Allele-specific overexpression in astrocytes of an Alzheimer's disease associated alpha-1-antichymotrypsin promoter polymorphism

Molecular Brain Research

Volumn 131, Issue 1-2, 2004, Pages 88-92

  Ritchie, Alistair ^a   Morgan, Kevin ^a   Kalsheker, Noor ^a  

^a Sch Clin Med Sci Gerontology   (United Kingdom)

Author keywords

Allele specific overexpression; Alpha 1 antichymotrypsin; Astrocytes

Indexed keywords

ALPHA 1 ANTICHYMOTRYPSIN; AMYLOID BETA PROTEIN; ONCOSTATIN M;

ALLELE; ALZHEIMER DISEASE; ARTICLE; ASTROCYTE; DNA POLYMORPHISM; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; NEUROTOXICITY; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION INITIATION;

ALLELES; ALPHA 1-ANTICHYMOTRYPSIN; ALZHEIMER DISEASE; ASTROCYTES; BASE SEQUENCE; CELL LINE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION; HUMANS; MOLECULAR SEQUENCE DATA; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS);

EID: 7644222028     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbrainres.2004.08.012     Document Type: Article

References (20)

1. C.R. Abraham, D.J. Selkoe, and H. Potter Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease Cell 52 1988 487 501
2. J.J. Bao, R.N. Sifers, V.J. Kidd, F.D. Ledley, and S.L. Woo Molecular evolution of serpins: homologous structure of the human alpha 1-antichymotrypsin and alpha 1-antitrypsin genes Biochemistry 26 1987 7755 7759
3. G.D. Billingsley, M.A. Walter, G.L. Hammond, and D.W. Cox Physical mapping of four serpin genes: alpha 1-antitrypsin, alpha 1-antichymotrypsin, corticosteroid-binding globulin, and protein C inhibitor, within a 280-kb region on chromosome I4q32.1 Am. J. Hum. Genet. 52 1993 343 353
4. F. Burnett Aetiology of Alzheimer's disease C. Kelly Alzheimer's Disease Handbook 2000 Merit Publishing International Basingstoke 51 66
5. R.W. Carrell, and D.A. Lomas Conformational disease Lancet 350 1997 134 138
6. S. Eriksson, S. Janciauskiene, and L. Lannfelt Alpha 1-antichymotrypsin regulates Alzheimer beta-amyloid peptide fibril formation Proc. Natl. Acad. Sci. U. S. A. 92 1995 2313 2317
7. S.I. Gracon, and M. Emmerling Current perspectives, future directions D. Dawburn Neurobiology of Alzheimer's Disease 2001 Oxford University Press Oxford 369 388
8. N.A. Kalsheker Alpha 1-antichymotrypsin Int. J. Biochem. Cell Biol. 28 1996 961 964
9. T. Kordula, R.E. Rydel, E.F. Brigham, F. Horn, P.C. Heinrich, and J. Travis Oncostatin M and the interleukin-6 and soluble interleukin-6 receptor complex regulate alpha1-antichymotrypsin expression in human cortical astrocytes J. Biol. Chem. 273 1998 4112 4118
10. F. Licastro, M. Chiappelli, L.M.E. Grimaldi, K. Morgan, N. Kalsheker, E. Calabrese, A. Ritchie, E. Porcellini, G. Salani, M. Franceschi, N. Canal, A new promoter polymorphism in the alpha-1-antichymotrypsin gene is a disease modifier of Alzheimer's disease, Neurobiology of Aging (In Press).
11. P.L. McGeer, and E.G. McGeer The possible role of complement activation in Alzheimer disease Trends Mol. Med. 8 2002 519 523
12. K. Morgan, F. Licastro, L. Tilley, A. Ritchie, L. Morgan, S. Pedrini, and N. Kalsheker Polymorphism in the alpha(1)-antichymotrypsin (ACT) gene promoter: effect on expression in transfected glial and liver cell lines and plasma ACT concentrations Hum. Genet. 109 2001 303 310
13. L. Mucke, G.Q. Yu, L. McConlogue, E.M. Rockenstein, C.R. Abraham, and E. Masliah Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice Am. J. Pathol. 157 2000 2003 2010
14. L.N. Nilsson, K.R. Bales, G. DiCarlo, M.N. Gordon, D. Morgan, S.M. Paul, and H. Potter Alpha-1-antichymotrypsin promotes beta-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer's disease J. Neurosci. 21 2001 1444 1451
15. L.N. Nilsson, S. Das, and H. Potter Effect of cytokines, dexamethasone and the A/T-signal peptide polymorphism on the expression of alpha(1)-antichymotrypsin in astrocytes: significance for Alzheimer's disease Neurochem. Int. 39 2001 361 370
16. L.N.G. Nilsson, G.W. Arendash, R.E. Leighty, D.A. Costa, M.A. Low, M.F. Garcia, J.R. Cracciolo, A. Rojiani, X. Wu, K.R. Bales, S.M. Paul, and H. Potter Cognitive impairment in PDAPP mice depends on ApoE and ACT-catalyzed amyloid formation Neurobiol. Aging 25 2004 1153 1167
17. R.G. Roeder The role of general initiation factors in transcription by RNA polymerase II Trends Biochem. Sci. 21 1996 327 335
18. A. Singleton, A. Myers, and J. Hardy The law of mass action applied to neurodegenerative disease: a hypothesis concerning the aetiology and pathogenesis of complex diseases Hum. Mol. Genet. 2004 ddh093
19. J. Travis, and G.S. Salvesen Human plasma proteinase inhibitors Annu. Rev. Biochem. 52 1983 655 709
20. N.A. Woychik, and M. Hampsey The RNA polymerase II machinery: structure illuminates function Cell 108 2002 453 463