Absolute configurations of tubulin inhibitors taltobulin (HTI-286) and HTI-042 characterized by X-ray diffraction analysis and NMR studies

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 5, 2010, Pages 1535-1538

  Niu, Chuansheng ^a   Ho, Douglas M ^b   Zask, Arie ^a   Ayral Kaloustian, Semiramis ^a  

^a WYETH RESEARCH   (United States)

^b PRINCETON UNIVERSITY   (United States)

Author keywords

DPFGSE 1D NOE; HTI 286; Tubulin inhibitors; X ray diffraction analysis

Indexed keywords

HTI 042; TALTOBULIN; TUBULIN; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL STRUCTURE; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT; STEREOCHEMISTRY; SYNTHESIS; X RAY DIFFRACTION;

CRYSTALLOGRAPHY, X-RAY; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; OLIGOPEPTIDES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUBULIN MODULATORS;

EID: 76649088953     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.047     Document Type: Article

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