Development of relevant assay system to identify steroidogenic enzyme inhibitors

Toxicology in Vitro

Volumn 24, Issue 2, 2010, Pages 677-685

  Nishizato, Yohei ^a   Imai, Satoki ^a   Yabuki, Masashi ^a   Kido, Hidekatsu ^a   Komuro, Setsuko ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

Adrenal; Inhibitor; Ovary; Rat; Steroidogenic enzyme; Testis

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; AMINOGLUTETHIMIDE; AROMATASE; BIOCHANIN A; CHOLESTEROL ESTERASE; CYTOCHROME P450; CYTOCHROME P450 11A; CYTOCHROME P450 11B; CYTOCHROME P450 17; ECONAZOLE; ENZYME INHIBITOR; FLUFENAMIC ACID; HYDROXYSTEROID DEHYDROGENASE; KETOCONAZOLE; MEVINOLIN; MICONAZOLE; PHENYTOIN; SIMVASTATIN; STEROID; STEROID 21 MONOOXYGENASE; TROGLITAZONE; UNCLASSIFIED DRUG;

ADRENAL GLAND; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOSOL; ENDOCRINE DISEASE; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOMEOSTASIS; ISOTOPE LABELING; LYSOSOME; MALE; MITOCHONDRION; NONHUMAN; OVARY; RAT; SEPARATION TECHNIQUE; STEROIDOGENESIS; TESTIS;

ADRENAL GLANDS; ANIMALS; BUFFERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYDROGEN-ION CONCENTRATION; INHIBITORY CONCENTRATION 50; MALE; MOLECULAR STRUCTURE; OVARY; RATS; STEROIDS; SUBSTRATE SPECIFICITY; TESTIS;

RATTUS;

EID: 76549112492     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2009.07.037     Document Type: Article

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