Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: A basic science study

Arthritis Research and Therapy

Volumn 9, Issue 6, 2007, Pages

  Tat, Steeve Kwan ^a   Pelletier, Jean Pierre ^a   Vergés, Josep ^b   Lajeunesse, Daniel ^a   Montell, Eulàlia ^b   Fahmi, Hassan ^a   Lavigne, Martin ^c   Martel Pelletier, Johanne ^a  

^a NOTRE DAME HOSPITAL   (Canada)

^b BIOIBERICA SA   (Spain)

^c MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; BIOLOGICAL MARKER; CHONDROITIN SULFATE; COLECALCIFEROL; GLUCOSAMINE SULFATE; MESSENGER RNA; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; CALCITRIOL; GLUCOSAMINE; PRIMER DNA; TNFRSF11B PROTEIN, HUMAN; TNFSF11 PROTEIN, HUMAN; UNCLASSIFIED DRUG;

AGED; ARTICLE; BONE METABOLISM; BONE REMODELING; DRUG EFFICACY; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN TISSUE; OSTEOARTHRITIS; OSTEOBLAST; OSTEOLYSIS; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECT; DRUG POTENTIATION; GENETICS; METABOLISM; MIDDLE AGED; NUCLEOTIDE SEQUENCE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

AGED; ALKALINE PHOSPHATASE; BASE SEQUENCE; BIOLOGICAL MARKERS; BONE RESORPTION; CALCITRIOL; CELLS, CULTURED; CHONDROITIN SULFATES; DNA PRIMERS; DRUG SYNERGISM; GLUCOSAMINE; HUMANS; MIDDLE AGED; OSTEOARTHRITIS; OSTEOBLASTS; OSTEOCALCIN; OSTEOPROTEGERIN; RANK LIGAND; RNA, MESSENGER;

EID: 37848999867     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar2325     Document Type: Article

References (47)

1. Martel-Pelletier J Lajeunesse D Pelletier JP Etiopathogenesis of osteoarthritis Arthritis and Allied Conditions: A Textbook of Rheumatology Baltimore: Lippincott, Williams Wilkins Koopman WJ, Moreland LW 2005 2199 2226
2. Lajeunesse D Massicotte F Pelletier JP Martel-Pelletier J Subchondral bone sclerosis in osteoarthritis: Not just an innocent bystander Modern Rheumatology 2003, 13:7-14. 10.1007/s101650300001
3. Lippiello L Glucosamine and chondroitin sulfate: Biological response modifiers of chondrocytes under simulated conditions of joint stress Osteoarthritis Cartilage 2003, 11:335-342. 10.1016/S1063-4584(03)00026-8 12744939
4. McAlindon TE LaValley MP Gulin JP Felson DT Glucosamine and chondroitin for treatment of osteoarthritis: A systematic quality assessment and meta-analysis JAMA 2000, 283:1469-1475. 10.1001/jama.283.11.1469 10732937
5. Richy F Bruyere O Ethgen O Cucherat M Henrotin Y Reginster JY Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: A comprehensive meta-analysis Arch Intern Med 2003, 163:1514-1522. 10.1001/archinte.163.13.1514 12860572
6. Reginster JY Kahan A Vignon E A two-year prospective, randomized, double-blind, controlled study assessing the effect of chondroitin 4&6 sulfate (CS) on the structural progression of knee osteoarthritis: STOPP (STudy on osteoarthritis progression prevention) Arthritis Rheum 2006, 54(Suppl 93).
7. Clegg DO Reda DJ Harris CL Klein MA O'Dell JR Hooper MM Bradley JD Bingham CO 3rd Weisman MH Jackson CG Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis N Engl J Med 2006, 354:795-808. 10.1056/NEJMoa052771 16495392
8. Waddington RJ Roberts HC Sugars RV Schonherr E Differential roles for small leucine-rich proteoglycans in bone formation Eur Cell Mater 2003, 6:12-21. 14562268
9. Caterson B Mahmoodian F Sorrell JM Hardingham TE Bayliss MT Carney SL Ratcliffe A Muir H Modulation of native chondroitin sulphate structure in tissue development and in disease J Cell Sci 1990, 97:411-417. 1705939
10. Bettica P Cline G Hart DJ Meyer J Spector TD Evidence for increased bone resorption in patients with progressive knee osteoarthritis: longitudinal results from the Chingford study Arthritis Rheum 2002, 46:3178-3184. 10.1002/art.10630 12483721
11. Kwan Tat S Pelletier J-P Lajeunesse D Fahmi H Lavigne M Martel-Pelletier J The differential expression of osteoprotegerin (OPG) and receptor activator of nuclear factor κB ligand (RANKL) in human osteoarthritic subchondral bone osteoblasts is an indicator of the metabolic state of these disease cells Clin Exp Rheumatol
12. Massicotte F Lajeunesse D Benderdour M Pelletier J-P Hilal G Duval N Martel-Pelletier J Can altered production of interleukin 1β, interleukin-6, transforming growth factor-β and prostaglandin E2 by isolated human subchondral osteoblasts identify two subgroups of osteoarthritic patients Osteoarthritis Cartilage 2002, 10:491-500. 10.1053/joca.2002.0528 12056853
13. Massicotte F Fernandes JC Martel-Pelletier J Pelletier JP Lajeunesse D Modulation of insulin-like growth factor 1 levels in human osteoarthritic subchondral bone osteoblasts Bone 2006, 38:333-341. 10.1016/j.bone.2005.09.007 16257278
14. Couchourel D Aubry I Lavigne M Martel-Pelletier J Pelletier J-P Lajeunesse D Abnormal mineralization of human osteoarthritic osteoblasts is linked to abnormal production of collagen type 1 [abstract] Arthritis Rheum 2006, 54:S572.
15. Altman RD Asch E Bloch DA Bole G Borenstein D Brandt KD Christy W Cooke TD Greenwald R Hochberg M Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee Arthritis Rheum 1986, 29:1039-1049. 10.1002/art.1780290816 3741515
16. Hilal G Martel-Pelletier J Pelletier JP Ranger P Lajeunesse D Osteoblast-like cells from human subchondral osteoarthritic bone demonstrate an altered phenotype in vitro: Possible role in subchondral bone sclerosis Arthritis Rheum 1998, 41:891-899. 10.1002/ 1529-0131(199805)41:5<891::AID-ART17>3.0.CO;2-X 9588742
17. Hilal G Martel-Pelletier J Pelletier JP Duval N Lajeunesse D Abnormal regulation of urokinase plasminogen activator by insulin-like growth factor 1 in human osteoarthritic subchondral osteoblasts Arthritis Rheum 1999, 42:2112-2122. 10.1002/ 1529-0131(199910)42:10<2112::AID-ANR11>3.0.CO;2-N 10524682
18. Viereck V Siggelkow H Tauber S Raddatz D Schutze N Hufner M Differential regulation of Cbfa1/Runx2 and osteocalcin gene expression by vitamin-D3, dexamethasone, and local growth factors in primary human osteoblasts J Cell Biochem 2002, 86:348-356. 10.1002/jcb.10220 12112004
19. Shen J Hovhannisyan H Lian JB Montecino MA Stein GS Stein JL Van Wijnen AJ Transcriptional induction of the osteocalcin gene during osteoblast differentiation involves acetylation of histones h3 and h4 Mol Endocrinol 2003, 17:743-756. 10.1210/me.2002-0122 12554783
20. zur Nieden NI Kempka G Ahr HJ In vitro differentiation of embryonic stem cells into mineralized osteoblasts Differentiation 2003, 71:18-27. 10.1046/j.1432-0436.2003.700602.x 12558600
21. Cantatore FP Corrado A Grano M Quarta L Colucci S Melillo N Osteocalcin synthesis by human osteoblasts from normal and osteoarthritic bone after vitamin D3 stimulation Clin Rheumatol 2004, 23:490-495. 10.1007/ s10067-004-0928-1 15801068
22. Tardif G Hum D Pelletier JP Boileau C Ranger P Martel-Pelletier J Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts Arthritis Rheum 2004, 50:2521-2530. 10.1002/art.20441 15334466
23. Paredes Y Massicotte F Pelletier JP Martel-Pelletier J Laufer S Lajeunesse D Study of the role of leukotriene B4 in abnormal function of human subchondral osteoarthritis osteoblasts: Effects of cyclooxygenase and/or 5-lipoxygenase inhibition Arthritis Rheum 2002, 46:1804-1812. 10.1002/art.10357 12124864
24. Guévremont M Martel-Pelletier J Massicotte F Tardif G Pelletier JP Ranger P Lajeunesse D Reboul P Human adult chondrocytes express hepatocyte growth factor (HGF) isoforms but not HGF: Potential implication of osteoblasts on the presence of HGF in cartilage J Bone Miner Res 2003, 18:1073-1081. 10.1359/jbmr.2003.18.6.1073 12817761
25. Dempster DW Hughes-Begos CE Plavetic-Chee K Brandao-Burch A Cosman F Nieves J Neubort S Lu SS Iida-Klein A Arnett T Normal human osteoclasts formed from peripheral blood monocytes express PTH type 1 receptors and are stimulated by PTH in the absence of osteoblasts J Cell Biochem 2005, 95:139-148. 10.1002/jcb.20388 15723294
26. Bezerra MC Carvalho JF Prokopowitsch AS Pereira RM RANK, RANKL and osteoprotegerin in arthritic bone loss Braz J Med Biol Res 2005, 38:161-170. 10.1590/S0100-879X2005000200004 15785827
27. Reginster JY Bruyere O Lecart MP Henrotin Y Naturocetic (glucosamine and chondroitin sulfate) compounds as structure-modifying drugs in the treatment of osteoarthritis Curr Opin Rheumatol 2003, 15:651-655. 10.1097/00002281-200309000-00022 12960496
28. Owens S Wagner P Vangsness CT Jr Recent advances in glucosamine and chondroitin supplementation J Knee Surg 2004, 17:185-193. 15553585
29. Simanek V Kren V Ulrichova J Gallo J The efficacy of glucosamine and chondroitin sulfate in the treatment of osteoarthritis: Are these saccharides drugs or nutraceuticals? Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2005, 149:51-56. 16170388
30. Theoleyre S Kwan Tat S Vusio P Blanchard F Gallagher J Ricard-Blum S Fortun Y Padrines M Redini F Heymann D Characterization of osteoprotegerin binding to glycosaminoglycans by surface plasmon resonance: Role in the interactions with receptor activator of nuclear factor kappaB ligand (RANKL) and RANK Biochem Biophys Res Commun 2006, 347:460-467. 10.1016/j.bbrc.2006.06.120 16828054
31. Tat SK Padrines M Theoleyre S Couillaud-Battaglia S Heymann D Redini F Fortun Y OPG/membranous-RANKL complex is internalized via the clathrin pathway before a lysosomal and a proteasomal degradation Bone 2006, 39:706-715. 10.1016/j.bone.2006.03.016 16750945
32. Dodge GR Jimenez SA Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes Osteoarthritis Cartilage 2003, 11:424-432. 10.1016/S1063-4584(03)00052-9 12801482
33. Itonaga I Sabokbar A Sun SG Kudo O Danks L Ferguson D Fujikawa Y Athanasou NA Transforming growth factor-beta induces osteoclast formation in the absence of RANKL Bone 2004, 34:57-64. 10.1016/ j.bone.2003.08.008 14751563
34. Sells Galvin RJ Gatlin CL Horn JW Fuson TR TGF-beta enhances osteoclast differentiation in hematopoietic cell cultures stimulated with RANKL and M-CSF Biochem Biophys Res Commun 1999, 265:233-239. 10.1006/ bbrc.1999.1632 10548519
35. Quinn JM Itoh K Udagawa N Hausler K Yasuda H Shima N Mizuno A Higashio K Takahashi N Suda T Transforming growth factor beta affects osteoclast differentiation via direct and indirect actions J Bone Miner Res 2001, 16:1787-1794. 10.1359/jbmr.2001.16.10.1787 11585342
36. Jimi E Akiyama S Tsurukai T Okahashi N Kobayashi K Udagawa N Nishihara T Takahashi N Suda T Osteoclast differentiation factor acts as a multifunctional regulator in murine osteoclast differentiation and function J Immunol 1999, 163:434-442. 10384146
37. Shikhman AR Kuhn K Alaaeddine N Lotz M N-acetylglucosamine prevents IL-1 beta-mediated activation of human chondrocytes J Immunol 2001, 166:5155-5160. 11290798
38. Gouze JN Bianchi A Becuwe P Dauca M Netter P Magdalou J Terlain B Bordji K Glucosamine modulates IL-1-induced activation of rat chondrocytes at a receptor level, and by inhibiting the NF-kappa B pathway FEBS Lett 2002, 510:166-170. 10.1016/S0014-5793(01)03255-0 11801247
39. Largo R Alvarez-Soria MA Diez-Ortego I Calvo E Sanchez-Pernaute O Egido J Herrero-Beaumont G Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes Osteoarthritis Cartilage 2003, 11:290-298. 10.1016/S1063-4584(03)00028-1 12681956
40. Atkins GJ Kostakis P Welldon KJ Vincent C Findlay DM Zannettino AC Human trabecular bone-derived osteoblasts support human osteoclast formation in vitro in a defined, serum-free medium J Cell Physiol 2005, 203:573-582. 10.1002/jcp.20255 15573398
41. Bergh JJ Xu Y Farach-Carson MC Osteoprotegerin expression and secretion are regulated by calcium influx through the L-type voltage-sensitive calcium channel Endocrinology 2004, 145:426-436. 10.1210/en.2003-0319 14525906
42. Tian QX Huang GY Effects of 1,25-dihydroxyvitamin D3 on the expressions of osteoprotegerin and receptor activator of NF-kappaB ligand in mouse osteoblasts Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2004, 26:418-422. 15379268
43. Itonaga I Sabokbar A Neale SD Athanasou NA 1,25-Dihydroxyvitamin D(3) and prostaglandin E(2) act directly on circulating human osteoclast precursors Biochem Biophys Res Commun 1999, 264:590-595. 10.1006/ bbrc.1999.1545 10529407
44. Hofbauer LC Dunstan CR Spelsberg TC Riggs BL Khosla S Osteoprotegerin production by human osteoblast lineage cells is stimulated by vitamin D, bone morphogenetic protein-2, and cytokines Biochem Biophys Res Commun 1998, 250:776-781. 10.1006/bbrc.1998.9394 9784422
45. Vidal ON Sjogren K Eriksson BI Ljunggren O Ohlsson C Osteoprotegerin mRNA is increased by interleukin-1 alpha in the human osteosarcoma cell line MG-63 and in human osteoblast-like cells Biochem Biophys Res Commun 1998, 248:696-700. 10.1006/bbrc.1998.9035 9703989
46. Brandstrom H Jonsson KB Ohlsson C Vidal O Ljunghall S Ljunggren O Regulation of osteoprotegerin mRNA levels by prostaglandin E2 in human bone marrow stroma cells Biochem Biophys Res Commun 1998, 247:338-341. 10.1006/bbrc.1998.8783 9642127
47. Thomas GP Baker SU Eisman JA Gardiner EM Changing RANKL/OPG mRNA expression in differentiating murine primary osteoblasts J Endocrinol 2001, 170:451-460. 10.1677/joe.0.1700451 11479141