Reduction of the multiple organ injury and dysfunction caused by endotoxemia in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton

Journal of Leukocyte Biology

Volumn 76, Issue 5, 2004, Pages 961-970

  Collin, Marika ^a   Rossi, Antonietta ^b   Cuzzocrea, Salvatore ^c   Patel, Nimesh S A ^a   Di Paola, Rosanna ^c   Hadley, Julia ^a   Collino, Massimo ^a   Sautebin, Lidia ^b   Thiemermann, Christoph ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF MESSINA   (Italy)

Author keywords

2 integrins; CD11a CD18; CD11b CD18; Leukotrienes; Shock

Indexed keywords

ALANINE AMINOTRANSFERASE; AMYLASE; ARACHIDONATE 5 LIPOXYGENASE; ASPARTATE AMINOTRANSFERASE; BETA2 INTEGRIN; CD11 ANTIGEN; CD18 ANTIGEN; DIMETHYL SULFOXIDE; ENDOTOXIN; GAMMA GLUTAMYLTRANSFERASE; LEUKOTRIENE; LIPOPOLYSACCHARIDE; LIPOXYGENASE INHIBITOR; TRIACYLGLYCEROL LIPASE; ZILEUTON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENDOTOXEMIA; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE DISRUPTION; GENE TARGETING; KNOCKOUT MOUSE; LIVER INJURY; LIVER METABOLISM; MALE; MULTIPLE ORGAN FAILURE; NEUTROPHIL; NONHUMAN; PANCREAS INJURY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIGENS, CD11; ANTIGENS, CD18; ARACHIDONATE 5-LIPOXYGENASE; CHEMOTAXIS, LEUKOCYTE; DISEASE MODELS, ANIMAL; ENDOTOXEMIA; ENZYMES; GENE TARGETING; HYDROXYUREA; LEUKOCYTES; LIPOPOLYSACCHARIDES; LIPOXYGENASE INHIBITORS; LIVER; LUNG; MALE; MICE; MICE, KNOCKOUT; MULTIPLE ORGAN FAILURE; PANCREAS; RATS; RATS, WISTAR; VISCERA;

ANIMALIA; ESCHERICHIA COLI;

EID: 7644235203     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0604338     Document Type: Article

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