Mass spectrometry-based identification of Y745 of Vav1 as a tyrosine residue crucial in maturation of acute promyelocytic leukemia-derived cells

Journal of Proteome Research

Volumn 9, Issue 2, 2010, Pages 752-760

  Bertagnolo, Valeria ^a   Grassilli, Silvia ^a   D'Aguanno, Simona ^b,c   Brugnoli, Federica ^a   Bavelloni, Alberto ^d   Faenza, Irene ^e   Nika, Ervin ^a   Urbani, Andrea ^b,c   Cocco, Lucio ^e   Capitani, Silvano ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

^d RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^e UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Ganulocytic differentiation; Mass spectrometry; NB4 cells; Tyrosine phosphorylation; Vav1

Indexed keywords

CD11B ANTIGEN; MUTANT PROTEIN; PHENYLALANINE; PICEATANNOL; RETINOIC ACID; TYROSINE; UNCLASSIFIED DRUG; VAV PROTEIN; VAV1 PROTEIN;

AMINO ACID SUBSTITUTION; ANTIGEN EXPRESSION; ARTICLE; CANCER STEM CELL; CELL DIFFERENTIATION; CELL MATURATION; CELL MIGRATION; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MASS SPECTROMETRY; NEUTROPHIL; PHENOTYPE; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; UPREGULATION;

BASE SEQUENCE; CELL DIFFERENTIATION; CELL LINE, TUMOR; DNA PRIMERS; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; MASS SPECTROMETRY; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-VAV; TRETINOIN; TYROSINE;

EID: 76149094181     PISSN: 15353893     EISSN: None     Source Type: Journal    
DOI: 10.1021/pr900581y     Document Type: Article

References (28)

1. Mistry, A. R.; Pedersen, E. W.; Solomon, E.; Grimwade, D. The molecular pathogenesis of acute promyelocytic leukaemia: implications for the clinical management of the disease. Blood 2003, 17, 71-97.
2. Wojiski, S.; Guibal, F. C.; Kindler, T.; Lee, B. H.; Jesneck, J. L.; Fabian, A.; Tenen, D. G.; Gilliland, D. G. PML-RARalpha initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors. Leukemia 2009, 23, 1462-71.
3. Lo-Coco, F.; Ammatuna, E. The biology of acute promyelocytic leukemia and its impact on diagnosis and treatment. Hematol. Am. Soc. Hematol. Educ. Program 2006, 2006, 156-61.
4. Tallman, M. Treatment of relapsed or refractory acute promyelocytic leukemia. Best Pract. Res., Clin. Haematol. 2007, 20, 57-65.
5. Wang, Z. Y.; Chen, Z. Acute promyelocytic leukemia: from highly fatal to highly curable. Blood 2008, 111, 2505-15.
6. Breitman, T. R.; Selonick, S. E.; Collins, S. J. Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. Proc. Natl. Acad. Sci. U.S.A. 1980, 77, 2936-40.
7. Lanotte, M.; Martin-Thouvenin, V.; Najman, S.; Balerini, P.; Valensi, F.; Berger, R. NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3). Blood 1991, 77, 1080-6.
8. Lee, K. H.; Chang, M. Y.; Ahn, J. I.; Yu, D. H.; Jung, S. S.; Choi, J. H.; Noh, Y. H.; Lee, Y. S.; Ahn, M. J. Differential gene expression in retinoic acid-induced differentiation of acute promyelocytic leukemia cells, NB4 and HL-60 cells. Biochem. Biophys. Res. Commun. 2002, 296, 1125-33.
9. Katzav, S. Vav1: a hematopoietic signal transduction molecule involved in human malignancies. Int. J. Biochem. Cell Biol. 2009, 41, 1245-8.
10. Bertagnolo, V.; Brugnoli, F.; Marchisio, M.; Capitani, S. Inositidemodifying enzymes: a cooperative role in regulating nuclear morphology during differentiation of myeloid cells. J. Biol. Regul. Homeostatic Agents 2004, 18, 381-6.
11. Bertagnolo, V.; Brugnoli, F.; Mischiati, C.; Sereni, A.; Bavelloni, A.; Carini, C.; Capitani, S. Vav promotes differentiation of human tumoral myeloid precursors. Exp. Cell. Res. 2005, 306, 56-63.
12. Zhang, R.; Tsai, F. Y.; Orkin, S. H. Hematopoietic development of vav-/-mouse embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A. 1994, 91, 12755-9.
13. Bertagnolo, V.; Grassilli, S.; Bavelloni, A.; Brugnoli, F.; Piazzi, M.; Candiano, G.; Petretto, A.; Benedusi, M.; Capitani, S. Vav1 modulates protein expression during ATRA induced maturation of APL derived promyelocytes: a proteomic-based analysis. J. Proteome Res. 2008, 7, 3729-36.
14. Brugnoli, F; Lambertini, E; Varin-Blank, N; Piva, R; Marchisio, M; Grassilli, S; Miscia, S; Capitani, S; Bertagnolo, V. Vav1 and PU.1 are recruited to the CD11b promoter in APL-derived promyelocytes: role of Vav1 in modulating PU.1 containing complexes during ATRA induced differentiation. Exp. Cell Res. 2010, 316, 38-47.
15. Bustelo, X. R. Regulation of Vav proteins by intramolecular events. Front. Biosci. 2002, 7, d24-d30.
16. Tybulewicz, V. L. Vav-family proteins in T-cell signaling. Curr. Opin. Immunol. 2005, 17, 267-74.
17. Katzav, S. Flesh and blood: the story of Vav1, a gene that signals in hematopoietic cells but can be transforming in human malignancies. Cancer Lett. 2007, 255, 241-54.
18. Kuhne, M. R.; Ku, G.; Weiss, A. A guanine nucleotide exchange factor-independent. J. Biol. Chem. 2000, 275, 2185-90.
19. Zhao, T.; Benard, V.; Bohl, B. P.; Bokoch, G. M. The molecular basis for adhesion-mediated suppression of reactive oxygen species generation by human neutrophils. J. Clin. Invest. 2003, 104, 1732-40.
20. Gakidis, M. A.; Cullere, X.; Olson, T.; Wilsbacher, J. L.; Zhang, B.; Moores, S. L.; Ley, K.; Swat, W.; Mayadas, T.; Brugge, J. S. Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J. Cell. Biol. 2004, 166, 273-82.
21. Fumagalli, L.; Zhang, H.; Baruzzi, A.; Lowell, C. A.; Berton, G. The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl- leucyl-phenylalanine. J. Immunol. 2007, 178, 3874-85.
22. Schymeinsky, J.; Sindrilaru, A.; Frommhold, D.; Sperandio, M.; Gerstl, R.; Then, C.; Mócsai, A.; Scharffetter-Kochanek, K.; Walzog, B. The Vav binding site of the non-receptor tyrosine kinase Syk at Tyr 348 is critical for beta2 integrin (CD11/CD18)-mediated neutrophil migration. Blood 2006, 108, 3919-27.
23. Bertagnolo, V.; Marchisio, M.; Brugnoli, F.; Bavelloni, A.; Boccafogli, L.; Colamussi, M. L.; Capitani, S. Requirement of tyrosinephosphorylated Vav for morphological differentiation of all transretinoic acid-treated HL-60 cells. Cell Growth Differ. 2001, 12, 193-200.
24. Bertagnolo, V.; Brugnoli, F.; Marchisio, M.; Celeghini, C.; Carini, C.; Capitani, S. Association of PI3-K with tyrosine phosphorylated Vav is essential for its activity in neutrophil-like maturation of myeloid cells. Cell. Signalling 2004, 16, 423-33.
25. Bertagnolo, V.; Marchisio, M.; Volinia, S.; Caramelli, E.; Capitani, S. Nuclear association of tyrosine-phosphorylated Vav to phospholipase C-gamma1 and phosphoinositide 3-kinase during granulocytic differentiation of HL-60 cells. FEBS Lett. 1998, 441, 480-4.
26. Brugnoli, F.; Bavelloni, A.; Benedusi, M.; Capitani, S.; Bertagnolo, V. PLC-beta2 activity on actin-associated polyphosphoinositides promotes migration of differentiating tumoral myeloid precursors. Cell. Signalling 2007, 19, 1701-12.
27. Miletic, A. V.; Sakata-Sogawa, K.; Hiroshima, M.; Hamann, M. J.; Gomez, T. S.; Ota, N.; Kloeppel, T.; Kanagawa, O.; Tokunaga, M.; Billadeau, D. D.; Swat, W. Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation. J. Biol. Chem. 2006, 281, 38257-65.
28. Obenauer, J. C.; Cantley, L. C.; Yaffe, M. B. Scansite 2.0: Proteomewide prediction of cell signaling interactions using short sequence motifs. Nucleic Acids Res. 2003, 31, 3635-41.