Inhaled cyclosporine and pulmonary function in lung transplant recipients

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Volumn 23, Issue 1, 2010, Pages 31-39

  Groves, Soleyah ^a   Galazka, Marek ^a   Johnson, Bruce ^b   Corcoran, Timothy ^b   Verceles, Avelino ^a   Britt, Edward ^a   Todd, Nevins ^a   Griffith, Bartley ^a   Smaldone, Gerald C ^c   Iacono, Aldo ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

Bronchiolitis obliterans; Chronic rejection; Inhaled cyclosporine; Lung transplant; Pulmonary function

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN A; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PLACEBO; PREDNISONE; TACROLIMUS; THYMOCYTE ANTIBODY;

ADULT; AEROSOL; ARTICLE; BRONCHIOLITIS OBLITERANS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOMEGALOVIRUS; DATA BASE; DOUBLE BLIND PROCEDURE; FEMALE; FORCED EXPIRATORY VOLUME; GRAFT RECIPIENT; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LUNG FUNCTION; LUNG GRAFT REJECTION; LUNG TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PATIENT COMPLIANCE; RANDOMIZED CONTROLLED TRIAL;

ADMINISTRATION, INHALATION; ADULT; CYCLOSPORINE; FEMALE; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LUNG TRANSPLANTATION; MALE; MIDDLE AGED; RESPIRATORY FUNCTION TESTS; TREATMENT OUTCOME;

EID: 76649097976     PISSN: 19412711     EISSN: 19412703     Source Type: Journal    
DOI: 10.1089/jamp.2009.0748     Document Type: Article

References (24)

1. Lin H, Kauffman M, McBride M, Davies D, Rosendale J, Smith C, Edwards E, Daily P, Kirklin J, Shield C, Hunsicker L: Center-specific graft and patient survival rates. JAMA. 1998;280:1153-1160.
2. Trulock EP: Management of lung transplant rejection. Chest. 1993;103:1566-1576.
3. Estenne M, Maurer J, Boehler A, Egan J, Frost A, Hertz M, Mallory G, Snell G, Yousem S: Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria. J Heart Lung Transplant. 2002;21:297-310.
4. Duncan S, Leonard C, Theodore J, Lega M, Girgis R, Rosen G, Theofilopoulos A: Oligoclonal CD4+ T cell expansions in lung transplant recipients with obliterative bronchiolitis. Am J Respir Crit Care Med. 2002;165:1439-1444.
5. Duncan S, Valentine V, Roglic M, Elias D, Pekny K, Theodore J, Kono D, Theofilopoulos A: T cell receptor biases and clonal proliferations among lung transplant recipients with obliterative bronchiolitis. J Clin Invest. 1996; 97:2642-2650.
6. Tikkanen JM, Lemstrom KB, Kkoskinen PK: Blockade of CD28//B7-2 costimulation inhibits experimental obliterative bronchiolitis in rat tracheal allografts. Am J Respir Crit Care Med. 2002;165:724-729.
7. Di Padova FE: Pharmacology of cyclosporine (sandimmune). V. Pharmacological effects on immune function: in vitro studies. Pharmacol Rev. 1990;41:373-405.
8. Iacono AT, Corcoran TE, Griffith BP, Grgurich W, Smith D, Zeevi A, Smaldone G, McCurry K, Johnson B, Dauber J: Aerosol cyclosporine therapy in lung transplant recipients with bronchiolitis obliterans. Eur Respir J. 2004;23:384-390.
9. Muggenberg BA, Hoover MD, Griffith BP: Administration of cyclosporine by inhalation: a feasibility study in beagle dogs. J Aersol Med. 1990;3:1-6.
10. Dowling RD, Zenati M, Burckart GJ, Yousem S, Schaper M, Simmons R, Hardesty R, Griffith B: Aersolized cyclosporine as single-agent immunotherapy in canine lung allografts. Surgery. 1990;108:198-204.
11. Keenan RJ, Duncan AJ, Yousem SA, Zenati M, Schaper M, Dowling R, Alarie Y, Burckart G, Griffith B: Improved immunosuppression with aerosolized cyclosporine in experimental pulmonary transplantation. Transplantation. 1992;53: 20-25.
12. Iacono AT, Johnson BA, Grgurich WF, Youssef J, Corcoran T, Seiler D, Dauber J, Smaldone G, Zeevi A, Yousem S, Fung J, Burckart G, McCurry K, Griffith B: A randomized trial of inhaled cyclosporine in lung-transplant recipients. N Engl J Med. 2006;354:141-150.
13. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten C, Gustafsson P, Jensen R, Johnson D, MacIntyre N, McKay R, Navajas D, Pederson O, Pellegrino R, Viegi G, Wanger J, ATS//ERS Task Force: Standardisation of spirometry. Eur Respir J. 2005;26: 319-338.
14. Trulock EP: Lung transplantation. Am J Respir Crit Care Med. 1997;155:789-818.
15. Paradis I, Yousem S, Griffith B: Airway obstruction and bronchiolitis obliterans after lung transplantation. Clin Chest Med. 1993;14:751-763.
16. Christie JD, Edwards LB, Aurora P, Dobbels F, Kirk R, Rahmel A, Taylor D, Kucheryavaya A, Hertz M: Registry of the International Society for Heart and Lung Transplantation: Twenty-fifth Official Adult Lung and Heart//Lung Transplantation Report-2008. 2008;9:951-969.
17. Boehler A, Estenne M: Post-transplant bronchiolitis obliterans. Eur Respir J. 2003;22:1007-1018.
18. Hachem RR, Yusen RD, Chakinala MM, Meyers B, Lynch J, Aloush A, Patterson G, Trulock E: A randomized controlled trial of tacrolimus versus cyclosporine after lung transplantation. J Heart Lung Transplant. 2007;26:1012-1018.
19. Keenan RJ, Konishi H, Kawai A, Paradis I, Nunley D, Iacono A, Hardesty R, Weyant R, Griffith B: Clinical trial of tacrolimus versus cyclosporine in lung transplantation. Ann Thorac Surg. 1995;60:580-585.
20. Zuckermann A, Reichenspurner H, Birsan T, Treede H, Deviatko E, Reichart B, Klepetko W: Cyclosporine A versus tacrolimus in combination with mycophenolate mofetil and steroids as primary immunosuppression after lung transplantation: one-year results of a 2-center prospective randomized trial. J Thorac Cardiovasc Surg. 2003;125:891-900.
21. Treede H, Klepetko W, Reichenspurner H, Zuckermann A, Meiser B, Birsan T, Wisser W, Reichert B, Munich and Vienna Lung Transplant Group: Tacrolimus versus cyclosporine after lung transplantation: a prospective, open, randomized two-center trial comparing two different immunosuppressive protocols. J Heart Lung Transplant. 2001;20:511-517.
22. Iacono AT, Smaldone GC, Keenan RJ, Diot P, Dauber JH, Zeevi A, Burckart GJ, Griffith BP: Dose-related reversal of acute lung rejection by aerosolized cyclosporine. Am J Respir Crit Care Med. 1997;155:1690-1698.
23. Iacono AT, Corcoran TE, Griffith BP, Grgurich WF, Smith DA, Zeevi A, Smaldone GC, McCurry KR, Johnson BA, Dauber JH: Aerosol cyclosporine therapy in lung transplant recipients with bronchiolitis obliterans. Eur Respir J. 2004;23: 384-390.
24. Corcoran TE, Smaldone GC, Dauber JH, Smith DA, McCurry KR, Burckart GJ, Zeevi A, Griffith BP, Iacono AT: Preservation of post-transplant lung function with aerosol cyclosporine. Eur Respir J. 2004;23:378-383