Anti-tumor activity of Erythrina variegata L. extract and its mechanism of action

Yaoxue Xuebao

Volumn 44, Issue 12, 2009, Pages 1359-1363

  Zhang, Hong ^a   Xiang, Jun Feng ^a   Tan, Li ^a   Dai, Wei ^a   Bai, Ge ^b   Liu, Yan ^a   Cao, Xue Li ^b   Tang, Ya Lin ^a  

^a INSTITUTE OF CHEMISTRY   (China)

^b BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY   (China)

Author keywords

Anti tumor activity; Erythrina variegata L.; G quadruplex

Indexed keywords

CISPLATIN; ERYTHRINA EXTRACT; ERYTHRINA VARIEGATA EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; ERYTHRINA; ERYTHRINA VARIEGATA; GROWTH CURVE; HUMAN; HUMAN CELL; LEWIS CARCINOMA; MOUSE; NONHUMAN;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARCINOMA, LEWIS LUNG; CELL LINE, TUMOR; CELL PROLIFERATION; DRUGS, CHINESE HERBAL; ERYTHRINA; G-QUADRUPLEXES; HUMANS; MALE; MICE; MICE, INBRED C57BL; PLANTS, MEDICINAL; TUMOR BURDEN;

EID: 76249105507     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Ghosal S, Dutta SK, Bhattacharya SK. Erythrina-chemical and pharmacological evaluation 11: alkaloids of Erythrina variegata L. [J]. J Pharm Sci, 1972, 61: 1274-1277.
2. García-Mateos R, Soto-hernandez M, Martinez-vazquez M, et al. Isolation of alkaloids of erythrina from tissue culture [J]. Phytochem Anal, 1999, 10: 12-16.
3. Wätjen W, Kulawik A, Suckow-schnitker AK, et al. Pterocarpans phaseollin and neorautenol isolated from Erythrina addisoniae induce apoptotic cell death accompanied by inhibition of ERK phosphorylation [J]. Toxicology, 2007, 242: 71-79.
4. Cui L, Thuong PT, Lee HS, et al. Flavanones from the stem bark of Erythrina abyssinica [J]. Bioorg Med Chem, 2008, 16: 10356-10362.
5. Wang S, El-Deiry WS. TRAIL and apoptosis induction by TNF-family death receptors [J]. Oncogene, 2003, 22: 8628-8633.
6. Ozawa M, Etoh T, Hayashi M, et al. TRAIL-enhancing activity of Erythrinan alkaloids from Erythrina velutina [J]. Bioorg Med Chem Lett, 2009, 19: 234-236.
7. Pietroa AD, Conseila G, Pérez-Victoria JM, et al. Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters [J]. Cell Mol Life Sci, 2002, 59: 307-322.
8. Tang YL, Tan L, Dai W, et al. The new anti-tumor application of Erythrina variegata L. extract: China, 200810115667.0 [P]. 2008-10-11.
9. Jenkins TC. Targeting multi-stranded DNA structures [J]. Curr Med Chem, 2000, 7: 99-115.
10. Saretzki G. Telomerase inhibition as cancer therapy [J]. Cancer Lett, 2003, 194: 209-219.
11. Kim NW, Piatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer [J]. Science, 1994, 266: 2011-2015.
12. Evonne MR, David JB, Hurley LH. Telomeres and telomerases as drug targets [J]. Curr Opin Pharmacol, 2002: 415-423.
13. Mita H, Ohyama T, Tanaka Y, et al. Formation of a complex of 5, 10, 15, 20-tetrakis (N-methylpyridinium-4-yl)-21H, 23H-porphyrin with G-quadruplex DNA [J]. Biochemistry, 2006, 45: 6765-6772.
14. Fedoroff OY, Salazar M, Han HY, et al. NMR-based model of a telomerase-inhibiting compound bound to G-quadruplex DNA [J]. Biochemistry, 1998, 37: 12367-12374.
15. Rachwal PA, Fox KR. Quadruplex melting [J]. Methods, 2007, 43: 291-301.
16. Fu B, Huang J, Ren L, et al. Cationic corrole derivatives: a new family of G-quadruplex inducing and stabilizing ligands [J]. Chem Commun, 2007, 31: 3264-3266.
17. Balagurumoothy P, Brahmachari SK, Mohanty D, et al. Hairpin and parallel quartet structures for telomeric sequences [J]. Nucleic Acids Res, 1992, 20: 4061-4067.