Verbena officinalis essential oil and its component citral as apoptotic-inducing agent in chronic lymphocytic leukemia

International Journal of Immunopathology and Pharmacology

Volumn 22, Issue 4, 2009, Pages 1097-1104

  De Martino, L ^a   D'Arena, G ^b   Minervini, M M ^b   Deaglio, S ^c   Fusco, B M ^d   Cascavilla, N ^b   De Feo, Vincenzo ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

^d IRCCS SAN RAFFAELE PISANA   (Italy)

Author keywords

Apoptosis; Chronic lymphocytic leukemia; Citral; Verbena officinalis

Indexed keywords

CITRAL; ESSENTIAL OIL; PROCASPASE 3; PROTEIN P53; VERBENA OFFICINALIS EXTRACT;

ADULT; AGED; APOPTOSIS; ARTICLE; BLOOD DONOR; CHROMOSOME 17P; CHROMOSOME ABERRATION; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; FEMALE; GENE MUTATION; HUMAN; INCUBATION TIME; KARYOTYPE; MALE; MEDICINAL PLANT; PRIORITY JOURNAL;

EID: 76349083830     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463200902200426     Document Type: Article

References (20)

1. Hursting SD, Fisher SM, Wargovich MJ, Digiovanni J. Nutritional modulation of the carcinogenesis process. In: Nutritional Oncology, Heber D, Blackburn G (eds.). Academic Press: San Diego CA; 1999. p. 91-104.
2. Wattenberg LW. Inhibition of carcinogenesis by minor dietary constituents. Cancer Res 1992; 52:2085-91.
3. Mo H, Elson CE. Apoptosis and cell-cycle arrest in human and murine tumor cells are initiated by isoprenoids. J Nutr 1999; 129:804-13.
4. Tatman D, Mo H. Volatile isoprenoid constituents of fruits, vegetables and herbs cumulatively suppress the proliferation of murine B16 melanoma and human HL-60 leukemia cells. Cancer Lett 2002; 175:129-39.
5. Sau-Wan L, Man-Shan Y, Wai-Hung Y, Chang R C-C. Novel neuroprotective effects of the aqueous extracts from Verbena officinalis Linn. Neuropharmacology 2006; 50:641-50.
6. De Martino L, Iorio M, Coppola G, Campana A, Savastano C, Fusco BM, De Feo V. Verbena officinalis essential oil and citral as apoptotic inductors in leukocytes of healthy subjects and chronic myeloid leukemic patients. Pharmacologyonline 2008; 2:170-5.
7. Reed JC, Kitada S. Apoptosis dysregulation in chronic lymphocytic leukemia. 2001. In: Chronic lymphoid leukemias. Ed. Cheson B. Marcel Dekker, Inc., NY, USA. p. 111-26.
8. Chiorazzi N, Rai KR, Ferrarini M. Chronic lymphocytic leukemia. N Engl J Med 2005; 352:804-15.
9. Dighiero G, Hamblin TJ. Chronic lymphocytic leukemia. Lancet 2008; 371:1017-29.
10. Europeian Pharmacopoeia, 2004, (5th Edition): Council of Europe, Strasbourg Cedex, France 2.8.12, p. 217-18.
11. Jennings W, Shibamoto T. 1980. Qualitative Analysis of Flavour and Fragrance Volatiles by Glass Capillary Gas Chromatography. Academic Press: New York.
12. Davies NW. Gas chromatographic retention indices of monoterpenes and sesquiterpenes on methyl silicone and Carbowax 2OM phases. J Chromatogr 1990; 503:1-24.
13. Adams RP. 2001. Identification of Essential Oil Components by Gas Chromatography/Mass Spectroscopy. Allured Publishing: Carol Stream, IL.
14. Dudai N, Weinstein Y, Krup M, Rabinski T, Ofir R. Citral is a new inducer of caspase-3 in tumor cell lines. Planta Med 2005; 71:484-8.
15. Döhner H, Stilgenbauer S, Benner A, Leupolt E, Kröber A, Bullinger L, Döhner K, Bentz M, Lichter P. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000; 343:1910-16.
16. Seiler T, Döhner H, Stilgenbauer S. Risk stratification in chronic lymphocytic leukemia. Semin Oncol 2006; 33:186-94.
17. Sturm I, Bosanquest AG, Hermann S, Guner D, et al. Mutation of p53 and consecutive selective drug ? resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy. Cell Death Differ 2003; 10:477-84.
18. Stilgenbauer S, Kröber A, Busch R, Eichorst B, et al. 17p deletion predicts for shorter overall survival after fludarbine-based first line therapy in chronic lymphocytic leukemia: first analysis of the CLL trial of the GCLLSG. Onkologie 2005; 28(S):29-30.
19. Carnesecchi S, Schneider Y, Ceraline J, Duranton B, Gosse F, Seiler N, Raul F. Geraniol, a component of plant essential oils inhibits growth and polyamine biosynthesis in human colon cancer cells. J Pharmacol Exp Ther 2001; 298:197-200.
20. Bardon S, Picard K, Martel P. Monoterpenes inhibit cell growth, cell cycle progression and cyclin D1 gene expression in human breast cancer cell lines. Nutr Cancer 1998; 32:1-7.