Galantamine blocks cloned Kv2.1, but not Kv1.5 potassium channels

Molecular Brain Research

Volumn 131, Issue 1-2, 2004, Pages 136-140

  Zhang, Hai Xia ^a   Zhang, Wei ^a   Jin, Hong Wei ^a   Wang, Xiao Liang ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Acetylcholinesterase inhibitors; Alzheimer's disease; Galanthamine; Kv1.5 potassium channel; Kv2.1 potassium channel; Patch clamp techniques

Indexed keywords

GALANTAMINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KV1.5;

ARTICLE; CONCENTRATION RESPONSE; DRUG SENSITIVITY; ELECTRIC POTENTIAL; EMBRYO; HUMAN; HUMAN CELL; PATCH CLAMP; POTASSIUM CHANNEL KV2.1; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECORDING;

CELL LINE; CHOLINESTERASE INHIBITORS; CLONING, MOLECULAR; GALANTAMINE; HUMANS; KIDNEY; KV1.5 POTASSIUM CHANNEL; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; POTASSIUM; POTASSIUM CHANNELS, VOLTAGE-GATED; SHAB POTASSIUM CHANNELS;

EID: 7644228119     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbrainres.2004.08.010     Document Type: Article

References (20)

1. K.G. Chandy, C.B. Williams, R.H. Spencer, B.A. Aguilar, S. Ghanshani, B.L. Tempel, and G.A. Gutman A family of three mouse potassium channel genes with intronless coding regions Science 247 1990 973 975
2. L.V. Colom, M.E. Diaz, D.R. Beers, A. Neely, W.J. Xie, and S.H. Appel Role of potassium channels in amyloid-induced cell death J. Neurochem. 70 1998 1925 1934
3. + channel, Kv2.1, is apposed to astrocytic processes and is associated with inhibitory postsynaptic membranes in hippocampal and cortical principal neurons and inhibitory interneurons Neuroscience 84 1998 37 48
4. + current in cultured adult human atrial myocytes Circ. Res. 80 1997 572 579
5. E. Giacobini Cholinesterase inhibitors stabilize Alzheimer's disease Ann. N.Y. Acad. Sci. 920 2000 321 327
6. + channels of the Shab subfamily J. Neurosci. 13 1993 1569 1576
7. H.W. Jin, W. Zhang, and X.L. Wang Effects of chronic exposure to beta-amyloid-peptide25-35 on the mRNA expressions of voltage-gated outward potassium channel subunits in cultured rat hippocampal neurons Acta Pharm. Sin. 37 2002 598 602
8. D. Kraliz, and S. Singh Selective blockade of the delayed rectifier potassium current by tacrine in Drosophila J. Neurobiol. 32 1997 1 10
9. A. Maelicke, and E.X. Albuquerque Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease Eur. J. Pharmacol. 393 2000 165 170
10. + channel polypeptides in rat hippocampal neurons developing in situ and in vitro J. Neurosci. 15 5 Pt 2 1995 3840 3851
11. + channel alters voltage-dependent activation Mol. Pharmacol. 52 1997 821 828
12. + current in rat hippocampal neurons J. Neurosci. 19 1999 1728 1735
13. A. Nordberg, and A.L. Svensson Cholinesterase inhibitors in the treatment of Alzheimer's disease: a comparison of tolerability and pharmacology Drug Safety 19 1998 465 480
14. S. Pal, K.A. Hartnett, J.M. Nerbonne, E.S. Levitan, and E. Aizenman Mediation of neuronal apoptosis by Kv2.1-encoded potassium channels J. Neurosci. 23 12 2003 4798 4802
15. Y.P. Pan, X.H. Xu, and X.L. Wang Galantamine blocks delayed rectifier, but not transient outward potassium current in rat dissociated hippocampal pyramidal neurons Neurosci. Lett. 336 2003 37 40
16. M.A. Rogawski Tetrahydroaminoacridine blocks voltage dependent ion channels in hippocampal neurons Eur. J. Pharmacol. 142 1987 169 172
17. J.F. Storm Potassium currents in hippocampal pyramidal cells Prog. Brain Res. 83 1990 161 187
18. + current densities and Kv1.5 expression are reduced in chronic human atrial fibrillation Circ. Res. 80 1997 772 781
19. S.P. Yu, Z.S. Farhangrazi, H.S. Ying, C.H. Yeh, and D.W. Choi Enhancement of outward potassium current may participate in beta-amyloid peptide-induced cortical neuronal death Neurobiol. Dis. 5 1998 81 88
20. C.B. Zhong, W. Zhang, and X.L. Wang Effects of donepezil on the delayed rectifier-like potassium current in pyramidal neurons of rat hippocampus and neocortex Acta Pharm. Sin. 37 6 2002 415 418