Effect of acute brain tyrosine depletion on MDMA-induced changes in brain 5-HT

Journal of Psychopharmacology

Volumn 24, Issue 2, 2010, Pages 267-274

  Rodsiri, R ^a   Green, A R ^a   Marsden, C A ^a   Fone, K C F ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

5 hydroxytryptamine; Dopamine; Hyperthermia; MDMA; Neurotoxicity; Rectal temperature; Tyrosine

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; DOPAMINE; PHENYLALANINE; SEROTONIN; TYROSINE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN LEVEL; BRAIN REGION; CONTROLLED STUDY; HYPERTHERMIA; MALE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; RECTUM TEMPERATURE; SEROTONIN RELEASE;

ANIMALS; CORPUS STRIATUM; DOPAMINE; FEVER; HIPPOCAMPUS; MALE; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; NEUROTOXICITY SYNDROMES; RATS; SEROTONIN; SEROTONIN AGENTS; TIME FACTORS; TYROSINE;

EID: 76649084906     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881109348163     Document Type: Article

References (27)

1. Biggio G., Porceddu ML, Geyer M. (1976) Decrease of homovanillic, dihydroxyphenylacetic acid and cyclic-adenosine-3'5'-monophosphate content in the rat caudate nucleus induced by the acute administration of an amino acid mixture lacking tyrosine and phenylalanine. J Neurochem 26: 1253-1255.
2. Bongiovanni R., Yamamoto BK, Jaskiw GE (2001) Improved method for the measurement of large neutral amino acids in biological matrices. J Chromatogr B Biomed Sci Appl 754: 369-376.
3. Breier JM, Bankson MG, Yamamoto BK (2006) L-tyrosine contributes to (+)-3,4-methylenedioxymethamphetamine-induced serotonin depletions. J Neurosci 26: 290-299.
4. Colado MI, Green AR (1994) A study of the mechanism of MDMA (ecstasy)-induced neurotoxicity of 5-HT neurones using chlormethiazole, dizocilpine and other protective compounds. Br J Pharmacol 111: 131-136.
5. Colado MI, OShea E., Granados R., Esteban B., Martin AB, Green AR (1999) Studies on the role of dopamine in the degeneration of 5-HT nerve endings in the brain of Dark Agouti rats following 3,4-methylenedioxymethamphetamine (MDMA or ecstasy) administration. Br J Pharmacol 126: 911-924.
6. Colado MI, Williams JL, Green AR (1995) The hyperthermic and neurotoxic effects of ecstasy (MDMA) and 3,4-methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype. Br J Pharmacol 115: 1281-1289.
7. de la Torre R., Puerta E., Aguirre N (2009) Comment on the letter by Green, Gabrielsson, Marsden, Fone, MDMA: on the translation from rodent to human dosing. Psychopharmacology 204: 379-380.
8. Easton N., Marsden CA (2006) Ecstasy: are animal data consistent between species and can they translate to humans ? J Psychopharmacol 20: 194-210.
9. Esteban E., OShea E., Camarero J., Sanchez V., Green AR, Colado MI (2001) 3,4-methylenedioxymethamphetamine induces monoamine release but not toxicity when administered centrally at a concentration occurring following a peripherally injected neurotoxic dose. Psychopharmacology 154: 251-260.
10. Fernstrom MH, Fernstrom JD (1995) Acute tyrosine depletion reduces tyrosine hydroxylation rate in rat central nervous system. Life Sci 57: 97-102.
11. Fernstrom JD, Wurtman RJ (1972) Brain serotonin content: physiological regulation by plasma neutral amino acids. Science 178: 414-416.
12. Go±i-Allo B., Puerta E., Math°na BO, et al. (2008) On the role of tyrosine and peripheral metabolism in 3,4-methylenedioxymethamphetamine- induced serotonin neurotoxicity in rats. Neuropharmacology 54: 885-900.
13. Gough B., Ali SF, Slikker W., Jr, Holson RR (1991) Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamines in rat caudate. Pharmacol Biochem Behav 39: 619-623.
14. Grahame-Smith DG, Parfitt A. (1970) Tryptophan transport across the synaptosomal membrane. J Neurochem 17: 1339-1353.
15. Green AR, Gabrielsson J., Marsden CA, Fone KCF (2009) MDMA: on the translation from rodent to human dosing. Psychopharmacology 204: 375-378.
16. Green AR, Mechan AO, Elliott JM, OShea E., Colado MI (2003) The pharmacology and clinical pharmacology of 3, 4-methylenedioxymethamphetamine (MDMA, ecstasy). Pharmacol Rev 55: 463-508.
17. Green AR, Sanchez V., OShea E., Saadat KS, Elliott JM, Colado MI (2004) Effect of ambient temperature and a prior neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA) on the hyperthermic response of rats to a single or repeated (binge ingestion) low dose of MDMA. Psychopharmacology 173: 264-269.
18. Greene SL, Dargan PI, OConnor N., Jones AL, Kerins M. (2003) Multiple toxicity from 3,4-methylenedioxymethamphetamine (ecstasy). Am J Emerg Med 21: 121-124.
19. Logan BJ, Laverty R., Sanderson WD, Yee YB (1988) Differences between rats and mice in MDMA (methylenedioxymethylamphetamine) neurotoxicity. Eur J Pharmacol 152: 227-234.
20. McTavish SF, Cowen PJ, Sharp T. (1999) Effect of a tyrosine-free amino acid mixture on regional brain catecholamine synthesis and release. Psychopharmacology 141: 182-188.
21. Mechan AO, Esteban B., OShea E., Elliott JM, Colado MI, Green AR (2002) The pharmacology of the acute hyperthermic response that follows administration of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) to rats. Br J Pharmacol 135: 170-180.
22. OShea E., Orio L., Escobedo I., et al. (2006) MDMA-induced neurotoxicity: long-term effects on 5-HT biosynthesis and the influence of ambient temperature. Br J Pharmacol 148: 778-785.
23. Schmidt CJ, Levin JA, Lovenberg W. (1987) In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain. Biochem Pharmacol 36: 747-755.
24. Schmidt CJ, Taylor VL, Abbate GM, Nieduzak TR (1991) 5-HT2 antagonists stereoselectively prevent the neurotoxicity of 3,4-methylenedioxymethamphetamine by blocking the acute stimulation of dopamine synthesis: reversal by L-dopa. J Pharmacol Exp Ther 256: 230-235.
25. Sprague JE, Everman SL, Nichols DE (1998) An integrated hypothesis for the serotonergic axonal loss induced by 3,4-methylenedioxymethamphetamine. Neurotoxicology 19: 427-441.
26. Yamamoto BK, Spanos LJ (1988) The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat. Eur J Pharmacol 148: 195-203.
27. Yuan J., Cord BJ, McCann UD, Callahan BT, Ricaurte GA (2002) Effect of depleting vesicular and cytoplasmic dopamine on methylenedioxymethamphetamine neurotoxicity. J Neurochem 80: 960-969.