Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron

Journal of Psychopharmacology

Volumn 24, Issue 1, 2010, Pages 65-72

  Jacobs, Gabriël E ^a,b   Kamerling, I M C ^a   De Kam, M L ^a   Derijk, R H ^c   Van Pelt, J ^b   Zitman, F G ^a   Van Gerven, J M A ^a  

^a CENTRE FOR HUMAN DRUG RESEARCH   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c LEIDEN UNIVERSITY   (Netherlands)

Author keywords

5 HTP; Challenge test; Granisetron; HPA axis; Pharmacodynamics; Pharmacokinetics; Serotonergic function

Indexed keywords

5 HYDROXYTRYPTOPHAN; CARBIDOPA; DOMPERIDONE; GRANISETRON; HYDROCORTISONE; PLACEBO; PROLACTIN;

ADD ON THERAPY; ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG INDUCED HEADACHE; DRUG TOLERABILITY; HUMAN; HYDROCORTISONE BLOOD LEVEL; MALE; MAXIMUM PLASMA CONCENTRATION; NAUSEA; NORMAL HUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROLACTIN BLOOD LEVEL; PROVOCATION TEST; RANDOMIZED CONTROLLED TRIAL; RELIABILITY; STATISTICAL SIGNIFICANCE; VISUAL ANALOG SCALE; VOMITING;

5-HYDROXYTRYPTOPHAN; ADOLESCENT; ADULT; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; ANTIEMETICS; AREA UNDER CURVE; CARBIDOPA; CROSS-OVER STUDIES; DOMPERIDONE; DOPAMINE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG INTERACTIONS; GRANISETRON; HUMANS; HYDROCORTISONE; MALE; NAUSEA; PROLACTIN; VOMITING; YOUNG ADULT;

EID: 76249098730     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881108094299     Document Type: Article

References (18)

1. Arrindell, WA, Ettema, JHM (1986) SCL-90. Handleiding bij een multidimensionele psychopathologie-indicator. Swets and Zeitlinger, Lisse.
2. Bond, A., Lader, M. (1974) The use of analogue scale in rating subjective feelings. Br J Med Psychol 47: 211-218.
3. Derogatis, LR, Lipman, RS, Covi, L. (1973) SCL-90: an outpatient psychiatric rating scale-preliminary report. Psychopharmacol Bull 9: 13-28.
4. Dumont, GJ, de Visser, SJ, Cohen, AF, Van Gerven, JM (2005) Bio-markers for the effects of selective serotonin reuptake inhibitors (SSRIs) in healthy subjects. Br J Clin Pharmacol 59: 495-510.
5. Endo, T., Minami, M., Hirafuji, M., Ogawa, T., Akita, K., Nemoto, M., et al. (2000) Neurochemistry and neuropharmacology of emesis- the role of serotonin. Toxicology 153: 189-201.
6. Gartside, SE, Cowen, PJ (1990) Mediation of ACTH and prolactin responses to 5-HTP by 5-HT2 receptors. Eur J Pharmacol 179: 103-109.
7. Gijsman, HJ, Van Gerven, JM, Tieleman, MC, Schoemaker, RC, Pieters, MS, Ferrari, MD, et al. (1998) Pharmacokinetic and pharmacodynamic profile of oral and intravenous metachlorophenylpiperazine in healthy volunteers. J Clin Psychopharmacol 18: 289-295.
8. Gijsman, HJ, van Gerven, JMA, de Kam, ML, Schoemaker, RC, Pieters, MSM, Weemaes, M., et al. (2002) Placebo-controlled comparison of three dose-regimens of 5-hydroxytryptophan challenge test in healthy volunteers. J Clin Psychopharmacol 22: 183-189.
9. Groenestijn, MAC, Akkerhuis, GW, Kupka, RW, Schneider, Nolen, WA (1999) Structured clinical interview for DSM-IV axis I disorders. Swets Test, Lisse.
10. Jorgensen, H., Knigge, U., Kjaer, A., Moller, M., Warberg, J. (2002) Serotonergic stimulation of corticotropin-releasing hormone and pro-opiomelanocortin gene expression. J Neuroendocrinol 14: 788-795.
11. Lowe, SL, Yeo, KP, Teng, L., Soon, DK, Pan, A., Wise, SD, et al. (2006) L-5-Hydroxytryptophan augments the neuroendocrine response to a SSRI. Psychoneuroendocrinology 31: 473-484.
12. Mitchelson, F. (1992) Pharmacological agents affecting emesis. A review (Part I). Drugs 43: 295-315.
13. Norris, H. (1971) The action of sedatives on brain stem oculomotor systems in man. Neuropharmacology 10: 181-191.
14. Sanger, GJ, Andrews, PL (2006) Treatment of nausea and vomiting: gaps in our knowledge. Auton Neurosci 129: 3-16.
15. Sargent, PA, Williamson, DJ, Cowen, PJ (1998) Brain 5-HT neuro-transmission during paroxetine treatment. Br J Psychiatry 172: 49-52.
16. Smarius, Ljca, Jacobs, GE, Hoeberechts-Lefrandt, DHM, de Kam, ML, van der Post, J., de Rijk, R., et al. (2008) Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa. J Psychopharmacol OnlineFirst, February 28, 2008.
17. Tan, M. (2003) Granisetron: new insights into its use for the treatment of chemotherapy-induced nausea and vomiting. Expert Opin Pharmacother 4: 1563-1571.
18. Van de Kar, LD, Rittenhouse, PA, Li, Q., Levy, AD (1996) Serotonergic regulation of renin and prolactin secretion. Behav Brain Res 73: 203-208.