Effect of recombinant human transforming growth factor-β2 dose on bone formation in rat femur titanium implant model

Journal of Biomedical Materials Research - Part A

Volumn 92, Issue 3, 2010, Pages 1210-1217

  Sena, Kotaro ^a   Sumner, Dale R ^a   Virdi, Amarjit S ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Animal model; Bone healing; Image analysis mechanical test; Joint replacement; TGF (transforming growth factor)

Indexed keywords

ANIMAL MODEL; BONE HEALING; JOINT REPLACEMENT; MECHANICAL TESTS; TGF (TRANSFORMING GROWTH FACTOR);

ANIMALS; BIOACTIVITY; COMPUTERIZED TOMOGRAPHY; IMAGE ANALYSIS; JOINT PROSTHESES; PEPTIDES; TITANIUM;

BONE;

CALCIUM PHOSPHATE; HYDROXYAPATITE; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA2; TITANIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEMUR; IMPLANT; IMPLANTATION; MATERIAL COATING; NONHUMAN; OSSIFICATION; RAT;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMUR; PROSTHESES AND IMPLANTS; RATS; RECOMBINANT PROTEINS; TITANIUM; TRANSFORMING GROWTH FACTOR BETA;

EID: 75749153662     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.32461     Document Type: Article

References (37)

1. DeFrances CJ, Hall MJ. 2005 National Hospital Discharge Survey. Adv Data 2007;385:1-19.
2. Bauer TW, Schils J. The pathology of total joint arthroplasty. I. Mechanisms of implant fixation. Skeletal Radiol 1999;28: 423-432.
3. Ryd L, Albrektsson BE, Carlsson L, Dansgard F, Herberts P, Lindstrand A, Regner L, Toksvig-Larsen S. Roentgen stereophotogrammetric analysis as a predictor of mechanical loosening of knee prostheses. J Bone Joint Surg 1995;77:377-383.
4. Sumner DR, Turner TM, Purchio AF, Gombotz WR, Urban RM, Galante JO. Enhancement of bone ingrowth by transforming growth factor βeta. J Bone Joint Surg A 1995;77:1135-1147.
5. Zhou H, Choong PC, Chou ST, Kartsogiannis V, Martin TJ, Ng KW. Transforming growth factor β1 stimulates bone formation and resorption in an in-vivo model in rabbits. Bone 1995;17:443S-448S.
6. Lind M, Overgaard S, Søballe K, Nguyen T, Ongpipattanakul B, Bü nger C. Transforming growth factor-b1 enhances bone healing to unloaded tricalcium phosphate coated implants: An experimental study in dogs. J Orthop Res 1996;14:343-350.
7. Lind M, Overgaard S, Nguyen T, Ongpipattanakul B, Bü nger C, Søballe K. Transforming growth factor-b stimulates bone ongrowth: Hydroxyapatite-coated implants studied in dogs. Acta Orthop Scand 1996;67:611-616.
8. Lind M, Overgaard S, Ongpipattanakul B, Nguyen T, Bü nger C, Søballe K. Transforming growth factor-beta 1 stimulates bone ongrowth to weight-loaded tricalcium phosphate coated implants: An experimental study in dogs. J Bone Joint Surg 1996;78:377-382.
9. Lind M, Overgaard S, Glerup H, Soballe K, Bunger C. Transforming growth factor-beta1 adsorbed to tricalciumphosphate coated implants increases peri-implant bone remodeling. Biomaterials 2001;22:189-193.
10. Clarke SA, Brooks RA, Lee PT, Rushton N. The effect of osteogenic growth factors on bone growth into a ceramic filled defect around an implant. J Orthop Res 2004;22:1016-1024.
11. Sumner DR, Turner TM, Urban RM, Leven RM, Hawkins M, Nichols EH, McPherson JM, Galante JO. Locally delivered rhTGF-β2 enhances bone ingrowth and bone regeneration at local and remote sites of skeletal injury. J Orthop Res 2001;19: 85-94.
12. Sumner DR, Turner TM, Cohen M, Losavio P, Urban RM, Nichols EH, McPherson JM. Aging does not lessen the effectiveness of TGF-ß2 enhanced bone regeneration. J Bone Miner Res 2003;18:730-736.
13. De Ranieri A, Virdi AS, Kuroda S, Shott S, Leven RM, Hallab NJ, Sumner DR. Local application of rhTGF-β2 enhances peri-implant bone volume and bone-implant contact in a rat model. Bone 2005;37:55-62.
14. Hu PP, Datto MB, Wang XF. Molecular mechanisms of transforming growth factor-beta signaling. Endocr Rev 1998;19: 349-363.
15. Qin X, Gysin R, Mohan S, Baylink JD. Bone growth factors. In: Marcus R, Feldman D, Kelsey J, editors. Osteoporosis. San Diego: Academic Press; 2001. p 405-431.
16. Moioli EK, Clark PA, Sumner DR, Mao JJ. Autologous stem cell regeneration in craniosynostosis. Bone 2008;42:332-340.
17. Joyce ME, Roberts AB, Sporn MB, Bolander ME. Transforming growth factor-b and the initiation of chondrogenesis and osteogenesis in the rat femur. J Cell Biol 1990;110:2195-2207.
18. Noda M, Camilliere JJ. In vivo stimulation of bone formation by transforming growth factor-b. Endocrinology 1989;124: 2991-2994.
19. Marcelli C, Yates AJ, Mundy GR. In vivo effects of human recombinant transforming growth factor β on bone turnover in normal mice. J Bone Miner Res 1990;5:1087-1096.
20. Fujimoto R, Tanizawa T, Nishida S, Yamamoto N, Soshi S, Endo N, Takahashi HE. Local effects of transforming growth factor-beta1 on rat calvaria: Changes depending on the dose and the injection site. J Bone Miner Metab 1999;17:11-17.
21. Rosen D, Miller SC, DeLeon E, Thompson AY, Bentz H, Mathews M, Adams S. Systemic administration of recombinant transforming growth factor βeta 2 (rTGF-β2) stimulates parameters of cancellous bone formation in juvenile and adult rats. Bone 1994;15:355-359.
22. Janssens K, ten Dijke P, Janssens S, Van Hul W. Transforming growth factor-beta1 to the bone. Endocr Rev 2005;26:743-774.
23. Kuroda S, Virdi AS, Li P, Healy KE, Sumner DR. A low temperature biomimetic calcium phosphate surface enhances early implant fixation in a rat model. J Biomed Mater Res A 2004;70:66-73.
24. De Ranieri A, Virdi AS, Kuroda S, Shott S, Dai Y, Sumner DR. Local application of rhTGF-β2 modulates dynamic gene expression in a rat implant model. Bone 2005;36:931-940.
25. De Ranieri A, Virdi AS, Kuroda S, Healy KE, Sumner DR. Saline irrigation does not affect bone formation or implant fixation strength in a rat model. J Biomed Mater Res Part B: Appl Biomater 2005;74:712-717.
26. Pfeilschifter J, Wolf O, Naumann A, Minne HW, Mundy GR, Ziegler R. Chemotactic response of osteoblastlike cells to transforming growth factor βeta. J Bone Miner Res 1990;5: 825-830.
27. Hock JM, Canalis E, Centrella M. Transforming growth factor-b stimulates bone matrix apposition and bone cell replication in cultured fetal rat calvariae. Endocrinology 1990;126: 421-426.
28. Harris SE, Bonewald LF, Harris MA, Sabatini M, Dallas S, Feng JQ, Ghosh-Choudhury N, Wozney J, Mundy GR. Effects of transforming growth factor β on bone nodule formation and expression of bone morphogenetic protein 2, osteocalcin, osteopontin, alkaline phosphatase, and Type I collagen mRNA in long-term cultures of fetal rat calvarial osteoblasts. J Bone Miner Res 1994;9:855-863.
29. Antosz ME, Bellows CG, Aubin JE. Effects of transforming growth factor βeta and epidermal growth factor on cell proliferation and the formation of bone nodules in isolated fetal rat calvaria cells. J Cell Physiol 1989;140:386-395.
30. Chen TL, Bates RL. Recombinant human transforming growth factor β1 modulates bone remodeling in a mineralizing bone organ culture. J Bone Miner Res 1993;8:423-434.
31. Mundy GR, Oyajobi B, Traianedes K, Dallas S, Chen D. Cytokines and bone remodeling. In: Marcus R, Feldman D, Kelsey J, editors. Osteoporosis. San Diego: Academic Press; 2001. p 373-403.
32. Erlebacher A, Derynck R. Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype. J Cell Biol 1996;132:195-210.
33. Broderick E, Infanger S, Turner TM, Sumner DR. Depressed bone mineralization following high dose TGF-beta1 application in an orthopedic implant model. Calcif Tissue Int 2005; 76:379-384.
34. Balooch G, Balooch M, Nalla RK, Schilling S, Filvaroff EH, Marshall GW, Marshall SJ, Ritchie RO, Derynck R, Alliston T. TGF-beta regulates the mechanical properties and composition of bone matrix. Proc Natl Acad Sci USA 2005;102:18813-18818.
35. Patt HM, Maloney MA. Bone marrow regeneration after local injury: A review. Exp Hemat 1975;3:135-148.
36. Sumner DR, Turner TM, Urban RM, Virdi AS, Inoue N. Additive enhancement of implant fixation following combined treatment with rhTGF-β2 and rhBMP-2 in a canine model. J Bone Joint Surg (Am) 2006;88:806-817.
37. Soballe K, Jensen TB, Mouzin O, Kidder L, Bechtold JE. Differential effect of a bone morphogenetic protein-7 (OP-1) on primary and revision loaded, stable implants with allograft. J Biomed Mater Res A 2004;71:569-576.