Gelsolin levels are increased in the brain as a function of age during normal development in children that are further increased in down syndrome

Alzheimer Disease and Associated Disorders

Volumn 23, Issue 4, 2009, Pages 319-322

  Ji, Lina ^a   Chauhan, Abha ^a   Muthaiyah, Balu ^a   Wegiel, Jerzy ^a   Chauhan, Ved ^a  

^a NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

Author keywords

Development; Down syndrome; Gelsolin; Oxidative stress

Indexed keywords

BETA ACTIN; CYSTEINE; GELSOLIN; MALONALDEHYDE; THIOBARBITURIC ACID;

ADOLESCENT; ARTICLE; CHILD; CHILD DEVELOPMENT; CONTROLLED STUDY; CYTOPLASM; DOWN SYNDROME; FEMALE; FRONTAL CORTEX; GELSOLIN TISSUE LEVEL; HUMAN; LIPID PEROXIDATION; MALE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; TISSUE LEVEL;

ADOLESCENT; AGING; ANTIOXIDANTS; BIOLOGICAL MARKERS; CHILD; CHILD, PRESCHOOL; DOWN SYNDROME; FEMALE; FRONTAL LOBE; GELSOLIN; HUMANS; INFANT; MALE; OXIDATIVE STRESS; UP-REGULATION;

EID: 75949104195     PISSN: 08930341     EISSN: None     Source Type: Journal    
DOI: 10.1097/WAD.0b013e31819d494e     Document Type: Article

References (25)

1. Epstein CJ. The Metabolic and Molecular Basis of Inherited Disease. 7th ed. Vol 1. New York, NY: McGraw Hill Inc; 1995:749-794.
2. Lott IT, Head E, Doran E, et al. Beta-amyloid, oxidative stress and Down syndrome. Curr Alzheimer Res. 2006;3:521-528.
3. Chauhan V, Chauhan A. Oxidative stress in Alzheimer's disease. Pathophysiology. 2006;13:195-208.
4. Korenberg JR, Kawashima H, Pulst SM, et al. Molecular definition of a region of chromosome 21 that causes features of the Down syndrome phenotype. Am J Hum Genet. 1990;47: 236-246.
5. Schuchmann S, Heinemann U. Increased mitochondrial superoxide generation in neurons from trisomy 16 mice: a model of Down's syndrome. Free Radic Biol Med. 2000;28:235-250.
6. Ji L, Chauhan A, Chauhan V. Cytoplasmic gelsolin in pheochromocytoma-12 cells forms a complex with amyloid beta-protein. Neuroreport. 2008;19:463-466.
7. Stossel TP. Actin-membrane interactions in eukaryotic mammalian cells. In: Hoffman JF, Giebisch G, eds. Current Topics in Membranes and Transport. San Diego, CA: Academic Press; 1990:97-107.
8. Kwiatkowski DJ, Mehl R, Yin HL. Genomic organization and biosynthesis of secreted and cytoplasmic forms of gelsolin. J Cell Biol. 1988;106:375-384.
9. Wen D, Corina K, Chow EP, et al. The plasma and cytoplasmic forms of human gelsolin differ in disulfide structure. Biochemistry. 1996;35:9700-9709.
10. Kothakota S, Azuma T, Reinhard C, et al. Caspase- 3-generated fragment of gelsolin: effector of morphological change in apoptosis. Science. 1997;278:294-298.
11. Kusano H, Shimizu S, Koya RC, et al. Human gelsolin prevents apoptosis by inhibiting apoptotic mitochondrial changes via closing VDAC. Oncogene. 2000;19:4807-4814.
12. Chauhan V, Ji L, Chauhan A. Anti-amyloidogenic, antioxidant and anti-apoptotic role of gelsolin in Alzheimer's disease. Biogerontology. 2008;9:381-389.
13. Chauhan VPS, Ray I, Chauhan A, et al. Binding of gelsolin, a secretory protein to amyloid b-protein. Biochem Biophys Res Commun. 1999;258:241-246.
14. Ray I, Chauhan A, Wegiel J, et al. Gelsolin inhibits the fibrillization of amyloid beta-protein, and also defibrillizes its preformed fibrils. Brain Res. 2000;853:344-351.
15. Matsuoka Y, Saito M, LaFrancois J, et al. Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to betaamyloid. J Neurosci. 2003;23:29-33.
16. Hirko AC, Meyer EM, King MA, et al. Peripheral transgene expression of plasma gelsolin reduces amyloid in transgenic mouse models of Alzheimer's disease. Mol Ther. 2007;5: 1623-1629.
17. Chauhan A, Chauhan V, Brown WT, et al. Oxidative stress in autism: increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin-the antioxidant proteins. Life Sci. 2004;75:2539-2549.
18. Juurlink BH, Paterson PG. Review of oxidative stress in brain and spinal cord injury: suggestions for pharmacological and nutritional management strategies. J Spinal Cord Med. 1998; 21:309-334.
19. Ono H, Sakamoto A, Sakura N. Plasma total glutathione concentrations in healthy pediatric and adult subjects. Clin Chim Acta. 2001;312:227-229.
20. Perrone S, Longini M, Bellieni CV, et al. Early oxidative stress in amniotic fluid of pregnancies with Down syndrome. Clin Biochem. 2007;40:177-180.
21. Basu D, Le J, Zakharova T, et al. A SPIKE1 signaling complex controls actin-dependent cell morphogenesis through the heteromeric WAVE and ARP2/3 complexes. Proc Natl Acad Sci USA. 2008;105:4044-4049.
22. Harman D. Free radical theory of aging. Triangle. 1973;12: 153-158.
23. Davies MJ. The oxidative environment and protein damage. Biochim Biophys Acta. 2005;1703:93-109.
24. Baty JW, Hampton MB, Winterbourn CC. Detection of oxidant sensitive thiol proteins by fluorescence labeling and two-dimensional electrophoresis. Proteomics. 2002;2: 1261-1266.
25. McDonagh B, Sheehan D. Effect of oxidative stress on protein thiols in the blue mussel Mytilus edulis: proteomic identification of target proteins. Proteomics. 2007;7: 3395-3403.