Mitogen-activated protein kinases and tumor necrosis factor alpha responses of macrophages infected with Orientia tsutsugamushi

World Journal of Microbiology and Biotechnology

Volumn 25, Issue 12, 2009, Pages 2157-2164

  Yun, Ji Hyun ^a,b   Koo, Jung Eun ^a   Koh, Young Sang ^a  

^a Jeju National University School of Medicine   (South Korea)

^b EM Research Institute   (South Korea)

Author keywords

Mitogen activated protein kinase; Nuclear factor kappa B; Orientia tsutsugamushi; Tumor necrosis factor alpha

Indexed keywords

CAUSATIVE AGENTS; CELLULAR ATTACHMENTS; CYCLOHEXIMIDES; CYTOCHALASIN D; DE NOVO SYNTHESIS; EUKARYOTIC PROTEIN SYNTHESIS; HOST CELL PROTEIN; HOST CELLS; INFLAMMATORY RESPONSE; INTRACELLULAR BACTERIA; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEAR FACTOR KAPPAB; TRANSCRIPTIONAL RESPONSE; TUMOR NECROSIS FACTOR ALPHA;

ENZYME ACTIVITY; GLYCOPROTEINS; MACROPHAGES; TUMORS;

PROTEINS;

BACTERIA (MICROORGANISMS); EUKARYOTA; ORIENTIA; ORIENTIA TSUTSUGAMUSHI;

EID: 76349114444     PISSN: 09593993     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11274-009-0120-5     Document Type: Article

References (27)

1. Akira S, Takeda K (2004) Toll-like receptor signalling. Nat Rev Immunol 4: 499-511.
2. Allen AC, Spitz S (1945) A comparative study of the pathology of scrub typhus (tsutsugamushi disease) and other rickettsial disease. Am J Pathol 21: 603-681.
3. Beutler B, Cerami A (1986) Cachectin and tumor necrosis factor as two sides of the same biological coin. Nature 320: 584-588.
4. Burnett JW (1980) Rickettsioses: a review for the dermatologist. J Am Acad Dermatol 2: 359-373.
5. Chi WC, Huang JJ, Sung JM, Lan R, Ko WC, Chen FF (1997) Scrub typhus associated with multiorgan failure: a case report. Scand J Infect Dis 29: 634-635.
6. Cho NH, Seong SY, Huh MS, Han TH, Koh YS, Choi MS, Kim IS (2000) Expression of chemokine genes in murine macrophage infected with Orientia tsutsugamushi. Infect Immun 68: 594-602.
7. Dumitru CD, Ceci JD, Tsatsanis C, Kontoyiannis D, Stamatakis K, Lin JH, Patriotis C, Jenkins NA, Copeland NG, Kollias G, Tsichlis PN (2000) TNF-α induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell 103: 1071-1083.
8. Falvo JV, Uglialoro AM, Brinkman BMN, Merika M, Parekh BS, Tsai EY, King HC, Morielli AD, Peralta EG, Maniatis T, Thanos D, Goldfeld AE (2000) Stimulus-specific assembly of enhancer complexes on the tumor necrosis factor alpha gene promoter. Mol Cell Biol 20: 2239-2247.
9. Geng P, Jerrells TR (1994) The role of tumor necrosis factor in host defense against scrub typhus rickettsiae. I. Inhibition of growth of Rickettsia tsutsugamushi, Karp strain, in cultured murine embryonic cells and macrophages by recombinant tumor necrosis factor-alpha. Microbiol Immunol 38: 703-711.
10. Han J, Brown T, Beutler B (1990) Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level. J Exp Med 171: 465-475.
11. Iwasaki H, Tskada N, Nakamura T, Ueda T (1997) Increased levels of macrophage colony-stimulating factor, gamma interferon, and tumor necrosis factor alpha in sera of patients with infection. J Clin Microbiol 335: 3320-3322.
12. Kim MK, Kang JS (2001) Orientia tsutsugamushi suppresses the production of inflammatory cytokines induced by its own heat-stable component in murine macrophages. Microb Pathog 31: 145-150.
13. Koh YS (2001) Expression of chemokine and tumor necrosis factor alpha genes in murine peritoneal macrophages infected with Orientia tsutsugamushi. J Microbiol 39: 186-194.
14. Koh YS, Yun JH, Seong SY, Choi MS, Kim IS (2004) Chemokine and cytokine production during Orientia tsutsugamushi infection in mice. Microb Pathog 36: 51-57.
15. Kontoyiannis D, Pasparakis M, Pizarro TT, Cominelli F, Kollias G (1999) Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 10: 387-398.
16. Kotlyarov A, Neininger A, Shubtert C, Eckert R, Birchmeier C, Volk HD, Gaestel M (1999) MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis. Nat Cell Biol 1: 94-97.
17. Kracht M, Saklatvala J (2002) Transcriptional and post-transcriptional control of gene expression in inflammation. Cytokine 20: 91-106.
18. Kruys V, Kemmer K, Shakov A, Jongeneel V, Beutler B (1992) Constitutive activity of the TNF promoter is canceled by the 3′-UTR in nonmacrophage cell lines: a trans-dominant factor overcomes this suppressive effect. Proc Natl Acad Sci USA 89: 673-677.
19. 2 activation is via the MKP-1 down-regulation and ERK activation. Cell Signal 12: 457-461.
20. Medzhitov R, Preston-Hurlburt P, Janeway CA Jr (1997) A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388: 394-397.
21. Ng FK, Oaks SC Jr, Lee M, Groves MG, Lewis GE Jr (1985) A scanning and transmission electron microscopic examination of Rickettsia tsutsugamushi-infected human endothelial, MRC-5, and L-929 cells. Jpn J Med Sci Biol 38: 125-139.
22. Rikihisa Y, Ito S (1979) Intracellular localization of Rickettsia tsutsugamushi in polymorphonuclear leukocytes. J Exp Med 150: 703-708.
23. Rikihisa Y, Ito S (1982) Entry of Rickettsia tsutsugamushi into polymorphonuclear leukocytes. Infect Immun 38: 343-350.
24. Roux PP, Blenis J (2004) ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev 68: 320-344.
25. Vaddi K, Keller M, Newton RC (1997) The chemokine FactsBook. Academic Press, New York.
26. Yun JH, Koh YS, Lee KH, Hyun JW, Choi YJ, Jang WJ, Park KH, Cho NH, Seong SY, Choi MS, Kim IS (2005) Chemokine and cytokine production in susceptible C3H/HeN mice and resistance BALB/c mice during Orientia tsutsugamushi infection. Microbiol Immunol 49: 551-557.
27. Yun JH, Koo JE, Koh YS (2009) Mitogen-activated protein kinases are involved in tumor necrosis factor alpha production in macrophages infected with Orientia tsutsugamushi. Microbiol Immunol 53: 349-355.