Production of emodin from Aspergillus ochraceus at preparative scale

African Journal of Biotechnology

Volumn 9, Issue 4, 2010, Pages 512-517

  Lu, Ping ^a   Zhao, Xueming ^a   Cui, Taian ^b  

^a TIANJIN UNIVERSITY   (China)

^b SINGAPORE POLYTECHNIC   (Singapore)

Author keywords

Aspergillus ochraceus; Emodin; Preparative liquid chromatography; Solid phase extraction

Indexed keywords

EMODIN;

ARTICLE; ASPERGILLUS OCHRACEUS; CONTROLLED STUDY; CULTURE MEDIUM; CULTURE TECHNIQUE; DRUG ISOLATION; DRUG STRUCTURE; DRY MASS; FERMENTATION; FRACTIONATION; LARGE SCALE PRODUCTION; LIQUID CHROMATOGRAPHY; NONHUMAN; PH; SOLID PHASE EXTRACTION;

ASPERGILLUS OCHRACEUS;

EID: 76649092368     PISSN: None     EISSN: 16845315     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Izhaki I (2002). Emodin-a secondary metablosite with multiple ecological functions in higher plants. New Phytologist. 55: 205-217.
2. Kaneshiro T, Morioka T, Inamine M, Kinjo T, Arakaki J, Chiba I, Sunagawa N, Suzui M, Yoshimi N (2006). Anthraquinone derivative emodin inhibits tumor-associated angiogenesis through inhibition of extracellular signal-regulated kinase 1/2 phosphorylation. Eur. J. Pharmacol. 553: 46-53.
3. Lin SY, Lai WW, Ho CC, Yu FS, Chen GW, Yang JS, Liu KC, Lin ML, Wu PP, Fan MJ, Chung JG (2009). Emodin induces apoptosis of human tongue squamous cancer SCC-4 cells through reactive oxygen species and mitochondria-dependent pathways. Anticancer Res. 29: 327-335.
4. Lu HM, Ni WD, Liang YZ, Man RL (2006). Supercritical CO2 extraction of emodin and physcion from Polygonum cuspidatum and subsequent isolation by semipreparative chromatography. J. Sep. Sci. 29: 2136-2142.
5. Muto A, Hori M, Sasaki Y, Saitoh A, Yasuda I, Maekawa T, Uchida T, Asakura K, Nakazato T, Kaneda T, Kizaki M, Ikeda Y, Yoshida T (2007). Emodin has a cytotoxic activity against human multiple myeloma as a Janus-activated kinase 2 inhibitor. Mol. Cancer Ther. 6: 987-994.
6. Srinvas G, Babykutty S, Sathiadevan PP, Srinivas P (2007). Molecular mechanism of emodin action: transition from laxative ingredient to an antitumor agent. Med. Res. Rev. 27: 591-608.
7. Wang JX, Xiao XH, Li GK (2008). Study of vacuum microwave-assisted extraction of polyphenolic compounds and pigment from Chinese herbs. J. Chromatogr. A 1198-1199: 45-53.
8. Wang L, Li D, Bao C, You J, Wang Z, Shi Y, Zhang H (2008). Ultrasonic extraction and separation of anthraquinones from Rheum palmatum L. Ultrason Sonochem. 15: 738-746.
9. Wells JM, Cole RJ, Kirksey JW (1975). Emodin, a toxic metabolite of Aspergillus wentii isolated from weevil-damaged chestnuts. Appl. Microbiol. 30: 26-28.
10. Yamazaki M, Maebayashi Y, Miyaki K (1970). Production of ochratoxin A by Aspergillus ochraceus isolated in Japan from moldy rice. Appl. Microbiol. 20: 452-454.
11. Zhang HX, Liu MC (2004). Separation procedures for the pharmacologically active components of rhubarb. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 812: 175-181.
12. Zhang L, Lau YK, Xia W, Hortobagyi GN, Hung MC (1999). Tyrosine kinase inhibitor emodin suppresses growth of HER-2/neuoverexpressing breast cancer cells in athymic mice and sensitizes these cells to the inhibitory effect of paclitaxel. Clin. Cancer Res. 5: 343-353.