Assessment of in vitro methodologies to determine topical and transdermal delivery of the flavonoid quercetin

Brazilian Journal of Pharmaceutical Sciences

Volumn 45, Issue 2, 2009, Pages 357-364

  Vicentini, Fabiana Testa Moura De Carvalho ^a   Georgetti, Sandra Regina ^a   Bentley, Maria Vitória Lopes Badra ^a   Fonseca, Maria José Vieira ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

DPPH ; High performance liquid chromatography; Quercetin extraction; Quercetin liberation; Quercetin quantification; Skin penetration in vitro study; Topical formulations analysis

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; DICHLOROMETHANE; FLAVONOID; QUERCETIN; SOLVENT;

ACCURACY; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG ISOLATION; DRUG PENETRATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; METHODOLOGY; NONHUMAN; SKIN PENETRATION;

EID: 76149119132     PISSN: 19848250     EISSN: 21759790     Source Type: Journal    
DOI: 10.1590/S1984-82502009000200022     Document Type: Article

References (22)

1. BLOIS, M.S. Antioxidant determinations by use of a stable free radical. Nature, London, v.181, p.1199-1200, 1958.
2. BONINA, F.; LANZA, M.; MONTENEGRO, L.; PUGLISI, C.; TOMAINO, A.; TROMBETTA, D.; CASTELLI, F.; SAIJA, A. Flavonoids as potential protective agents against photo-oxidative skin damage. Int. J. Pharm., Amsterdam, v.145, p.87-94, 1996.
3. BOUDJELAL, M.; WANG, Z.; VOORHEES, J.J.; FISHER, G.J. Ubiquitin/proteasome pathway regulates levels of retinoic acid receptor gamma and retinoid X receptor alpha in human keratinocytes. Cancer Res., Baltimore, v.60, p.2247-2252, 2000.
4. CARERI, M.; ELVIRI, L.; MANGIA, A.; MUSCI, M. Spectrophotometric and coulometric detection in the high-performance liquid chromatography of flavonoids and optimization of sample treatment for the determination of quercetin in orange juice. J. Chromatogr. A, Amsterdam, v.881, p.449-460, 2000.
5. CASAGRANDE, R.; GEORGETTI, S.R.; VERRI JR, W.A.; BORIN, M.F.; LOPEZ, R.F.V.; FONSECA, M.J.V. In vitro evaluation of quercetin cutaneous absorption from topical formulations and its functional stability by antioxidant activity. Int. J. Pharm., Amsterdam, v.328, p.183-190, 2007.
6. CASAGRANDE, R.; GEORGETTI, S.R.; VERRI JR, W.A.; DORTA, D.J.; dos SANTOS, A.C.; FONSECA, M.J.V. Protective effect of topical formulations containing quercetin against UVB-induced oxidative stress in hairless mice. J. Photochem. Photobiol. B, Lausanne, v.84, p.21-27, 2006a.
7. CASAGRANDE, R.; GEORGETTI, S.R.; VERRI JR, W.A.; JABOR, J.R.; SANTOS, A.C.; FONSECA, M.J.V. Evaluation of functional stability of quercetin as a raw material and in different topical formulations by its antilipoperoxidative activity. AAPS PharmSci. [serial online], Arlington, v.7, p.E1-E8, 2006b.
8. DINIS, T.C.P.; MADEIRA, V.M.C.; ALMEIDA, L.M. Action of phenolic derivates (acetaminophen, salicylate, and 5-aminosalicylate) as inhibitors of membrane lipid peroxidation and as peroxyl radical scavengers. Arch. Biochem. Biophys., New York, v.315, p.161-169, 1994.
9. GEORGETTI, S.R.; CASAGRANDE, R.; DI MAMBRO, V.M.; AZZOLINI, A.E.C.S.; FONSECA, M.J.V. Evaluation of the antioxidant activity of different flavonoids by the chemiluminescence method. AAPS PharmSci. [serial online], Arlington, v.5, p.1-5, 2003.
10. LOPES, L.B.; BENTLEY, M.V.L.B. Cyclosporin A in skin samples from in vitro penetration studies may be assayed by a simple HPLC method. Rev. Bras. Ciênc. Farm., São Paulo, v.41, p.477-482, 2005.
11. MOSER, K.; KRIWET, K.; NAIK, A.; KALIA, Y.N.; GUY, R.H. Passive skin penetration enhancement and its quantification in vitro. Eur. J. Pharm. Biopharm., Stuttgart, v.52, p.103-112, 2001.
12. NUUTILA, A.M.; PUUPPONEN-PIMIÄ, R.; AARNI, M.; OKSMAN-CALDENTEY, K.-M. Comparison of antioxidant activities of onion and garlic extracts by inhibition of lipid peroxidation and radical scavenging activity. Food Chem., Barking, v.81, p.485-493, 2003.
13. PINELO, M.; MANZOCCO, L.; NUÑEZ, M.J.; NICOLI, M.C. Solvent effect on quercetin antioxidant capacity. Food Chem., Barking, v.88, p.201-207, 2004.
14. PODDA, M.; TRABER, M.G.; WEBER, C.; YAN, L.J.; PACKER, L. UV-irradiation depletes antioxidants and causes oxidative damage in model of human skin. Free Radic. Biol. Med., New York, v.24, p.55-65, 1998.
15. QUEIROZ, S.C.N.; COLLINS, C.H.; JARDIM, I.C.S.F. Métodos de extração e/ou concentração de compostos encontrados em fluídos biológicos para posterior determinação cromatográfica. Quim. Nova, São Paulo, v.24, p.68-76, 2001.
16. RÖPKE, C.D.; KANEKO, T.M.; RODRIGUES, R.M.; SILVA, V.V.; BARROS, S.; SAWADA, T.C.H.; KATO, M.J.; BARROS, S.B.M. Evaluation of percutaneous absorption of 4-nerolidylcathecol from four topical formulations. Int. J. Pharm., Amsterdam, v. 249, p.109-116, 2002.
17. SAIJA, A.; TOMAINO, A.; TROMBETTA, D.; GIACCHI, M.; DE PASQUALE, A.; BONINA, F. Influence of different penetration enhancers on in vitro skin permeation and in vivo photoprotective effect of flavonoids. Int. J. Pharm., Amsterdam, v.175, p.85-94, 1998.
18. SILVA, M.M.; SANTOS, M.R.; CAROÇO, G.; ROCHA, R.; JUSTINO, G.; MIRA, L. Structure-antioxidant activity relationships of flavonoids: a re-examination. Free Radic. Res., London, v.36, p.1219-1227, 2002.
19. TSIMOGIANNIS, D.I.; OREOPOULOU, V. Free radical scavenging and antioxidant activity of 5,7,3',4' - hydroxy-substituted flavonoids. Innovat. Food Sci. Emerg. Tech., Berlin, v.5, p.523-528, 2004.
20. VICENTINI, F.T.M.C.; CASAGRANDE, R.; GEORGETTI, S.R.; BENTLEY, M.V.L.B.; FONSECA, M.J.V. Influence of vehicle on antioxidant activity of quercetin: a liquid crystalline formulation. Lat. Am. J. Pharm., Buenos Aires, v.26, p.805-810, 2007a.
21. VICENTINI, F.T.M.C.; GEORGETTI, S.R.; JABOR, J.R.; CARIS, J.A.; BENTLEY, M.V.L.B.; FONSECA, M.J.V. Photostability of quercetin under exposure to UV irradiation. Lat. Am. J. Pharm., Buenos Aires, v.26, p.119-124, 2007b.
22. XU, Y.; FISHER, G.J. Ultraviolet (UV) light irradiation induced signal transduction in skin photoaging. J. Dermatol. Sci. Suppl., New York, v.1, p.S1-S8, 2005.