Podophyllotoxin analogues active versus Trypanosoma brucei

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 5, 2010, Pages 1787-1791

  Uddin, Md Jashim ^a   Smithson, David C ^b,c   Brown, Kristin M ^b   Crews, Brenda C ^a   Connelly, Michele ^b   Zhu, Fangyi ^b   Marnett, Lawrence J ^a   Guy, R Kiplin ^b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Microtubule; Sleeping sickness; Trypanosoma brucei

Indexed keywords

CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; INDOMETACIN; NANOMATERIAL; PODOPHYLLOTOXIN DERIVATIVE; RHIZOXIN; TUBULIN;

AFRICAN TRYPANOSOMIASIS; ARTICLE; CELL LINE; CYTOSTASIS; DEPOLYMERIZATION; DRUG ACTIVITY; HUMAN; HUMAN CELL; HYDROPHOBICITY; MICROTUBULE ASSEMBLY; NONHUMAN; STATISTICAL SIGNIFICANCE; TRYPANOSOMA BRUCEI;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; HUMANS; INDOMETHACIN; PODOPHYLLOTOXIN; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI;

TRYPANOSOMA BRUCEI;

EID: 76649095637     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.009     Document Type: Article

References (13)

1. WHO. Fact Sheet, Vol. 2007, World Health Organization Media Centre, 2006.
2. Barrett M.P., Boykin D.W., Brun R., and Tidwell R.R. Br. J. Pharmacol. 152 (2007) 1155
3. Brun R., Schumacher R., Schmid C., Kunz C., and Burri C. Trop. Med. Int. Health 6 (2001) 906
4. Konkle M.E., Hargrove T.Y., Kleshchenko Y.Y., von Kries J.P., Ridenour W., Uddin M.J., Caprioli R.M., Marnett L.J., Nes W.D., Villalta F., Waterman M.R., and Lepesheva G.I. J. Med. Chem. 52 (2009) 2846
5. Lepesheva G.I., Zaitseva N.G., Nes W.D., Zhou W., Arase M., Liu J., Hill G.C., and Waterman M.R. J. Biol. Chem. 281 (2006) 3577
6. Lepesheva G.I., Ott R.D., Hargrove T.Y., Kleshchenko Y.Y., Schuster I., Nes W.D., Hill G.C., Villalta F., and Waterman M.R. Chem. Biol. 14 (2007) 1283
7. Lepesheva G.I., Hargrove T.Y., Ott R.D., Nes W.D., and Waterman M.R. Biochem. Soc. Trans. 34 (2006) 1161
8. Ploubidou A., Robinson D.R., Docherty R.C., Ogbadoyi E.O., and Gull K. J. Cell Sci. 112 (1999) 4641
9. Wilson L., and Meza I. J. Cell Biol. 58 (1973) 709
10. Murakami M., and Kudo I. Prog. Lipid Res. 43 (2004) 3
11. Kubata B.K., Duszenko M., Kabututu Z., Rawer M., Szallies A., Fujimori K., Inui T., Nozaki T., Yamashita K., Horii T., Urade Y., and Hayaishi O. J. Exp. Med. 192 (2000) 1327
12. Coppens I., Baudhuin P., Opperdoes F.R., and Courtoy P.J. Proc. Natl. Acad. Sci. U.S.A. 85 (1988) 6753
13. Grunfelder C.G., Engstler M., Weise F., Schwarz H., Stierhof Y.D., Morgan G.W., Field M.C., and Overath P. Mol. Biol. Cell 14 (2003) 2029