvestigation. Anat. Rec. 206: 385-390.
31. March S, Hui E E, Underhill G H, Khetani S, and Bhatia S N (2009) Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro. Hepatology. Epub ahead of print 20 May 2009.
32. McGuire R F, Bissell D M, Boyles J, and Roll F J (1992) Role of extracellular matrix in regulating fenestrations of sinusoidal endothelial cells isolated from normal rat liver. Hepatology 15: 989-997.
33. Yokomori H, Oda M, Yoshimura K, Nagai T, Fujimaki K, Watanabe S, and Hibi T (2009) Caveolin-1 and Rac regulate endothelial capillary-like tubular formation and fenestral contraction in sinusoidal endothelial cells. Liver Int. 29: 266-276.
34. Martinez I, Nedredal G I, Oie C I, Warren A, Johansen O, Le Couteur D G, and Smedsrod B (2008) The influence of oxygen tension on the structure and function of isolated liver sinusoidal endothelial cells. Comp. Hepatol. 7: 4-15.
35. Young-Chul S (1997) Revaluation on the types and pattern of distribution of sinusoidal fenestrations in the lobule of normal rat liver. Anat. Rec. 247: 206-213.