Does PELOD measure organ dysfunction⋯and is organ function a valid surrogate for death?

Intensive Care Medicine

Volumn 36, Issue 1, 2010, Pages 4-7

  Tibby, Shane M ^a  

^a EVELINA LONDON CHILDREN S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOVASCULAR SYSTEM; DEATH; EDITORIAL; FUNCTIONAL ASSESSMENT; HUMAN; INTENSIVE CARE UNIT; MORTALITY; NEUROLOGY; QUALITATIVE ANALYSIS; QUALITY OF LIFE; SCORING SYSTEM; VALIDATION PROCESS;

ATTITUDE TO DEATH; CHILD; DATA INTERPRETATION, STATISTICAL; HUMANS; INTENSIVE CARE UNITS, PEDIATRIC; MULTIPLE ORGAN FAILURE; QUESTIONNAIRES;

EID: 76549127028     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-009-1712-0     Document Type: Editorial

References (28)

1. Paediatric Intensive Care Audit Network 2008 Fifth PICANet National Report. Accessed Oct 05 2009 at http://www.picanet.org.uk/documentation.html
2. A Slater F Shann ANZICS Paediatric Study Group 2004 The suitability of the pediatric index of mortality (PIM), PIM2, the pediatric risk of mortality (PRISM), and PRISM III for monitoring the quality of pediatric intensive care in Australia and New Zealand Pediatr Crit Care Med 5 447 454 10.1097/01.PCC. 0000138557.31831.65 15329160
3. MS Festa SM Tibby D Taylor A Durward P Habibi IA Murdoch 2005 Early application of generic mortality risk scores in presumed meningococcal disease Pediatr Crit Care Med 6 9 13 10.1097/01.PCC.0000149132.51906.13 15636652 (Pubitemid 40956462)
4. Roozenbeek B, Maas AI, Lingsma HF, Butcher I, Lu J, Marmarou A, McHugh GS, Weir J, Murray GD, Steyerberg EW, for the IMPACT Study Group (2009) Baseline characteristics and statistical power in randomized controlled trials: Selection, prognostic targeting, or covariate adjustment? Crit Care Med Aug 24 (Epub ahead of print)
5. Vincent JL, Opal SM, Marshall JC (2009) Ten reasons why we should NOT use severity scores as entry criteria for clinical trials or in our treatment decisions. Crit Care Med Aug 27 (Epub ahead of print)
6. I Ferreira-González JW Busse D Heels-Ansdell, et al. 2007 Problems with use of composite end points in cardiovascular trials: systematic review of randomised controlled trials BMJ 334 786 793 10.1136/bmj.39136.682083.AE 17403713 (Pubitemid 46650123)
7. G Colville 2008 The psychologic impact on children of admission to intensive care Pediatr Clin North Am 55 605 616 10.1016/j.pcl.2008.02.006 18501757 (Pubitemid 351697546)
8. No authors listed (1999) ICH Harmonised Tripartite Guideline. Statistical principles for clinical trials. International Conference on Harmonisation E9 Expert Working Group. Stat Med 18:1905-1942
9. JD Wilkinson MM Pollack UE Ruttimann NL Glass TS Yeh 1986 Outcome of pediatric patients with multiple organ system failure Crit Care Med 14 271 274 1:STN:280:DyaL287mtlejsA%3D%3D 3956214
10. F Proulx M Gauthier D Nadeau J Lacroix CA Farrell 1994 Timing and predictors of death in pediatric patients with multiple organ system failure Crit Care Med 22 1025 1031 10.1097/00003246-199406000-00023 1:STN:280: DyaK2c3msFCksg%3D%3D 8205810
11. JA Tantaleán RJ León AA Santos E Sánchez 2003 Multiple organ dysfunction syndrome in children Pediatr Crit Care Med 4 181 185 10.1097/01.PCC.0000059421.13161.88 12749649
12. B Goldstein B Giroir A Randolph International Consensus Conference on Pediatric Sepsis 2005 International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics Pediatr Crit Care Med 6 2 8 10.1097/01.PCC.0000149131.72248.E6 15636651 (Pubitemid 40956461)
13. MM Pollack KM Patel UE Ruttimann 1997 The pediatric risk of mortality III-acute physiology score (PRISM III-APS): a method of assessing physiologic instability for pediatric intensive care unit patients J Pediatr 131 575 581 10.1016/S0022-3476(97)70065-9 1:STN:280:DyaK1c%2FkslyqsQ%3D%3D 9386662 (Pubitemid 28006932)
14. S Leteurtre A Martinot A Duhamel F Gauvin B Grandbastien TV Nam F Proulx J Lacroix F Leclerc 1999 Development of a pediatric multiple organ dysfunction score: use of two strategies Med Decis Making 19 399 410 10.1177/ 0272989X9901900408 1:STN:280:DyaK1MvkvV2rug%3D%3D 10520678 (Pubitemid 29474766)
15. AL Graciano JA Balko DS Rahn N Ahmad BP Giroir 2005 The pediatric multiple organ dysfunction score (P-MODS): development and validation of an objective scale to measure the severity of multiple organ dysfunction in critically ill children Crit Care Med 33 1484 1491 10.1097/01.CCM.0000170943. 23633.47 16003052 (Pubitemid 40980602)
16. S Leteurtre A Martinot A Duhamel F Proulx B Grandbastien J Cotting R Gottesman A Joffe J Pfenninger P Hubert J Lacroix F Leclerc 2003 Validation of the paediatric logistic organ dysfunction (PELOD) score: prospective, observational, multicentre study Lancet 362 192 197 10.1016/S0140-6736(03)13908- 6 12885479 (Pubitemid 36859934)
17. S Leteurtre A Duhamel B Grandbastien J Lacroix F Leclerc 2006 Paediatric logistic organ dysfunction (PELOD) score Lancet 367 897 10.1016/S0140-6736(06) 68371-2 16546531
18. Garcia PC, Eulmesekian P, Branco RG, Perez A, Sffogia A, Olivero L, Piva JP, Tasker RC (2009) External validation of the paediatric logistic organ dysfunction score. Intensive Care Med. doi: 10.1007/s00134-009-1489-1
19. PC Garcia P Eulmesekian A Sffogia A Perez RG Branco JP Piva RC Tasker 2006 Limitation in paediatric logistic organ dysfunction score Lancet 368 1151 10.1016/S0140-6736(06)69464-6 17011936 (Pubitemid 44441570)
20. P Royston DG Altman W Sauerbrei 2006 Dichotomizing continuous predictors in multiple regression: a bad idea Stat Med 25 127 141 10.1002/sim.2331 16217841 (Pubitemid 43136953)
21. JC Marshall DJ Cook NV Christou GR Bernard CL Sprung WJ Sibbald 1995 Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome Crit Care Med 23 1638 1652 10.1097/00003246-199510000-00007 1:STN:280:DyaK28%2FhvFyrsA%3D%3D 7587228
22. JL Vincent R Moreno J Takala, et al. 1996 The SOFA (sepsis-related organ failure assessment) score to describe organ dysfunction/failure Intensive Care Med 22 707 710 10.1007/BF01709751 1:STN:280:DyaK2s%2FgtFantQ%3D%3D 8844239
23. Steyerberg E (2009) Clinical prediction models: a practical approach to development, validation, and updating. Springer, Germany
24. Royston P, Sauerbrei W (2008) Multivariable model-building. Wiley, Chichester, England
25. SG Baker BS Kramer 2003 A perfect correlate does not a surrogate make BMC Med Res Methodol 3 16 21 10.1186/1471-2288-3-16 12962545
26. VW Berger 2004 Does the Prentice criterion validate surrogate endpoints? Stat Med 23 1571 1578 10.1002/sim.1780 15122737 (Pubitemid 38660409)
27. Q Shi DJ Sargent 2009 Meta-analysis for the evaluation of surrogate endpoints in cancer clinical trials Int J Clin Oncol 14 102 111 10.1007/s10147-009-0885-4 19390940
28. M Singer V De Santis D Vitale W Jeffcoate 2004 Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation Lancet 364 545 548 10.1016/S0140-6736(04)16815-3 15302200 (Pubitemid 39070417)