Metabolic programming of lipid profile and reproductive organs weight by leptin treatment on early life

Acta Cirurgica Brasileira

Volumn 25, Issue 1, 2010, Pages 55-58

  Marques, Durval Santos ^a   Gombar, Flávia Meireles ^a   Pereira, Jorge Luiz Alves ^a   Sampaio, Francisco José Barcellos ^a   Ramos, Cristiane Da Fonte ^a  

^a STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Lactation; Leptin; Organ size; Rats

Indexed keywords

RECOMBINANT LEPTIN; TRIACYLGLYCEROL; LEPTIN; LIPID;

ARTICLE; BODY WEIGHT; FOOD INTAKE; LACTATION; LIPID METABOLISM; MALE GENITAL SYSTEM; ORGAN WEIGHT; ANATOMY AND HISTOLOGY; ANIMAL; ANIMAL MODEL; DRUG EFFECTS; MALE; NEWBORN; ORGAN SIZE; PHYSIOLOGY; RANDOMIZATION; RAT; SUCKLING ANIMAL; WISTAR RAT;

ANIMALS; ANIMALS, NEWBORN; ANIMALS, SUCKLING; GENITALIA, MALE; LEPTIN; LIPIDS; MALE; MODELS, ANIMAL; ORGAN SIZE; RANDOM ALLOCATION; RATS; RATS, WISTAR;

EID: 76149135389     PISSN: 01028650     EISSN: 16782674     Source Type: Journal    
DOI: 10.1590/s0102-86502010000100013     Document Type: Article

References (15)

1. Magni P, Motta M, Martini L. Leptin: a possible link between food intake, energy expenditure, and reproductive function. Regul Pept. 2000;92(1-3):51-6.
2. Frühbeck G, Jebb SA, Prentice AM. Leptin physiology and pathophysiology. Clin Physiol. 1998;18(5):399-419.
3. Frisch RE. The right weight: body fat, menarche and ovulation. Ballières Clin Gynaecol. 1990;4(3):419-39.
4. Chan JL, Matarese G, Shetty GK. Differential regulation of metabolic, neuroendocrine, and immune function by leptin in humans. Proc Natl Acad Sci USA. 2006;103(22):8481-6.
5. Farooqi S, Wangensteen T, Collins S. Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. N Engl J Med. 2007;356(3):237-47.
6. Hegyi K, Fulop K, Kovacs K, Toth S, Falus A. Leptin-induced signal transduction pathways. Cell Biol Int. 2004;28:159-69.
7. Molina-Carballo A, Fernandez-Tardaguila E, Uberos-Fernandez J. Longitudinal study of the simultaneous secretion of melatonin and leptin duringnormal puberty. Horm Res. 2007;68:11-9.
8. Fischbeck KL, Rasmussen KM. Effect of repeated reproductive cycles on maternal nutritional status, lactational performance and litter growth in ad libitum-fed and chronically food-restricted rats, J Nutr. 1987;117(11):1967-75.
9. Dörner G, Plagemann A. A Perinatal hyperinsulinism as possible predisposing factor for diabetes mellitus, obesity and enhanced cardiovascular risk in later life. Horm Metab Res. 1994;26(5):213-21.
10. Cravo CO, Teixeira CV, Passos MC, Dutra SC, Moura EG, Ramos C. Leptin treatment during the neonatal period is associated with higher food intake and adult body weight in rats. Horm Metab Res. 2002;34(7):400-5.
11. Bayne K. Revised guide for the care and use of laboratory animals available. Am Phys Soc Physiol. 1996;39(4):199:208-11.
12. Malendowicz LK, Macchi C, Nussdorfer GG, Nowak KW.- Acute effects of recombinant murine leptin on rat pituitary-adrenocortical function. Endocr Res. 1998;24(2):235-46.
13. Reidy SP, Weber J. Leptin: an essential regulator of lipid metabolism. Comp Biochem Physiol A Mol Integr Physiol. 2000;125(3):285-98.
14. VanPatten S, Ranginani N, Shefer S, Nguyen LB, Rossetti L, Cohen DE. Impaired biliary lipid secretion in obese Zucker rats: leptin promotes hepatic cholesterol clearance. Am J Physiol Gastrointest Liver Physiol. 2001;281(2):G393-404.
15. Prieur X, Tung YC, Griffin JL, Farooqi IS, O'Rahilly S, Coll AP. Leptin regulates peripheral lipid metabolism primarily through central effects on food intake. Endocrinology. 2008;149(11):5432-9.