Synthesis and biological activity of analogues of the antimicrotubule agent N,β,β-trimethyl-L-phenylalanyl-N1-[(1S,2E)-carboxy-1- isopropylbut-2-enyl]-N13-dimethyl-L-valinamide (HTI-286)

Journal of Medicinal Chemistry

Volumn 47, Issue 19, 2004, Pages 4774-4786

  Zask, Arie ^a   Birnberg, Gary ^a   Cheung, Katherine ^a   Kaplan, Joshua ^a   Niu, Chuan ^a   Norton, Emily ^a   Suayan, Ronald ^a   Yamashita, Ayako ^a   Cole, Derek ^a   Tang, Zhilian ^a   Krishnamurthy, Girija ^a   Williamson, Robert ^a   Khafizova, Gulnaz ^a   Musto, Sylvia ^a   Hernandez, Richard ^a   Annable, Tami ^a   Yang, Xiaoran ^a   Discafani, Carolyn ^a   Beyer, Carl ^a   Greenberger, Lee M ^a   Loganzo, Frank ^a   Ayral Kaloustian, Semiramis ^a   more..

^a WYETH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 METHOXYPHENYL DERIVATIVE; GLYCOPROTEIN P; HEMIASTERLIN; HEMIASTERLIN DERIVATIVE; HTI 042; N,BETA,BETA TRIMETHYLPHENYLALANYL N1 (3 CARBOXY 1 ISOPROPYLBUT 2 ENYL) N1,3 DIMETHYLVALINAMIDE; NATURAL PRODUCT; PACLITAXEL; TALTOBULIN; UNCLASSIFIED DRUG; VINCRISTINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; DEPOLYMERIZATION; DRUG ACTIVITY; DRUG EFFICACY; DRUG ISOLATION; DRUG POTENCY; DRUG POTENTIATION; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; MICROTUBULE ASSEMBLY; MICROTUBULE ORGANIZING CENTER; NONHUMAN; SPONGE (PORIFERA); STRUCTURE ACTIVITY RELATION;

AMINES; ANIMALS; CELL DEATH; CELL DIVISION; CELL LINE; CYCLIZATION; ESTERS; HUMANS; INHIBITORY CONCENTRATION 50; METHYLAMINES; MICE; MICROTUBULES; MOLECULAR STRUCTURE; NEOPLASMS; OLIGOPEPTIDES; OXIDATION-REDUCTION; PEPTIDES; PYRUVIC ACID; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN;

EID: 4444352764     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm040056u     Document Type: Article

References (34)

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