Mitotic recombination and compound-heterozygous mutations are predominant NF1-inactivating mechanisms in children with juvenile myelomonocytic leukemia and neurofibromatosis type 1

Haematologica

Volumn 95, Issue 2, 2010, Pages 320-323

  Steinemann, Doris ^a   Arning, Larissa ^b   Praulich, Inka ^a   Stuhrmann, Manfred ^a   Hasle, Henrik ^c   Starý, Jan ^d   Schlegelberger, Brigitte ^a   Niemeyer, Charlotte M ^e   Flotho, Christian ^e  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

^d UNIVERSITY HOSPITAL MOTOL   (Czech Republic)

^e UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Juvenile myelomonocytic leukemia; Mitotic recombination; NF1 inactivating mechnisms

Indexed keywords

NEUROFIBROMIN;

ARTICLE; CHILD; CHROMOSOME 17Q; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; INFANT; JUVENILE MYELOMONOCYTIC LEUKEMIA; MALE; MITOTIC RECOMBINATION; NEUROFIBROMATOSIS; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRESCHOOL CHILD; SOMATIC MUTATION; UNIPARENTAL DISOMY;

CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; LEUKEMIA, MYELOMONOCYTIC, JUVENILE; LOSS OF HETEROZYGOSITY; MALE; MUTATION; NEUROFIBROMATOSIS 1; NEUROFIBROMIN 1; RECOMBINATION, GENETIC;

EID: 76549092856     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2009.010355     Document Type: Article

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