Metabolic, cardiovascular, and cerebrovascular outcomes in growth hormone-deficient subjects with previous cushing's disease or non-functioning pituitary adenoma

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 2, 2010, Pages 630-638

  Webb, Susan M ^a   Mo, Daojun ^b   Lamberts, Steven W J ^c   Melmed, Shlomo ^d   Cavagnini, Francesco ^e   Giraldi, Francesca Pecori ^e   Strasburger, Christian J ^f   Zimmermann, Alan G ^b   Woodmansee, Whitney W ^g  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b ELI LILLY AND COMPANY   (United States)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d CEDARS SINAI MEDICAL CENTER   (United States)

^e UNIVERSITY OF MILAN   (Italy)

^f CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^g BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CEREBROVASCULAR DISEASE; CUSHING DISEASE; DISEASE ASSOCIATION; FEMALE; GROWTH HORMONE DEFICIENCY; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; NONFUNCTIONING PITUITARY ADENOMA; OBSERVATIONAL STUDY; POST HOC ANALYSIS; PREVALENCE; PRIORITY JOURNAL;

EID: 76149137381     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-0806     Document Type: Article

References (34)

1. Arnaldi G, Angeli A, Atkinson AB, Bertagna X, Cavagnini F, Chrousos GP, Fava GA, Findling JW, Gaillard RC, Grossman AB, Kola B, Lacroix A, Mancini T, Mantero F, Newell-Price J, Nieman LK, Sonino N, Vance ML, Giustina A, Boscaro M 2003 Diagnosis and complications of Cushing's syndrome: a consensus statement. J Clin Endocrinol Metab 88:5593-5602
2. Biller BM, Grossman AB, Stewart PM, Melmed S, Bertagna X, Bertherat J, Buchfelder M, Colao A, Hermus AR, Hofland LJ, Klibanski A, Lacroix A, Lindsay JR, Newell-Price J, Nieman LK, Petersenn S, Sonino N, Stalla GK, Swearingen B, Vance ML, Wass JA, Boscaro M 2008 Treatment of adrenocorticotropin-dependent Cushing's syndrome: a consensus statement. J Clin Endocrinol Metab 93:2454-2462
3. Boscaro M, Barzon L, Fallo F, Sonino N 2001 Cushing's syndrome. Lancet 357:783-791
4. Mancini T, Kola B, Mantero F, Boscaro M, Arnaldi G 2004 High cardiovascular risk in patients with Cushing's syndrome according to 1999 WHO/ISH guidelines. Clin Endocrinol (Oxf) 61:768-777
5. National Cholesterol Education Program (NCEP) Expert Panel 2002 Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 106:3143-3421
6. Pivonello R, Faggiano A, Lombardi G, Colao A2005 The metabolic syndrome and cardiovascular risk in Cushing's syndrome. Endocrinol Metab Clin North Am 34:327-339, viii
7. Utz AL, Swearingen B, Biller BM 2005 Pituitary surgery and postoperative management in Cushing's disease. Endocrinol Metab Clin North Am 34:459-478, xi
8. Vance ML 2009 Cushing's disease: radiation therapy. Pituitary 12:11-14
9. Tzanela M, Karavitaki N, Stylianidou C, Tsagarakis S, Thalassinos NC2004 Assessment of GH reserve before and after successful treatment of adult patients with Cushing's syndrome. Clin Endocrinol (Oxf) 60:309-314
10. Hughes NR, Lissett CA, Shalet SM 1999 Growth hormone status following treatment for Cushing's syndrome. Clin Endocrinol (Oxf) 51:61-66
11. Rees DA, Hanna FW, Davies JS, Mills RG, Vafidis J, Scanlon MF 2002 Long-term follow-up results of transsphenoidal surgery for Cushing's disease in a single centre using strict criteria for remission. Clin Endocrinol (Oxf) 56:541-551
12. Pecori Giraldi F, Andrioli M, De Marinis L, Bianchi A, Giampietro A, De Martin M, Sacco E, Scacchi M, Pontecorvi A, Cavagnini F 2007 Significant GH deficiency after long-term cure by surgery in adult patients with Cushing's disease. Eur J Endocrinol 156:233-239
13. McCallum RW, Petrie JR, Dominiczak AF, Connell JM 2002 Growth hormone deficiency and vascular risk. Clin Endocrinol (Oxf) 57:11-24
14. van der Klaauw AA, Biermasz NR, Feskens EJ, Bos MB, Smit JW, Roelfsema F, Corssmit EP, Pijl H, Romijn JA, Pereira AM 2007 The prevalence of the metabolic syndrome is increased in patients with GH deficiency, irrespective of long-term substitution with recombinant human GH. Eur J Endocrinol 156:455-462
15. Svensson J, Bengtsson BA, Rosén T, Odén A, Johannsson G 2004 Malignant disease and cardiovascular morbidity in hypopituitary adults with or without growth hormone replacement therapy. J Clin Endocrinol Metab 89:3306-3312
16. Colao A, Pivonello R, Spiezia S, Faggiano A, Ferone D, Filippella M, Marzullo P, Cerbone G, Siciliani M, Lombardi G 1999 Persistence of increased cardiovascular risk in patients with Cushing's disease after five years of successful cure. J Clin Endocrinol Metab 84:2664-2672
17. Colson A, Brooke AM, Walker D, Besser GM, Chew SL, Grossman AB, Jenkins PJ, Drake WM, Monson JP 2006 Growth hormone deficiency and replacement in patients with treated Cushing's disease, prolactinomas and non-functioning pituitary adenomas: effects on body composition, glucose metabolism, lipid status and bone mineral density. Horm Res 66:257-267
18. Feldt-Rasmussen U, Abs R, Bengtsson BA, Bennmarker H, Bramnert M, Hernberg-Ståhl E, Monson JP, Westberg B, Wilton P, Wüster C 2002 Growth hormone deficiency and replacement in hypopituitary patients previously treated for acromegaly or Cushing's disease. Eur J Endocrinol 146:67-74
19. Webb SM, Strasburger CJ, Mo D, Hartman ML, Melmed S, Jung H, Blum WF, Attanasio AF 2009 Changing patterns of the adult growth hormone deficiency diagnosis documented in a decade-long global surveillance database. J Clin Endocrinol Metab 94:392-399
20. Attanasio AF, Bates PC, Ho KK, Webb SM, Ross RJ, Strasburger CJ, Bouillon R, Crowe B, Selander K, Valle D, Lamberts SW 2002 Human growth hormone replacement in adult hypopituitary patients: long-term effects on body composition and lipid status-3-year results from the HypoCCS Database. J Clin Endocrinol Metab 87:1600-1606
21. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith Jr SC, Spertus JA, Costa F 2005 Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 112:2735-2752
22. Biller BM, Samuels MH, Zagar A, Cook DM, Arafah BM, Bonert V, Stavrou S, Kleinberg DL, Chipman JJ, Hartman ML 2002 Sensitivity and specificity of six tests for the diagnosis of adult GH deficiency. J Clin Endocrinol Metab 87:2067-2079
23. Blum WF, Breier BH 1994 Radioimmunoassays for IGFs and IGFBPs. Growth Regul 4(Suppl 1):11-19
24. Blum WF, Schweizer R 2003 Insulin-like growth factors and their binding proteins. In: Ranke MB, ed. Diagnostics of endocrine function in children and adolescents. Basel, Switzerland: S. Karger Publishers; 166-199
25. Breslow NE, Day NE 1987 Statistical methods in cancer research. Vol. II. The design and analysis of cohort studies. IARC Scientific Publication no. 82. Lyon, France: International Agency for Research on Cancer
26. Pasquali R, Vicennati V, Cacciari M, Pagotto U 2006 The hypothalamic-pituitary-adrenal axis activity in obesity and the metabolic syndrome. Ann NY Acad Sci 1083:111-128
27. Wajchenberg BL 2000 Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 21:697-738
28. Whitworth JA, Williamson PM, Mangos G, Kelly JJ 2005 Cardiovascular consequences of cortisol excess. Vasc Health Risk Manag 1:291-299
29. Faggiano A, Pivonello R, Spiezia S, De Martino MC, Filippella M, Di Somma C, Lombardi G, Colao A 2003 Cardiovascular risk factors and common carotid artery caliber and stiffness in patients with Cushing's disease during active disease and 1 year after disease remission. J Clin Endocrinol Metab 88:2527-2533
30. Barahona MJ, Sucunza N, Resmini E, Fernández-Real JM, Ricart W, Moreno-Navarrete JM, Puig T, Farrerons J, Webb SM 2009 Persistent body fat mass and inflammatory marker increases after long-term cure of Cushing's syndrome. J Clin Endocrinol Metab 94:3365-3371
31. Ford ES, Giles WH, Mokdad AH 2004 Increasing prevalence of the metabolic syndrome among U.S. adults. Diabetes Care 27:2444-2449
32. Ayuk J, Stewart PM 2009 Mortality following pituitary radiotherapy. Pituitary 12:35-39
33. Johannsson G, Sunnerhagen KS, Svensson J 2004 Baseline characteristics and the effects of two years of growth hormone replacement therapy in adults with growth hormone deficiency previously treated for Cushing's disease. Clin Endocrinol (Oxf) 60:550-559
34. Dekkers OM, Biermasz NR, Pereira AM, Roelfsema F, van Aken MO, Voormolen JH, Romijn JA 2007 Mortality in patients treated for Cushing's disease is increased, compared with patients treated for non-functioning pituitary macroadenoma. J Clin Endocrinol Metab 92:976-981