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Volumn 34, Issue 1, 2010, Pages 95-106

Deferoxamine versus combined therapy for chelating liver, spleen and bone marrow iron in β-thalassemic patients: A quantitative magnetic resonance imaging study

Author keywords

Bone marrow; Chelation; Iron; Liver; Magnetic resonance imaging (MRI); Spleen; Thalassemia

Indexed keywords

DEFERIPRONE; DEFEROXAMINE; FERRITIN;

EID: 76449107180     PISSN: 03630269     EISSN: 1532432X     Source Type: Journal    
DOI: 10.3109/03630260903546445     Document Type: Article
Times cited : (16)

References (37)
  • 1
    • 0014486517 scopus 로고
    • The pattern of disordered haemoglobin synthesis in homozygous and heterozygous b-thalassaemia
    • Weatherall DJ, Clegg JB, Na-Nakorn S, Wasi P. The pattern of disordered haemoglobin synthesis in homozygous and heterozygous b-thalassaemia. Br J Haematol. 1969;16(3):251-267.
    • (1969) Br J Haematol , vol.16 , Issue.3 , pp. 251-267
    • Weatherall, D.J.1    Clegg, J.B.2    Na-Nakorn, S.3    Wasi, P.4
  • 2
    • 0025843474 scopus 로고
    • Parenchymal versus reticuloendothelial iron overload in the liver: Distinction with MR imaging
    • Siegelman ES, Mitchell DG, Rubin R, et al. Parenchymal versus reticuloendothelial iron overload in the liver: distinction with MR imaging. Radiology. 1991;179(3):361-366.
    • (1991) Radiology , vol.179 , Issue.3 , pp. 361-366
    • Siegelman, E.S.1    Mitchell, D.G.2    Rubin, R.3
  • 4
    • 0027945442 scopus 로고
    • Hemochromatosis: Diagnosis and quantification of liver iron with gradient echo MR imaging
    • Gandon Y, Guyader D, Heautot JF, et al. Hemochromatosis: diagnosis and quantification of liver iron with gradient echo MR imaging. Radiology. 1994;193(2):533-538.
    • (1994) Radiology , vol.193 , Issue.2 , pp. 533-538
    • Gandon, Y.1    Guyader, D.2    Heautot, J.F.3
  • 5
    • 0842283228 scopus 로고    scopus 로고
    • Non-invasive assessment of hepatic iron stores by MRI
    • Gandon Y, Olivie D, Guyader D, et al. Non-invasive assessment of hepatic iron stores by MRI. Lancet. 2004; 363(9406):357-362.
    • (2004) Lancet , vol.363 , Issue.9406 , pp. 357-362
    • Gandon, Y.1    Olivie, D.2    Guyader, D.3
  • 6
    • 0028821746 scopus 로고
    • Assessment of liver iron overload by T2-quantitative magnetic resonance imaging: Correlation of T2-QMRI measurements with serum ferritin concentration and histologic grading of siderosis
    • Papakonstantinou OG, Maris TG, Kostaridou V, et al. Assessment of liver iron overload by T2-quantitative magnetic resonance imaging: correlation of T2-QMRI measurements with serum ferritin concentration and histologic grading of siderosis. Magn Reson Imaging. 1995;13(7):967-977.
    • (1995) Magn Reson Imaging , vol.13 , Issue.7 , pp. 967-977
    • Papakonstantinou, O.G.1    Maris, T.G.2    Kostaridou, V.3
  • 7
    • 0037964274 scopus 로고    scopus 로고
    • Comparison between signal-to-noise ratio, liver-to-muscle ratio, and 1/T2 for the noninvasive assessment of liver iron content by MRI
    • Fenzi A, Bortolazzi M, Marzola P. Comparison between signal-to-noise ratio, liver-to-muscle ratio, and 1/T2 for the noninvasive assessment of liver iron content by MRI. J Magn Reson Imaging. 2003;17(5):589-592.
    • (2003) J Magn Reson Imaging , vol.17 , Issue.5 , pp. 589-592
    • Fenzi, A.1    Bortolazzi, M.2    Marzola, P.3
  • 9
    • 0033042948 scopus 로고    scopus 로고
    • MR imaging of pancreatic changes in patients with transfusion-dependent b-thalassemia major
    • Midiri M, Lo Casto A, Sparacia G, et al. MR imaging of pancreatic changes in patients with transfusion- dependent b-thalassemia major. Am J Roentgenol. 1999;173(1):187-192.
    • (1999) Am J Roentgenol , vol.173 , Issue.1 , pp. 187-192
    • Midiri, M.1    Lo Casto, A.2    Sparacia, G.3
  • 10
    • 31544477163 scopus 로고    scopus 로고
    • Adrenal glands in b-thalassemia major: Magnetic resonance (MR) imaging features and correlation with iron stores
    • Drakonaki E, Papakonstantinou O, Maris T, Vasiliadou A, Papadakis A, Gourtsoyiannis N. Adrenal glands in b-thalassemia major: magnetic resonance (MR) imaging features and correlation with iron stores. Eur Radiol. 2005;15(12):2462-2468.
    • (2005) Eur Radiol , vol.15 , Issue.12 , pp. 2462-2468
    • Drakonaki, E.1    Papakonstantinou, O.2    Maris, T.3    Vasiliadou, A.4    Papadakis, A.5    Gourtsoyiannis, N.6
  • 11
    • 24644450586 scopus 로고    scopus 로고
    • Abdominal lymphadenopathy in b-thalassemia: MRI features and correlation with liver iron overload and posttransfusion chronic hepatitis C
    • Papakonstantinou O, Maris TG, Kostaridou S, Ladis V, Vasiliadou A, Gourtsoyiannis NC. Abdominal lymphadenopathy in b-thalassemia: MRI features and correlation with liver iron overload and posttransfusion chronic hepatitis C. Am J Roentgenol. 2005;185(1):219-224.
    • (2005) Am J Roentgenol , vol.185 , Issue.1 , pp. 219-224
    • Papakonstantinou, O.1    Maris, T.G.2    Kostaridou, S.3    Ladis, V.4    Vasiliadou, A.5    Gourtsoyiannis, N.C.6
  • 12
    • 39349096186 scopus 로고    scopus 로고
    • Long term comparative studies in thalassemia patients treated with deferoxamine or a deferoxamine/deferiprone combination. Identification of effective chelation therapy protocols
    • Kolnagou A, Economides Ch, Eracleous E, Kontoghiorghes GJ. Long term comparative studies in thalassemia patients treated with deferoxamine or a deferoxamine/deferiprone combination. Identification of effective chelation therapy protocols. Hemoglobin. 2008;32(1-2):41-47.
    • (2008) Hemoglobin , vol.32 , Issue.1-2 , pp. 41-47
    • Kolnagou, A.1    Ch, E.2    Eracleous, E.3    Kontoghiorghes, G.J.4
  • 13
    • 0037125595 scopus 로고    scopus 로고
    • Comparison of effects of oral deferiprone and subcutaneous desferrioxamine on myocardial iron concentrations and ventricular function in b-thalassaemia
    • Anderson LJ, Wonke B, Prescott E, Holden S, Walker JM, Pennell DJ. Comparison of effects of oral deferiprone and subcutaneous desferrioxamine on myocardial iron concentrations and ventricular function in b-thalassaemia. Lancet. 2002;360(9332):516-520.
    • (2002) Lancet , vol.360 , Issue.9332 , pp. 516-520
    • Anderson, L.J.1    Wonke, B.2    Prescott, E.3    Holden, S.4    Walker, J.M.5    Pennell, D.J.6
  • 14
    • 27644539382 scopus 로고    scopus 로고
    • Intracellular labile iron pools as direct targets of iron chelators: A fluorescence study of chelator action in living cells
    • Glickstein H, El RB, Shvartsman M, Cabantchik ZI. Intracellular labile iron pools as direct targets of iron chelators: a fluorescence study of chelator action in living cells. Blood. 2005;106(9):3242-3250.
    • (2005) Blood , vol.106 , Issue.9 , pp. 3242-3250
    • Glickstein, H.1    El, R.B.2    Shvartsman, M.3    Cabantchik, Z.I.4
  • 15
    • 0034928342 scopus 로고    scopus 로고
    • "Iron shuttle" hypothesis in chelation therapy: Effects of combined deferoxamine and deferiprone treatment in hyper transfused rats with labeled iron stores and in iron-loaded rat heart cells in culture
    • Link G, Konijn AM, Breuer W, Cabantchik ZI, Hershko C. Exploring the "iron shuttle" hypothesis in chelation therapy: effects of combined deferoxamine and deferiprone treatment in hypertransfused rats with labeled iron stores and in iron-loaded rat heart cells in culture. J Lab Clin Med. 2001;138(2):130-138.
    • (2001) J Lab Clin Med , vol.138 , Issue.2 , pp. 130-138
    • Link, G.1    Konijn, A.M.2    Breuer, W.3    Cabantchik, Z.I.4    The Exploring, H.C.5
  • 16
    • 0842287261 scopus 로고    scopus 로고
    • Magnetic resonance screening of iron status in transfusion dependent b-thalassaemia patients
    • Ooi GC, Khong PL, Chan GC, et al. Magnetic resonance screening of iron status in transfusiondependent b-thalassaemia patients. Br J Haematol. 2004;124(3):385-390.
    • (2004) Br J Haematol , vol.124 , Issue.3 , pp. 385-390
    • Ooi, G.C.1    Khong, P.L.2    Chan, G.C.3
  • 17
    • 1642313571 scopus 로고    scopus 로고
    • Evaluation of iron overload
    • Jensen PD. Evaluation of iron overload. Br J Haematol. 2004;124(6):697-711.
    • (2004) Br J Haematol , vol.124 , Issue.6 , pp. 697-711
    • Jensen, P.D.1
  • 18
    • 0242584372 scopus 로고    scopus 로고
    • Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients
    • Mourad FH, Hoffbrand AV, Sheikh-Taha M, et al. Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients. Br J Haematol. 2003;121(1):187-189.
    • (2003) Br J Haematol , vol.121 , Issue.1 , pp. 187-189
    • Mourad, F.H.1    Hoffbrand, A.V.2    Sheikh-Taha, M.3
  • 19
    • 33646677440 scopus 로고    scopus 로고
    • Combined therapy with desferrioxamine and deferiprone in b thalassemia major patients with transfusional iron overload
    • Daar S, Pathare AV. Combined therapy with desferrioxamine and deferiprone in b thalassemia major patients with transfusional iron overload. Ann Hematol. 2006;85(5):315-319.
    • (2006) Ann Hematol , vol.85 , Issue.5 , pp. 315-319
    • Daar, S.1    Pathare, A.V.2
  • 20
    • 30344471110 scopus 로고    scopus 로고
    • Iron chelation treatment with combined therapy with deferiprone and deferioxamine: A 12-month trial
    • Kattamis A, Ladis V, Berdousi H, et al. Iron chelation treatment with combined therapy with deferiprone and deferioxamine: a 12-month trial. Blood Cells Mol Dis. 2006;36(1):21-25.
    • (2006) Blood Cells Mol Dis , vol.36 , Issue.1 , pp. 21-25
    • Kattamis, A.1    Ladis, V.2    Berdousi, H.3
  • 21
    • 33748783066 scopus 로고    scopus 로고
    • A prospective randomized controlled trial on the safety and efficacy of alternating deferoxamine and deferiprone in the treatment of iron overload in patients with thalassemia
    • Galanello R, Kattamis A, Piga A, et al. A prospective randomized controlled trial on the safety and efficacy of alternating deferoxamine and deferiprone in the treatment of iron overload in patients with thalassemia. Haematologica. 2006;91(9):1241-1243.
    • (2006) Haematologica , vol.91 , Issue.9 , pp. 1241-1243
    • Galanello, R.1    Kattamis, A.2    Piga, A.3
  • 22
    • 33845900683 scopus 로고    scopus 로고
    • Four-year evaluation of myocardial and liver iron assessed prospectively with serial MRI scans in young patients with b-thalassaemia major: Comparison between different chelation regimens
    • Christoforidis A, Haritandi A, Tsatra I, Tsitourides I, Karyda S, Athanassiou-Metaxa M. Four-year evaluation of myocardial and liver iron assessed prospectively with serial MRI scans in young patients with b-thalassaemia major: comparison between different chelation regimens. Eur J Haematol. 2007;78(1):52-57.
    • (2007) Eur J Haematol , vol.78 , Issue.1 , pp. 52-57
    • Christoforidis, A.1    Haritandi, A.2    Tsatra, I.3    Tsitourides, I.4    Karyda, S.5    Athanassiou-Metaxa, M.6
  • 23
    • 34247103036 scopus 로고    scopus 로고
    • A randomized, placebo controlled, double-blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassemia major using cardiovascular magnetic resonance
    • Tanner MA, Galanello R, Dessi C, et al. A randomized, placebo controlled, double-blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassemia major using cardiovascular magnetic resonance. Circulation. 2007;115(14):1876-1884.
    • (2007) Circulation , vol.115 , Issue.14 , pp. 1876-1884
    • Tanner, M.A.1    Galanello, R.2    Dessi, C.3
  • 24
    • 38349075317 scopus 로고    scopus 로고
    • Comparison of effects of different long-term iron-chelation regimens on myocardial and hepatic iron concentrations assessed with T2* magnetic resonance imaging in patients with b-thalassemia major
    • Perifanis V, Christoforidis A, Vlachaki E, Tsatra I, Spanos G, Athanassiou-Metaxa M. Comparison of effects of different long-term iron-chelation regimens on myocardial and hepatic iron concentrations assessed with T2* magnetic resonance imaging in patients with b-thalassemia major. Int J Hematol. 2007;86(5):385-389.
    • (2007) Int J Hematol , vol.86 , Issue.5 , pp. 385-389
    • Perifanis, V.1    Christoforidis, A.2    Vlachaki, E.3    Tsatra, I.4    Spanos, G.5    Athanassiou-Metaxa, M.6
  • 25
    • 44449104925 scopus 로고    scopus 로고
    • Iron chelation in thalassemia: Combined or monotherapy? the Egyptian experience
    • El-Beshlawy A, Manz C, Naja M, et al. Iron chelation in thalassemia: combined or monotherapy? The Egyptian experience. Ann Hematol. 2008;87(7):545-550.
    • (2008) Ann Hematol , vol.87 , Issue.7 , pp. 545-550
    • El-Beshlawy, A.1    Manz, C.2    Naja, M.3
  • 26
    • 39349089027 scopus 로고    scopus 로고
    • Effects of combined deferiprone and deferoxamine chelation therapy on iron load indices in b-thalassemia
    • Tsironi M, Assimakopoulos G, Polonofi K, Rigaki K, Aessopos A. Effects of combined deferiprone and deferoxamine chelation therapy on iron load indices in b-thalassemia. Hemoglobin. 2008;32(1-2):29-34.
    • (2008) Hemoglobin , vol.32 , Issue.1-2 , pp. 29-34
    • Tsironi, M.1    Assimakopoulos, G.2    Polonofi, K.3    Rigaki, K.4    Aessopos, A.5
  • 28
    • 0035254193 scopus 로고    scopus 로고
    • Deferoxamine chelatable iron, a component of serum non-transfusion-bound iron, used for assessing chelation therapy
    • Breuer W, Empers MJJ, Pootrakul P, et al. Deferoxamine chelatable iron, a component of serum non-transfusion-bound iron, used for assessing chelation therapy. Blood. 2001;97(3):792-798.
    • (2001) Blood , vol.97 , Issue.3 , pp. 792-798
    • Breuer, W.1    Empers, M.J.J.2    Pootrakul, P.3
  • 30
    • 0026668939 scopus 로고
    • Long-term assessment of efficacy and safety of deferiprone, an oral iron chelator, in transfusion dependent thalassaemia: Indian trial
    • Agarwal MB, Gupte SS, Viswanathan C, et al. Long-term assessment of efficacy and safety of deferiprone, an oral iron chelator, in transfusion dependent thalassaemia: Indian trial. Br J Haematol. 1992; 82(2):460-466.
    • (1992) Br J Haematol , vol.82 , Issue.2 , pp. 460-466
    • Agarwal, M.B.1    Gupte, S.S.2    Viswanathan, C.3
  • 31
    • 36448937511 scopus 로고    scopus 로고
    • Deferiprone in the treatment of transfusion-dependent thalassemia: A review and perspective
    • Galanello R. Deferiprone in the treatment of transfusion-dependent thalassemia: a review and perspective. Ther Clin Risk Manag. 2007;3(5):795-805.
    • (2007) Ther Clin Risk Manag , vol.3 , Issue.5 , pp. 795-805
    • Galanello, R.1
  • 32
    • 39349096186 scopus 로고    scopus 로고
    • Long term comparative studies in thalassemia patients treated with deferoxamine or a deferoxamine/deferiprone combination. Identification of effective chelation therapy protocols
    • Kolnagou A, Economides Ch, Eracleous E, Kontoghiorghes GJ. Long term comparative studies in thalassemia patients treated with deferoxamine or a deferoxamine/deferiprone combination. Identification of effective chelation therapy protocols. Hemoglobin. 2008;32(1-2):41-47.
    • (2008) Hemoglobin , vol.32 , Issue.1-2 , pp. 41-47
    • Kolnagou, A.1    Ch, E.2    Eracleous, E.3    Kontoghiorghes, G.J.4
  • 33
    • 34547135935 scopus 로고    scopus 로고
    • Bone marrow changes in b-thalassemia major: Quantitative MR imaging findings and correlation with iron stores
    • Drakonaki EE, Maris TG, Papadakis A, Karantanas AH. Bone marrow changes in b-thalassemia major: quantitative MR imaging findings and correlation with iron stores. Eur Radiol. 2007;17(7):2079-2087.
    • (2007) Eur Radiol , vol.17 , Issue.7 , pp. 2079-2087
    • Drakonaki, E.E.1    Maris, T.G.2    Papadakis, A.3    Karantanas, A.H.4
  • 35
    • 0025230594 scopus 로고
    • Non-invasive quantitation of liver iron-overload by magnetic resonance imaging
    • Kaltwasser JP, Gottschalk R, Schalk KP, et al. Non-invasive quantitation of liver iron-overload by magnetic resonance imaging. Br J Haematol. 1990;74(3):360-363.
    • (1990) Br J Haematol , vol.74 , Issue.3 , pp. 360-363
    • Kaltwasser, J.P.1    Gottschalk, R.2    Schalk, K.P.3
  • 36
    • 0029363067 scopus 로고
    • Iron overload in thalassemia: Comparative analysis of magnetic resonance imaging, serum ferritin and iron content of the liver
    • Mazza P, Giua R, De Marco S, et al. Iron overload in thalassemia: comparative analysis of magnetic resonance imaging, serum ferritin and iron content of the liver. Haematologica. 1995;80(5):398-404.
    • (1995) Haematologica , vol.80 , Issue.5 , pp. 398-404
    • Mazza, P.1    Giua, R.2    De Marco, S.3
  • 37
    • 65249141150 scopus 로고    scopus 로고
    • Assessment of iron distribution between liver, spleen, pancreas, bone marrow, and myocardium by means of R2 relaxometry with MRI in patients with b-thalassemia major
    • Papakonstantinou O, Alexopoulou E, Economopoulos N, et al. Assessment of iron distribution between liver, spleen, pancreas, bone marrow, and myocardium by means of R2 relaxometry with MRI in patients with b-thalassemia major. J Magn Reson Imaging. 2009;29(4):853-859.
    • (2009) J Magn Reson Imaging , vol.29 , Issue.4 , pp. 853-859
    • Papakonstantinou, O.1    Alexopoulou, E.2    Economopoulos, N.3


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