MR diffusion and perfusion parameters: Relationship to metabolites in acute ischaemic stroke

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 81, Issue 2, 2010, Pages 185-191

  Cvoro, Vera ^a   Marshall, Ian ^a,c   Armitage, Paul A ^a,c   Bastin, Mark E ^a,c   Carpenter, Trevor ^a,c   Rivers, Carly S ^b   Dennis, Martin S ^a   Wardlaw, Joanna M ^a,c  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c SINAPSE Collaboration (Scottish Imaging Network A Platform for Scientific Excellence)   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LACTIC ACID; N ACETYLASPARTIC ACID;

ADULT; AGED; ANAEROBIC METABOLISM; ARTICLE; BRAIN PERFUSION; CEREBROVASCULAR ACCIDENT; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DIFFUSION COEFFICIENT; DIFFUSION TENSOR IMAGING; DIFFUSION WEIGHTED IMAGING; HUMAN; MAJOR CLINICAL STUDY; METABOLITE; NERVE CELL; NEUTRON ACTIVATION ANALYSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTON NUCLEAR MAGNETIC RESONANCE;

ADULT; AGED; AGED, 80 AND OVER; ASPARTIC ACID; BRAIN; BRAIN ISCHEMIA; CEREBROVASCULAR CIRCULATION; DIFFUSION MAGNETIC RESONANCE IMAGING; FEMALE; HUMANS; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX;

EID: 76549114935     PISSN: 00223050     EISSN: 1468330X     Source Type: Journal    
DOI: 10.1136/jnnp.2008.168393     Document Type: Article

References (43)

1. Sobesky J, Zaro WO, Lehnhardt FG, et al. Does the mismatch match the penumbra? Magnetic resonance imaging and positron emission tomography in early ischemic stroke. Stroke 2005;36:980-5.
2. Fiehler J. ADC and metabolites in stroke: even more confusion about diffusion? Stroke 2003;34:6-7.
3. Kane I, Sandercock P, Wardlaw J. Magnetic resonance perfusion diffusion mismatch and thrombolysis in acute ischaemic stroke: a systematic review of the evidence to date. J Neurol Neurosurg Psychiatry 2007;78:485-91.
4. Bandera E, Botteri M, Minelli C, et al. Cerebral blood flow threshold of ischemic penumbra and infarct core in acute ischemic stroke. A systematic review. Stroke 2006;37:1334-9.
5. Kane I, Carpenter T, Chappell F, et al. Comparison of 10 different magnetic resonance perfusion imaging processing methods in acute ischemic stroke. Effect on lesion size, proportion of patients with diffusion/perfusion mismatch, clinical scores, and radiologic outcomes. Stroke 2007;38:3158-64.
6. Sobesky J, Weber OZ, Lehnhardt FG, et al. Which time-to-peak threshold best identifies penumbral flow? A comparison of perfusion-weighted magnetic resonance imaging and positron emission tomography in acute ischemic stroke. Stroke 2004;35:2843-7.
7. Heiss WD, Sobesky J, Hesselmann V. Identifying thresholds for penumbra and irreversible tissue damage. Stroke 2004;35:2671-4.
8. Fiehler J, Foth M, Kucinski T, et al. Severe ADC decreases do not predict irreversible tissue damage in humans. Stroke 2002;33:79-86.
9. Loh PS, Butcher KS, Parsons MW, et al. Apparent diffusion coefficient thresholds do not predict the response to acute stroke thrombolysis. Stroke 2005;36:2626-31.
10. Na DG, Thijs VN, Albers GW, et al. Diffusion-weighted MR imaging in acute ischemia: value of apparent diffusion coefficient and signal intensity thresholds in predicting tissue at risk and final infarct size. Am J Neuroradiol 2004;25:1331-6.
11. Guadagno JV, Warburton EA, Jones PS, et al. The diffusion-weighted lesion in acute stroke: heterogeneous patterns of flow/metabolism uncoupling as assessed by quantitative positron emission tomography. Cerebrovasc Dis 2005;19:239-46.
12. Kidwell CS, Saver JL, Mattiello J, et al. Thrombolytic reversal of acute human cerebral ischemic injury shown by diffusion/perfusion magnetic resonance imaging. Ann Neurol 2000;47:462-9.
13. Monsein LH, Mathews VP, Barker PB, et al. Irreversible regional cerebral ischemia: serial MR imaging and proton MR spectroscopy in a non-human primate model. Am J Neuroradiol 2008;14:963-70.
14. Demougeot C, Marie C, Giroud M, et al. N-acetylaspartate: a literature review of animal research on brain ischemia. J Neurochem 2004;90:783.
15. Tsai G, Coyle JT. N-acetylaspartate in neuropsychiatric disorders. Prog Neurobiol 1995;46:540.
16. Labelle M, Khiat A, Durocher A, et al. Comparison of metabolite levels and water diffusion between cortical and subcortical strokes as monitored by MRI and MRS. Invest Radiol 2001;36:155-63.
17. Saunders DE, Howe FA, Van Der Boogaart A, et al. Continuing ischemic damage after acute middle cerebral artery infarction in humans demonstrated by short-echo proton spectroscopy. Stroke 1995;26:1007-13.
18. Sager TN, Hansen AJ, Laursen H. Correlation between N-acetylaspartate levels and histopathologic changes in cortical infarcts of mice after middle cerebral artery occlusion. J Cereb Blood Flow Metab 2000;20:780-8.
19. Sager TN, Laursen H, Hansen AJ. Changes in N-acetyl-aspartate content during focal and global brain ischemia of the rat. J Cereb Blood Flow Metab 1995;15:639-46.
20. Lemesle M, Walker P, Guy F, et al. Multi-variate analysis predicts clinical outcome 30 days after middle cerebral artery infarction. Acta Neurol Scand 2000;102:11-7.
21. Parsons MW, Li T, Barber PA, et al. Combined 1H MR spectroscopy and diffusionweighted MRI improves the prediction of stroke outcome. Neurology 2000;55:498-505.
22. Stengel A, Neumann-Haefelin T, Singer OC, et al. Multiple spin-echo spectroscopic imaging for rapid quantitative assessment of N-acetylaspartate and lactate in acute stroke. Magn Reson Med 2004;52:228-38.
23. Liu Y-J, Chen C-Y, Chung H-W, et al. Neuronal damage after ischemic injury in the middle cerebral arterial territory: deep watershed versus territorial infarction at MR perfusion and spectroscopic imaging. Radiology 2003;229:366-74.
24. Nicoli F, Lefur Y, Denis B, et al. Metabolic counterpart of decreased apparent diffusion coefficient during hyperacute ischemic stroke. A brain proton magnetic resonance spectroscopic imaging study. Stroke 2003;34:e82-8.
25. Parsons MW, Barber PA, Desmond PM, et al. Acute hyperglycemia adversely affects stroke outcome: a magnetic resonance imaging and spectroscopy study. Ann Neurol 2002;52:20-8.
26. Rumpel H, Khoo JB, Chang HM, et al. Correlation of the apparent diffusion coefficient and the creatine level in early ischemic stroke: a comparison of different patterns by magnetic resonance. J Magn Reson Imaging 2001;13:335-43.
27. Walker PM, Ben Salem D, Lalande A, et al. Time course of NAA T2 and ADC(w) in ischaemic stroke patients: 1H MRS imaging and diffusion-weighted MRI. J Neurol Sci 2004;220:23-8.
28. Bamford J, Sandercock P, Dennis M, et al. Classification and natural history of clinically identifiable subtypes of cerebral infarction. Lancet 1991;337:1521-6.
29. Carpenter T, Armitage PA, Bastin ME, et al. DSC perfusion MRI-quantification and reduction of systematic errors arising in areas of reduced cerebral blood flow. Magn Reson Med 2006;55:1342-9.
30. 1H magnetic resonance spectra. In: McWhirter JG, ed. Mathematics in signal processing III. Oxford: Clarendon Press, 1994:175-95.
31. Vanhamme L, van den BA, Van HS. Improved method for accurate and efficient quantification of MRS data with use of prior knowledge. J Magn Reson 1997;129:35-43.
32. van den Boogaart A, De Beer R, Van Hecke A, et al. MRUI: a graphical user interface for accurate routine MRS data analysis. Proceedings of the ESMRMB 13th Annual Meeting, Prague, 1996:318.
33. Karaszewski B, Wardlaw JM, Marshall I, et al. Measurement of brain temperature with magnetic resonance spectroscopy in acute ischaemic stroke. Ann Neurol 2006;60:438-46.
34. Rivers CS, Wardlaw JM. What has diffusion imaging in animals told us about diffusion imaging in patients with ischaemic stroke? Cerebrovasc Dis 2005;19:328-36.
35. Markus R, Reutens DC, Kazui S, et al. Spontaneous salvage of penumbral tissue improves clinical outcomes as late as 12-48 hr after stroke onset. Stroke 2004;35:295.
36. Muñoz Maniega S, Cvoro V, Armitage PA, et al. Choline and creatine are not reliable denominators for calculating metabolite ratios in acute ischemic stroke. Stroke 2008;39:2467-9.
37. Cvoro V, Wardlaw J, Marshall I, et al. Associations between diffusion and perfusion parameters, N-acetyl aspartate, and lactate in acute ischemic stroke. Stroke 2009;40:767-72.
38. Kucinski T, Vaterlein O, Glauche V, et al. Correlation of apparent diffusion coefficient and computed tomography density in acute ischemic stroke. Stroke 2002;33:1786-91.
39. Gillard JH, Barker PB, van Zijl PCM, et al. Proton MR spectroscopy in acute middle cerebral artery stroke. Am J Neuroradiol 1996;17:873-86.
40. Sijens PE, Den HT, deLeeuw FE, et al. MR spectroscopy detection of lactate and lipid signals in the brains of healthy elderly people. Eur Radiol 2001;11:1495-501.
41. Dzialowski I, Weber J, Doerfler A, et al. Brain tissue water uptake after middle cerebral artery occlusion assessed with CT. J Neuroimaging 2004;14:42-8.
42. Gideon P, Sperling B, Arlien-Soborg P, et al. Long-term follow-up of cerebral infarction patients with proton magnetic resonance spectroscopy. Stroke 1994;25:967-73.
43. Hand PJ, Wardlaw JM, Rivers CS, et al. MR diffusion-weighted imaging and outcome prediction after ischemic stroke. Neurology 2006;66:1159-63.