Inflammatory biomarker profiling in elderly patients with acute hip fracture treated with heparins

Clinical and Applied Thrombosis/Hemostasis

Volumn 16, Issue 1, 2010, Pages 42-50

  Knesek, Michael John ^a   Litinas, Evangelos ^b   Adiguzel, Cafer ^b   Hopkinson, William ^b   Hoppensteadt, Debra ^b   Lassen, Michael ^c   Fareed, Jawed ^b  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^c Mental Health Services CPH   (Denmark)

Author keywords

Acute phase reactants; Biomarker; Hip fracture; Proteomics; Surface enhanced laser desorption ionization time of flight

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; ENOXAPARIN; HEPARIN; SERUM AMYLOID A; TISSUE FACTOR PATHWAY INHIBITOR; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HIGH RISK PATIENT; HIP FRACTURE; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MOLECULAR WEIGHT; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN MICROARRAY; RANDOMIZED CONTROLLED TRIAL; SURFACE ENHANCED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; TOTAL HIP PROSTHESIS; VENOUS THROMBOEMBOLISM;

ACUTE DISEASE; ACUTE-PHASE PROTEINS; AGED; AGED, 80 AND OVER; ANTICOAGULANTS; ARTHROPLASTY, REPLACEMENT, HIP; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; ENOXAPARIN; FEMALE; HIP FRACTURES; HUMANS; LIPOPROTEINS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; PROTEIN ARRAY ANALYSIS; PROTEOMICS; RISK FACTORS; SERUM AMYLOID A PROTEIN; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; THROMBOEMBOLISM; TUMOR NECROSIS FACTOR-ALPHA;

EID: 76049115544     PISSN: 10760296     EISSN: None     Source Type: Journal    
DOI: 10.1177/1076029609351876     Document Type: Article

References (14)

1. Cho, William. Identification of Serum Amyloid A Protein As a Potentially Useful Biomarker to Monitor Relapse of Nasopharyngeal Cancer by Serum Proteomic Profiling. Clinical Cancer Research 2004. 10: 43-52.
2. Fung ET, Thulasiraman V., Weinberger SR, et al. Protein biochips for differential profiling. Curr. Opin. Biotechnol., 12: 65-69, 2001.
3. Fung E., Enderwich C. ProteinChip clinical proteomics: computational challenges and solutions. Biotechniques, 32: S34 - S41, 2002.
4. Lassen M., Borris L., Breindahl M., et al. Thromboprophylaxis with Enoxaparin Versus Unfractionated Heparin in Elderly Patients with Acute Hip Fracture: Survival at Eight to Ten Years. Department of Orthopaedics Denmark.
5. Laronga C., Becker S., Watson P., et al. SELDI-TOF serum profiling for prognostic and diagnostic classification of breast cancers. Disease Markers 2003, 19: 229-238.
6. Li J., Zhang Z., Rosenzweig J., Wang YY, Chan DW: Proteomics and bioinformatics approaches for identification of serum biomarkers to detect breast cancer. Clinical Chemistry 2002, 48: 1296-1304.
7. Litinas E., Cagle P., Zhu He, et al. Identification of a unique plasma biomarker from patients undergoing total hip or knee replacement surgery utilizing protein chip array methods. FASEB 2008.
8. Miyamae, Takako, et al. Serum protein profile in systemic-onset juvenile idiopathic arthritis differentiates response versus nonresponse to therapy. Arthritis Research and Therapy. 2005. 7: 46-55.
9. Mozes G., et al. Serum amyloid A; an extremely sensitive marker for intensity of tissue damage in trauma patients and indicator of acute response in various diseases. The Journal of Trauma 1989. 1: 71-74.
10. Petricoin E., Zoon K., Kohn E., et al. Clinical Proteomics: Translating Benchside Promise Into Bedside Reality. Nature reviews. Drug Discovery 2002. 1: 683-695.
11. Tolson J., Bogumil R., Brunst E., et al,: Serum protein profiling by SELDI mass spectrometryL detection of multiple variants of serum amyloid alpha in renal cancer patients. Lab Invest 2004. 84: 845-856.
12. Urieli-Shoval S., Linke R., Matzner Y. Expression and function of serum amyloid A, a major acute-phase protein, in normal and disease states. Current Opinoin in Hematology 2000. 7: 64-69.
13. Wan, Susan et al. Thromboprophylaxis Practice Patterns in Hip Fracture Surgery Patients: Experience in Perth, Western Australia. ANZ J. Surgery 2003. 73: 826-829.
14. Wright, GL Jr. SELDI proteinchip MS: a platform for biomarker discovery and cancer diagnosis. Expert Review of Molecular Diagnositics 2002. 6: 549-563.