Mechanism of phosphate-induced calcification in rat aortic tissue culture: Possible involvement of Pit-1 and apoptosis

Clinical and Experimental Nephrology

Volumn 13, Issue 6, 2009, Pages 571-577

  Mune, Sachiko ^a   Shibata, Maki ^a   Hatamura, Ikuji ^a   Saji, Fumie ^a   Okada, Tadashi ^a   Maeda, Yuka ^a   Sakaguchi, Toshifumi ^a   Negi, Shigeo ^a   Shigematsu, Takashi ^a  

^a WAKAYAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Apoptosis; Inorganic phosphate (Pi); Type III sodium dependent phosphate cotransporter (Pit 1); Vascular calcification

Indexed keywords

CASPASE 3; FOSCARNET; PHOSPHATE; SLC20A1 PROTEIN, RAT; SODIUM PHOSPHATE COTRANSPORTER 3;

ANIMAL; AORTA; APOPTOSIS; ARTICLE; CALCINOSIS; CHEMICALLY INDUCED DISORDER; MALE; METABOLISM; NICK END LABELING; PATHOLOGY; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT; TISSUE CULTURE TECHNIQUE; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA; APOPTOSIS; CALCINOSIS; CASPASE 3; FOSCARNET; IN SITU NICK-END LABELING; MALE; MUSCLE, SMOOTH, VASCULAR; PHOSPHATES; RATS; RATS, SPRAGUE-DAWLEY; SODIUM-PHOSPHATE COTRANSPORTER PROTEINS, TYPE III; TISSUE CULTURE TECHNIQUES;

EID: 76249095304     PISSN: 13421751     EISSN: 14377799     Source Type: Journal    
DOI: 10.1007/s10157-009-0208-0     Document Type: Article

References (21)

1. Blacher J, Guerin AP, Pannier B, Marchais SJ, London GM. Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease. Hypertension. 2001;38:938-42. (Pubitemid 34258697)
2. London GM, Guerin AP, Marchais SJ, Métivier F, Pannier B, Adda H. Arterial media calcification in end-stage renal disease. Nephrol Dial Transplant. 2003;18:1731-40.
3. United States Renal Data System. USRDS 2007 Annual data report. Available at: http://www.usrds.org/2007/pdf/06-hosp-morte-07.pdf.
4. Block GA, Klassen PS, Lazarus JM, Ofsthun N, Lowrie EG, Chertow GM. Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. J Am Soc Nephrol. 2004;15:2208-18. (Pubitemid 39031360)
5. Goodman WG, Goldin J, Kuizon BD, Yoon C, Gales B, Sider D, et al. Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med. 2000;342:1478-83. (Pubitemid 30318271)
6. Raggi P, Boulay A, Chasan-Taber S, Amin N, Dillon M, Burke SK, et al. Cardiac calcification in adult hemodialysis patients. J Am Coll Cardiol. 2002;39:695-701.
7. Steiz SA, Speer MY, Curinga G, Yang HY, Haynes P, Aebersold R, et al. Smooth muscle cell phenotypic transition associated with calcification. Circ Res. 2001;89:1147-54.
8. Chen NX, O'Neill KD, Duan D, Moe SM. Phosphorus and uremic serum up-regulate osteopontin expression in vascular smooth muscle cells. Kidney Int. 2002;62:1724-31. (Pubitemid 35286280)
9. Jono S, McKee MD, Murry CE, Shioi A, Nishizawa Y, Mori K, et al. Phosphate regulation of vascular smooth muscle cell calcification. Circ Res. 2000;87:e10-7.
10. Li X, Yang HY, Giachelli CM. Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification. Circ Res. 2006;98:905-12.
11. Proudfoot D, Skepper JN, Hegyi L, Bennett MR, Shanahan CM, Weissberg PL. Apoptosis regulates human vascular calcification in vitro. Circ Res. 2000;87:1055-62.
12. Reynolds JL, Joannides AJ, Skepper JN, McNair R, Schurgers LJ, Proudfoot D, et al. Human vascular smooth muscle cells undergo vesicle mediated calcification in response to changes in extracellular calcium and phosphate concentrations. J Am Soc Nephrol. 2004;15:2857-67. (Pubitemid 41103395)
13. Son BK, Kozaki K, Iijima K, Eto M, Kojima T, Ota H, et al. Statins protect human aortic smooth muscle cells from inorganic phosphate-induced calcification by restoring Gas6-Axl survival pathway. Circ Res. 2006;98:1024-31.
14. Schoppet M, Al-Fakhri N, Franke FE, Katz N, Barth PJ, Maisch B, et al. Localization of osteoprotegerin, tumor necrosis factor-related apoptosis-inducing ligand, and receptor activator of nuclear factor-κB ligand in Mönckeberg's sclerosis and atherosclerosis. J Clin Endocrinol Metab. 2004;89:4104-12. (Pubitemid 39071519)
15. Lomashvili KA, Cobbs S, Hennigar RA, Hardcastle KI, O'Neill WC. Phosphate-induced vascular calcification. J Am Soc Nephrol. 2004;15:1392-401.
16. Price PA, Chan WS, Jolson DM, Williamson MK. The elastic lamellae of devitalized arteries calcify when incubated in serum. Arterioscler Thromb Vasc Biol. 2006;26:1079-85.
17. Lomashvili KA, Garg P, O'Neill WC. Chemical and hormonal determinants of vascular calcification. Kidney Int. 2006;69:1464-70.
18. Mizobuchi M, Ogata H, Hatamura I, Koiwa F, Saji F, Shiizaki K, et al. Up-regulation of Cbfa1 and Pit-1 in calcified artery of uraemic rats with severe hyperphosphataemia and secondary hyperparathyroidism. Nephrol Dial Transplant. 2006;21:911-6.
19. Meleti Z, Shapiro IM, Adams CS. Inorganic phosphate induces apoptosis of osteoblast-like cells in culture. Bone. 2000;27:359-66. (Pubitemid 30658118)
20. Magne D, Bluteau G, Faucheux C, Palmer G, Vignes-Colombeix C, Pilet P, et al. Phosphate is a specific signal for ATDC5 chondrocyte maturation and apoptosis-associated mineralization. J Bone Miner Res. 2003;18:1430-42.
21. Oshima Y, Akiyama T, Hikita A, Iwasawa M, Nagase Y, Nakamura M, et al. Pivotal role of Bcl-2 family proteins in the regulation of chindrocyte apoptosis. J Biol Chem. 2008;283:26499-508.