Upper airway function and arousability to ventilatory challenge in slow wave versus stage 2 sleep in obstructive sleep apnoea

Thorax

Volumn 65, Issue 2, 2010, Pages 107-112

  Ratnavadivel, Rajeev ^a,b   Stadler, Daniel ^a,c   Windler, Samantha ^a   Bradley, Jana ^a   Paul, Denzil ^a   McEvoy, R Douglas ^a,b,c   Catcheside, Peter G ^a,b,c  

^a REPATRIATION GENERAL HOSPITAL   (Australia)

^b FLINDERS UNIVERSITY   (Australia)

^c UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AIRWAY OBSTRUCTION; AROUSAL; ARTICLE; BREATHING; CATHETER; CLINICAL ARTICLE; CONTROLLED STUDY; FACE MASK; FEMALE; HUMAN; LUNG MINUTE VOLUME; MALE; PEAK EXPIRATORY FLOW; PNEUMOTACHYGRAPHY; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; PROVOCATION TEST; RESPIRATORY FUNCTION; SLEEP APNEA SYNDROME; SLEEP STAGE; SLOW WAVE SLEEP; UPPER RESPIRATORY TRACT;

EID: 76549112725     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thx.2008.112953     Document Type: Article

References (37)

1. Ratnavadivel R, Chau N, Stadler D, et al. Marked reduction in obstructive sleep apnea severity in slow wave sleep. J Clin Sleep Med 2009;5:519-24.
2. Berry RB, Asyali MA, McNellis MI, et al. Within-night variation in respiratory effort preceding apnea termination and EEG delta power in sleep apnea. J Appl Physiol 1998;85:1434-41.
3. Berry RB, Bonnet MH, Light RW. Effect of ethanol on the arousal response to airway occlusion during sleep in normal subjects. Am Rev Respir Dis 1992;145:445-52.
4. Lo YL, Jordan AS, Malhotra A, et al. Genioglossal muscle response to CO2 stimulation during NREM sleep. Sleep 2006;29:470- 7.
5. Stanchina ML, Malhotra A, Fogel RB, et al. Genioglossus muscle responsiveness to chemical and mechanical stimuli during non-rapid eye movement sleep. Am J Respir Crit Care Med 2002;165:945-9.
6. Younes M. Role of arousals in the pathogenesis of obstructive sleep apnea. Am J Respir Crit Care Med 2004;169:623-33.
7. Henke KG, Dempsey JA, Kowitz JM, et al. Effects of sleep-induced increases in upper airway resistance on ventilation. J Appl Physiol 1990;69:617-24.
8. Issa FG, Sullivan CE. Upper airway closing pressures in obstructive sleep apnea. J Appl Physiol 1984;57:520-7.
9. Penzel T, Moller M, Becker HF, et al. Effect of sleep position and sleep stage on the collapsibility of the upper airways in patients with sleep apnea. Sleep 2001;24:90-5.
10. Basner RC, Ringler J, Schwartzstein RM, et al. Phasic electromyographic activity of the genioglossus increases in normals during slow-wave sleep. Respir Physiol 1991;83:189-200.
11. Douglas NJ, White DP, Weil JV, et al. Hypercapnic ventilatory response in sleeping adults. Am Rev Respir Dis 1982;126:758-62.
12. Popovic RM, White DP. Upper airway muscle activity in normal women: influence of hormonal status. J Appl Physiol 1998;84:1055- 62.
13. Gleeson K, Zwillich CW, White DP. The influence of increasing ventilatory effort on arousal from sleep. Am Rev Respir Dis 1990;142:295-300.
14. Schwab RJ, Pasirstein M, Pierson R, et al. Identification of upper airway anatomic risk factors for obstructive sleep apnea with volumetric magnetic resonance imaging. Am J Respir Crit Care Med 2003;168:522-30.
15. Isono S, Remmers JE, Tanaka A, et al. Anatomy of pharynx in patients with obstructive sleep apnea and in normal subjects. J Appl Physiol 1997;82:1319-26.
16. Cartwright RD. Effect of sleep position on sleep apnea severity. Sleep 1984;7:110-4.
17. Cartwright RD, Diaz F, Lloyd S. The effects of sleep posture and sleep stage on apnea frequency. Sleep 1991;14:351-3.
18. Thut DC, Schwartz AR, Roach D, et al. Tracheal and neck position influence upper airway airflow dynamics by altering airway length. J Appl Physiol 1993;75:2084-90.
19. Younes M. Contributions of upper airway mechanics and control mechanisms to severity of obstructive apnea. Am J Respir Crit Care Med 2003;168:645-58.
20. Schwartz AR, O'Donnell CP, Baron J, et al. The hypotonic upper airway in obstructive sleep apnea: role of structures and neuromuscular activity. Am J Respir Crit Care Med 1998;157:1051-7.
21. Boudewyns A, Punjabi N, Van de Heyning PH, et al. Abbreviated method for assessing upper airway function in obstructive sleep apnea. Chest 2000;118:1031-41.
22. Patil SP, Punjabi NM, Schneider H, et al. A simplified method for measuring critical pressures during sleep in the clinical setting. Am J Respir Crit Care Med 2004;170:86-93.
23. Patil SP, Schneider H, Marx JJ, et al. Neuromechanical control of upper airway patency during sleep. J Appl Physiol 2007;102:547-56.
24. Catcheside PG, Orr RS, Chiong SC, et al. Mild hypoxia does not suppress auditory arousal from NREM sleep. Sleep 2006;29:619- 23.
25. Williams HL, Hammack JT, Daly RL, et al. Responses to auditory stimulation, sleep loss, and the EEG stages of sleep. Electroencephalogr Clin Neurophysiol 1964;16:269-79.
26. Berry RB, Gleeson K. Respiratory arousal from sleep: mechanisms and significance. Sleep 1997;20:654-75.
27. Zavodny J, Roth C, Bassetti CL, et al. Effects of sleep fragmentation on the arousability to resistive loading in NREM and REM sleep in normal men. Sleep 2006;29:525-32.
28. Hlavac MC, Catcheside PG, McDonald R, et al. Hypoxia impairs the arousal response to external resistive loading and airway occlusion during sleep. Sleep 2006;29:624-31.
29. Haba-Rubio J, Sforza E, Weiss T, et al. Effect of CPAP treatment on inspiratory arousal threshold during NREM sleep in OSAS. Sleep Breath 2005;9:12-9.
30. Berry RB, Kouchi KG, Der DE, et al. Sleep apnea impairs the arousal response to airway occlusion. Chest 1996;109:1490-6.
31. Khoo MC, Kronauer RE, Strohl KP, et al. Factors inducing periodic breathing in humans: a general model. J Appl Physiol 1982;53:644-59.
32. Younes M, Ostrowski M, Thompson W, et al. Chemical control stability in patients with obstructive sleep apnea. Am J Respir Crit Care Med 2001;163:1181-90.
33. Wellman A, Jordan AS, Malhotra A, et al. Ventilatory control and airway anatomy in obstructive sleep apnea. Am J Respir Crit Care Med 2004;170:1225-32.
34. EEG arousals: scoring rules and examples: a preliminary report from the Sleep Disorders Atlas Task Force of the American Sleep Disorders Association. Sleep 1992;15:173-84.
35. Jordan AS, Eckert DJ, Catcheside PG, et al. Ventilatory response to brief arousal from non-rapid eye movement sleep is greater in men than in women. Am J Respir Crit Care Med 2003;168:1512-9.
36. Fontvieille AM, Rising R, Spraul M, et al. Relationship between sleep stages and metabolic rate in humans. Am J Physiol 1994;267:E732-7.
37. White DP, Weil JV, Zwillich CW. Metabolic rate and breathing during sleep. J Appl Physiol 1985;59:384-91.