Pro-ulcer effects of resveratrol in mice with indomethacin-induced gastric ulcers are reversed by l-arginine: RESEARCH PAPER

British Journal of Pharmacology

Volumn 159, Issue 3, 2010, Pages 726-734

  Guha, P ^a   Dey, A ^a   Chatterjee, A ^a   Chattopadhyay, S ^b   Bandyopadhyay, S K ^a  

^a Department of Biochemistry   (India)

^b BHABHA ATOMIC RESEARCH CENTRE   (India)

Author keywords

eNOS; Gastric ulcer; l arginine; l NAME; NSAID; Resveratrol

Indexed keywords

ARGININE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDOMETACIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; MISOPROSTOL; MYELOPEROXIDASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PROSTAGLANDIN E2; RESVERATROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; DRUG EFFICACY; DRUG INHIBITION; ENZYME ACTIVITY; ENZYME SYNTHESIS; GENE EXPRESSION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; SCORING SYSTEM; SINGLE DRUG DOSE; STOMACH; STOMACH ULCER; ULCER HEALING;

ANIMALS; ANTINEOPLASTIC AGENTS; ARGININE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; INDOMETHACIN; MALE; MICE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; RNA, MESSENGER; STILBENES; STOMACH ULCER; ULCER; WOUND HEALING;

EID: 76449122383     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00572.x     Document Type: Article

References (24)

1. Alexander SPH, Mathie A, Peters JA (2008). Guide to Receptors and Channels (GRAC), 3rd edn. (2008 revision). Br J Pharmacol 153 (Suppl. 2 S1 S209.
2. Banerjee D, Bauri AK, Guha RK, Bandyopadhyay SK, Chattopadhyay S (2008). Healing properties of malabaricone B and malabaricone C, against indomethacin-induced gastric ulceration and mechanism of action. Eur J Pharmacol 578 : 300 312.
3. Bertelli AA, Giovannini L, Giannessi D, Migliori M, Bernini W, Fregoni M et al. (1995). Antiplatelet activity of synthetic and natural resveratrol in red wine. Int J Tissue React 17 : 1 3.
4. Bradley PP, Christensen RD, Rothstein G (1982). Cellular and extracellular myeloperoxidase in pyogenic inflammation. Blood 3 : 618 622.
5. Brzozowski T, Konturek PC, Konturek SJ, Sliwowski Z, Drozdowicz D, Stachura J et al. (1999). Cyclooxygenase-1 and cyclooxygenase-2 in healing of ischemia-reperfusion-induced gastric lesions. Eur J Pharmacol 385 : 47 61.
6. Brzozowski T, Konturek PC, Konturek SJ, Sliwowski Z, Pajdo R, Drozdowicz D et al. (2001). Classic NSAID and selective cyclooxygenase (COX)-1 and COX-2 inhibitors in healing of chronic gastric ulcers. Microsc Res Tech 53 : 343 353.
7. Das DK, Maulik N (2006). Resveratrol in cardioprotection: a therapeutic promise of alternative medicine. Mol Interv 6 : 36 47.
8. Dey A, Guha P, Chattopadhyay S, Bandyopadhyay SK (2009). Biphasic activity of resveratrol on indomethacin-induced gastric ulcers. Biochem Biophys Res Commun 381 : 90 95.
9. Dokmeci D, Akpolat M, Aydogu N, Doganay L, Turan FN (2005). l-Carnitine inhibits ethanol-induced gastric mucosal injury in rats. Pharmacol Rep 57 : 481 488.
10. Frankel EN, Waterhouse AL, Kinsella JE (1993). Inhibition of human LDL oxidation by resveratrol. Lancet 341 : 1103 1104.
11. Goldberg DM, Karumanchiri A, Yan J, Soleas G, Ng E, Waterhouse AL et al. (1995). A global survey of trans-resveratrol concentrations in commercial wines. Am J Enol Vitic 46 : 159 165.
12. Guha P, Dey A, Sarkar B, Dhyani MV, Chattopadhyay S, Bandyopadhyay SK (2009). Improved antiulcer and anticancer properties of a trans-resveratrol analog in mice. J Pharmacol Exp Ther 328 : 1 10.
13. Hain R, Bieseler B, Kindl H, Schroder G, Stocker R (1990). Expression of a stilbene synthase gene in Nicotiana tabacum results in synthesis of the phytoalexin resveratrol. Plant Mol Biol 15 : 325 335.
14. Hao HD, He LR (2004). Mechanisms of cardiovascular protection by resveratrol. J Med Food 7 : 290 298.
15. Hirose H, Takeuchi K, Okabe S (1991). Effect of indomethacin on gastric mucosal blood flow around acetic acid-induced gastric ulcers in rats. Gastroenterology 100 : 1259 1265.
16. Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW et al. (1997). Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275 : 218 220.
17. Ma L, Wallace JL (2000). Endothelial nitric oxide synthase modulates gastric ulcer healing in rats. Am J Physiol Gastrointest Liver Physiol 279 : 341 346.
18. Ma L, Yip J, Chow C, Cho CH (1999). Cigarette smoking delays ulcer healing: role of constitutive nitric oxide synthase in rat stomach. Am J Physiol Gastrointest Liver Physiol 276 : 238 248.
19. Martín AR, Villegas I, Sánchez-Hidalgo M, de la Lastra CA (2006). The effects of resveratrol, a phytoalexin derived from red wines, on chronic inflammation induced in an experimentally induced colitis model. Br J Pharm 147 : 873 885.
20. Miller TA (1983). Protective effects of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms. Am J Physiol 245 : G601 G623.
21. Siemann EH, Creasy LL (1992). Concentration of the phytoalexin resveratrol in wine. Am J Enol Vitic 43 : 49 52.
22. Souza MHLP, Lemos HP, Oliveira RB, Cunha FQ (2004). Gastric damage and granulocyte infiltration induced by indomethacin in tumour necrosis factor receptor 1 (TNF-R1) or inducible nitric oxide synthase (iNOS) deficient mice. Gut 53 : 791 796.
23. Subbaramaiah K, Chung WJ, Michaluart P, Telang N, Tanabe T, Inoue H et al. (1998). Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells. J Biol Chem 273 : 21875 21882. (Pubitemid 28405365)
24. Suzuki K, Ota H, Sasagawa S, Sakatani T, Fujikura T (1983). Assay method for myeloperoxidase in human polymorphonuclear leukocytes. Anal Biochem 132 : 345 352.