DKK1 correlates with response and predicts rapid relapse after autologous stem cell transplantation in Multiple Myeloma

European Journal of Haematology

Volumn 84, Issue 3, 2010, Pages 276-277

  Lemaire, Olivia ^a   Attal, Michel ^a   Bourin, Philippe ^a   Laroche, Michel ^a  

^a CHU PURPAN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; DEXAMETHASONE; DICKKOPF 1 PROTEIN; DOXORUBICIN; MELPHALAN; THALIDOMIDE; VINCRISTINE;

ADULT; AUTOLOGOUS STEM CELL TRANSPLANTATION; CANCER COMBINATION CHEMOTHERAPY; CANCER PATIENT; CANCER STAGING; CLINICAL ARTICLE; FEMALE; HUMAN; LETTER; MALE; MULTIPLE MYELOMA; PRIORITY JOURNAL; PROTEIN ANALYSIS;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BORONIC ACIDS; COMBINED MODALITY THERAPY; DEXAMETHASONE; DOXORUBICIN; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MELPHALAN; MIDDLE AGED; MULTIPLE MYELOMA; MYELOMA PROTEINS; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PROGNOSIS; PYRAZINES; RECURRENCE; THALIDOMIDE; TRANSPLANTATION, AUTOLOGOUS; TUMOR MARKERS, BIOLOGICAL; VINCRISTINE;

EID: 76249127182     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/j.1600-0609.2009.01372.x     Document Type: Letter

References (6)

1. Kaiser M, Mieth M, Liebisch P, et al. Serum concentrations of DKK1 correlate with the extent of bone disease in patients with Multiple Myeloma. Eur J Haematol 2008 80 : 490 493.
2. Heider U, Kaiser M, Mieth M, Lamottke B, Rademacher J, Jakob C, Braendle E, Stover D, Sezer O. Serulm concentrations of DKK1 decrease in patients with Multiple Myeloma responding to anti-myeloma treatment. Eur J Haematol 2008 82 : 31 8.
3. Fedi P, Bafico A, Nieto Soria A, Burgess WH, Miki T, Bottaro DP, Kraus MH, Aaronson SA. Isolation and biochemical characterization of the human DKK-1 homologue, a novel inhibitor of mammalian Wnt signaling. J Biol Chem 1999 274 : 19465 19472.
4. Tian E, Zhan F, Walker R, Rasmussen E, Ma Y, Barlogie B, Shaugnessy JD. The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in Multiple Myeloma. N Engl J Med 2003 349 : 2483 2494.
5. Sezer O. Myeloma bone disease : recent advances in biology, diagnosis and treatment. Oncologist 2009 14 : 276 283.
6. Politou MC, Heath DJ, Rahemtullah A, Szydlo R, Anagnostopoulos A, Dimopoulos MA, Croucher PI, Terpos E. Serum concentrations of Dickkopf-1 protein are increased in patients with Multiple Myeloma and reduced after autologous stem cell transplantation. Int J Cancer 2006 119 : 1728 1731.