Off-label use of recombinant IGF-I to promote growth: Is it appropriate?

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 2, 2010, Pages 505-508

  Rosenbloom, Arlan L ^a   Rivkees, Scott A ^b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT SOMATOMEDIN C;

CHILD GROWTH; EDITORIAL; GROWTH DISORDER; GROWTH RETARDATION; HORMONAL THERAPY; HUMAN; OFF LABEL DRUG USE; PRIORITY JOURNAL; SHORT STATURE;

EID: 76149129693     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-2450     Document Type: Editorial

References (20)

1. Chernausek SD, Backeljauw PF, Frane J, Kuntze J, Underwood LE; GH Insensitivity Syndrome Collaborative Group 2007 Long-term treatment with recombinant IGF-I in children with severe IGF-I deficiency due to growth hormone insensitivity. J Clin Endocrinol Metab 92:902-910
2. Tercica Securities and exchange commission. Amendment 5 to form S-1. Registration statement. November 21, 2003: http://trca.client. shareholder.com/EdgarDetail.cfm?CIK=1262175&FID=119312 5-03-85244&SID= 03-00 (accessed May 24, 2006)
3. Rosenbloom AL 2006 Is there a role for recombinant insulin-like growth factor-I (rhIGF-I) in the treatment of idiopathic short stature? Lancet 368:612-616
4. Midyett LK, Rogol AD, Van Meter QL, Frane J. Bright GM, on behalf of the MS301 Study Group 2010 Recombinant insulin-like growth factor (IGF)-I treatment in short children with low IGF-I levels: first year results from a randomized clinical trial. J Clin Endocrinol Metab 95:611-619
5. Hintz RL, Attie KM, Baptista J, Roche A, for the Genentech Collaborative Group 1999 Effect of growth hormone treatment on adult height of children with idiopathic short stature. N Engl J Med 340:502-507
6. Rosenbloom AL 2009 Idiopathic short stature: conundrums of definition and treatment. Int J Pediatr Endocrinol 2009:470378
7. Bryant J, Baxter L, Cave CB, Milne R 2007 Recombinant growth hormone for idiopathic short stature in children and adolescents. Cochrane Database Syst Rev CD004440 (Review)
8. Kemp SF, Kuntze J, Attie KM, Maneatis T, Butler S, Frane J, Lippe B 2005 Efficacy and safety results of long-term growth hormone treatment of idiopathic short stature. J Clin Endocrinol Metab 90: 5247-5253
9. Albertsson-Wikland K,Aronson AS, Gustafsson J, Hagenäs L, Ivarsson SA, Jonsson B, Kriström B, Marcus C, Nilsson KO, Ritzén EM, Tuvemo T, Westphal O, Aman J 2008 Dose-dependent effect of growth hormone on final height in children with short stature without growth hormone deficiency. J Clin Endocrinol Metab 93:4342-4350
10. Spiliotis BE, Alexandrides TK, Karystianos C, Vassilakos P, Zadik Z, Nikolakopoulou NM, Nikiforidis G, Beratis NG 2009 The insulin-like growth factor-I (IGF-I) generation test as an indicator of growth hormone status. Hormones (Athens) 8:117-128
11. Buckway CK, Guevara-Aguirre J, Pratt KL, Burren CP, Rosenfeld RG 2001 The IGF-I generation test revisited: a marker of GH sensitivity. J Clin Endocrinol Metab 86:5176-5183
12. Park P, Cohen P 2005 Insulin-like growth factor I (IGF-I) measurements in growth hormone (GH) therapy of idiopathic short stature (ISS). Growth Horm IGF Res 15(Suppl A):S13-S20
13. Moore WV, Dana K, Frane J, Lippe B 2008 Growth hormone responsiveness: Peak stimulated growth hormone levels and other variables in idiopathic short stature (ISS): data from the National Cooperative Growth Study. Pediatr Endocrinol Rev 6:5-8
14. Guevara-Aguirre J, Rosenbloom AL, Vasconez O, Martinez V, Gargosky SE, Allen L, Rosenfeld RG 1997 Two year treatment of growth hormone receptor deficiency (GHRD) with recombinant insulin-like growth factor-I in 22 children: comparison of two dosage levels and to GH treated GH deficiency. J Clin Endocrinol Metab 82:629-633
15. Leschek EW, Rose SR, Yanovski JA, Troendle JF, Quigley CA, Chipman JJ, Crowe BJ, Ross JL, Cassorla FG, Blum WF, Cutler Jr GB, Baron J; National Institute of Child Health and Human Development-Eli Lilly, Co. Growth Hormone Collaborative Group 2004 Effect of growth hormone treatment on adult height in peripubertal children with idiopathic short stature: a randomized, double-blind, placebo-controlled trial. J Clin Endocrinol Metab 89:3140-3148
16. Darendililer F, Karagiannis G, Wilton P 2007 Headache, idiopathic intracranial hypertension and slipped capital femoral differences during growth hormone treatment: a safety update from the KIGS database. Horm Res 68(Suppl 5):41-47
17. Blethen SL, Allen DB, Graves D, August G, Moshang T, Rosenfeld RG, on behalf of the National Cooperative Growth Study 1996 Safety of recombinant deoxyribonucleic acid-derived growth hormone: the National Cooperative Growth Study experience. J Clin Endocrinol Metab 81:1704-1710
18. Torjusen E, Calderon J, Rivkees SA 2008 Anaphylactic reaction to recombinant insulin like growth factor-I. J Pediatr Endocrinol Metab 21:381-384
19. Metz KA, Assa'ad A, Lierl MB, Backeljauw P 2009 Allergic reaction to mecasermin. Ann Allergy Asthma Immunol 103:82-83
20. Phamapendium 2009 Postmarketing reports for mecasermin. https://www.pharmapendium.com