Therapeutic effects of pegylated interferon plus ribavirin in chronic hepatitis C patients with occult hepatitis B virus dual infection

Journal of Gastroenterology and Hepatology (Australia)

Volumn 25, Issue 2, 2010, Pages 259-263

  Chen, Li Wei ^a   Chien, Rong Nan ^a   Yen, Cho Li ^a   Chang, Jia Jang ^a   Liu, Ching Jung ^a   Lin, Chih Lang ^a  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Hepatitis C virus; Occult hepatitis B virus; Pegylated interferon; Ribavirin

Indexed keywords

PEGINTERFERON; RIBAVIRIN; VIRUS DNA; VIRUS RNA;

ADULT; ANEMIA; ARTICLE; CONTROLLED STUDY; DEPRESSION; DNA PROBE; DRUG ERUPTION; FEMALE; FLU LIKE SYNDROME; GENOTYPE; HAIR LOSS; HEPATITIS B; HEPATITIS C; HUMAN; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; OCCULT BLOOD TEST; PRIORITY JOURNAL; RNA PROBE; THROMBOCYTOPENIA; TREATMENT RESPONSE;

EID: 76149102210     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2009.06006.x     Document Type: Article

References (19)

1. Cacciola I, Pollicino T, Squatdrito G, Cerenzia M, Oriando E, Raimondo G. Occult hepatitis B virus infection in patients with chronic hepatitis c liver disease. N. Engl. J. Med. 1999 341 : 22 6.
2. Uchida T, Kaneita Y, Gotoh K et al. Hepatitis C virus is frequently coinfected with serum marker-negative hepatitis B virus: probable replication promotion of the former by the later as demonstrated by vitro cotransfection. J. Med. Virol. 1997 52 : 399 405.
3. Bréchot C, Degos F, Lugassy C et al. Hepatitis B virus DNA in patients with chronic liver disease and negative tests for hepatitis B surface antigen. N. Engl. J. Med. 1985 312 : 270 276.
4. Zhang YY, Hansson BG, Kuo AL, Widell A, Nordenfelt E. Hepatitis B virus DNA in serum and liver is commonly found in Chinese patients with chronic liver disease despite the presence of antibodies to HBsAg. Hepatology 1993 17 : 538 544.
5. Kan JH, Chen PJ, Lai MY, Chen DS. Occult hepatitis B virus infection and clinical outcomes of patients with chronic C. J. Clin. Microbiol. 2002 40 : 4068 4071.
6. Helmy A, Al-Sebayel MI. Isolated antibody to hepatitis B core antigen in patients with chronic hepatitis C virus infection. World J. Gastroenterol. 2006 12 : 4406 4410.
7. Hasegawa I, Orito E, Tanaka Y et al. Impact of occult hepatitis B virus infection on efficacy and prognosis of interferon-α therapy for patients with chronic hepatitis C. Liver Int. 2005 25 : 247 253.
8. Sheen IS, Liaw YF, Lin DY, Chu CM. Role of hepatitis C and delta viruses in the termination of chronic hepatitis B surface antigen carrier state: a multivariate analysis in a longitudinal follow-up study. J. Infect. Dis. 1994 170 : 358 361.
9. Sagnelli E, Coppola N, Scolastico C, Mogavero AR, Filippini P, Piccinino F. HCV genotype and 'silent' HBV co-infection: two main risk factors for a more severe liver disease. J. Med. Virol. 2001 64 : 350 355.
10. Sheu JC, Huang GT, Shih LN et al. Hepatitis C and B viruses in hepatitis B surface antigen-negative hepatocellular carcinoma. Gastroenterology 1992 103 : 1322 1327.
11. Khattab E, Chemin I, Vuillermoa I et al. Analysis of HCV co-infection with occult hepatitis B virus in patients undergoing IFN therapy. J. Clin. Virol. 2005 33 : 150 157.
12. Fried MW, Shiffman M, Reddy KR et al. Peginterferon alpha-2a plus ribavirin for chronic hepatitis C virus infection. N. Engl. J. Med. 2002 347 : 975 982.
13. Hadziyannis SJ, Sette H Jr., Morgan TR, for the PEGASYS International Study Group. Peginterferon-alpha 2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose. Ann. Intern. Med. 2004 140 : 346 355.
14. Zeuzem S, Hultcrantz R, Bourliere M et al. Peginterferon alfa-2b plus ribavirin for treatment of chronic hepatitis C in previously untreated patients infected with HCV genotype 2 or 3. J. Hepatol. 2004 40 : 993 999.
15. Liu CJ, Chuang WL, Lee CM et al. Peginterferon alfa-2a plus Ribavirin for the treatment of dual chronic infection with hepatitis B and C viruses. Gastroenterology 2009 136 : 496 504.
16. Chen SY, Kao CF, Chen CM et al. Mechanisms for inhibition of hepatitis B virus gene expression and replication by hepatitis C virus core protein. J. Biol. Chem. 2003 278 : 591 607.
17. Fabris P, Brown D, Tositti G et al. Occult hepatitis B virus infection does not affect liver histology or response to therapy with interferon alpha and ribavirin in intravenous drug users with chronic hepatitis C. J. Clin. Virol. 2004 29 : 160 166.
18. Hui CK, Lau E, Wu H et al. Fibrosis progression in chronic hepatitis C patients with occult hepatitis B co-infection. J. Clin. Virol. 2006 35 : 185 192.
19. Fukuda R, Ishimura N, Niigaki M et al. Serologically silent hepatitis B virus coinfection in patients with hepatitis C virus-associated chronic liver disease: clinical and virological significance. J. Med. Virol. 1999 58 : 201 207.