A fatal case of autumn crocus (colchicum autumnale) poisoning in a heifer: Confirmation by mass-spectrometric colchicine detection

Journal of Veterinary Diagnostic Investigation

Volumn 22, Issue 1, 2010, Pages 119-122

  Kupper, Jacqueline ^a,d   Rentsch, Katharina ^b   Mittelholzer, Andreas ^c   Artho, Romana ^c   Meyer, Sven ^c   Kupferschmidt, Hugo ^d   Naegeli, Hanspeter ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c Veterinary Practice   (Switzerland)

^d Schweizerisches Toxikologisches Informationszentrum   (Switzerland)

Author keywords

Autumn crocus; Cattle; Colchicine; Colchicum autumnale; Poisoning

Indexed keywords

BOS; COLCHICUM AUTUMNALE;

EID: 75949113908     PISSN: 10406387     EISSN: None     Source Type: Journal    
DOI: 10.1177/104063871002200125     Document Type: Article

References (23)

1. Baselt RC: 2004, Disposition of toxic drugs and chemicals in man, 7th ed. Biomedical Publications, Foster City, CA.
2. Baud FJ, Sabouraud A, Vicaut E, et al.; 1995, Treatment of severe colchicine overdose with colchicine-specific Fab frag-ments. N Engl J Med 332:642-655.
3. Bismuth C, Baud F, Dally S: 1986, Standardized prognosis evaluation in acute toxicology. Its benefit in colchicine, paraquat and digitalis poisonings. J Toxicol Clin Exp 6:33-38.
4. Caplan YH, Orloff KG, Thompson BC: 1980, A fatal overdose with colchicine. J Anal Toxicol 4:153-155.
5. Chèze M, Deveaux M, Pépin G: 2006, Liquid chromatography-tandem mass spectrometry for the determination of colchicine in postmortem body fluids. Case report of two fatalities and review of the literature. J Anal Toxicol 30: 593-598.
6. Cooper MR, Johnson AW, Dauncey EA: 2003, Poisonous plants and fungi, 2nd ed. TSO, London, UK.
7. Hamscher G, Priess B, Nau H, Panariti E: 2005, Determination of colchicine residues in sheep serum and milk using high-performance liquid chromatography combined with electro-spray ionization ion trap tandem mass spectrometry. Anal Chem 77:2424-2425.
8. Humphreys DJ: 1988, Veterinary toxicology, 3rd ed. Baillère Tindall, London, UK.
9. Kintz P, Jamey C, Tracqui A, Mangin P: 1997, Colchicine poisoning: report of a fatal case and presentation of an HPLC procedure for body fluid and tissue analyses. J Anal Toxicol 21:70-72.
10. Klintschar M, Beham-Schmidt C, Radner H, et al.; 1999, Colchicine poisoning by accidental ingestion of meadow saffron (Colchicum autumnale): pathological and medicolegal aspects. Forensic Sci Int 106:191-200.
11. Levy M, Spino M, Read SE: 1991, Colchicine: a state-of-the art review. Pharmacotherapy 11:196-211.
12. Lorgue G, Lechenet J, Rivière A: 1987, Précis de toxicology clinique vétérinaire [Clinical veterinary toxicology]. Le Point Vétérinaire, Maisons-Alfort, France. In French. English edition published 1996 by Blackwell Science, Oxford, UK.
13. Moffat AC, Osselton MD, Widdop B: 2004, Clarke's analysis of drugs and poisons, 3rd ed. Pharmaceutical Press, London, UK.
14. Ondra P, Valka I, Vicar J, et al.; 1995, Chromatographic determination of constituents of the genus Colchicum (Lilia-ceae). J Chromatogr A 704:351-356.
15. Panariti E: 1996, Meadow saffron (Colchicum autumnale) intoxication in a nomadic Albanian sheep flock. Vet Hum Toxicol 38:227-228.
16. Roberts LJ, Morrow JD: 2001, Analgesic-antipyretic and antiinflammatory agents and drugs employed in the treatment of gout. In: The pharmacologic basis of therapeutics, ed. Harman JG, Limbird LE, 10th ed., pp. 687-731. McGraw-Hill, New York, NY.
17. Rochdi M, Sabouraud A, Baud FJ, et al.; 1992, Toxicokinetics of colchicine in humans: analysis of tissue, plasma and urine data in ten cases. Hum Exp Toxicol 11:510-516.
18. Schulz M, Schmoldt A: 2003, Therapeutic and toxic blood concentrations of more than 800 drugs and other xenobiotics. Pharmazie 58:447-474.
19. Teuscher E, Lindequist U: 1994, Tropanalkaloide [Tropane alkaloid]. In: Biogene amine, 2nd ed., pp. 388-392. Gustav Fischer, Stuttgart, Germany. In German.
20. Tracqui A, Kintz P, Ludes B, et al.; 1996, High-performance liquid chromatography coupled to ion spray mass spec-trometry for the determination of colchicine at ppb levels in human biofluids. J Chromatogr B Biomed Appl 675:235-242.
21. Xu L, Adams B, Jeliazkova-Mecheva VV, et al.; 2008, Identification of novel metabolites of colchicine in rat bile facilitated by enhanced online radiometric detection. Drug Metab Dispos 36:731-739.
22. Yamada M, Nakagawa M, Haritani M, et al.; 1998, Histopathological study of experimental poisoning of cattle by autumn crocus (Colchicum autumnale L.). J Vet Med Sci 60:949-952.
23. Yoneda Y, Hayashi Y, Shiroishi M, Hayashi S: 1984, [High performance liquid chromatography determination of colchi-cine-alkaloid from the tissues and biological fluid of bovine poisoned by the corm of autumn crocus (Colchicum autumnale L.)]. J Food Hyg Soc Jpn 25:401-409. In Japanese. Abstract in English.