C2- and C4-position 17β-estradiol metabolites and their relation to breast cancer

Biocell

Volumn 33, Issue 3, 2009, Pages 137-140

  Joubert, Annie ^a   Van Zyl, Hermia ^a   Laurens, Johannes ^a   Lottering, Mona Liza ^a  

^a UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

2 methoxyestradiol; Breast cancer; Estradiol metabolism

Indexed keywords

2 HYDROXYESTRADIOL; 2 METHOXYESTRADIOL; 4 HYDROXYESTRADIOL; ESTRADIOL; ESTROGEN RECEPTOR; 2-HYDROXYESTRADIOL; 2-METHOXYESTRADIOL; 4 HYDROXYESTRADIOL 17 BETA; 4-HYDROXYESTRADIOL-17 BETA; DRUG DERIVATIVE;

APOPTOSIS; BREAST CANCER; BREAST CARCINOGENESIS; CELL TRANSFORMATION; HORMONE ACTION; HUMAN; METABOLITE; SHORT SURVEY; TUMOR GROWTH; ANIMAL; BREAST TUMOR; CELL PROLIFERATION; METABOLISM; REVIEW;

ANIMALS; BREAST NEOPLASMS; CELL PROLIFERATION; ESTRADIOL; HUMANS;

EID: 75749150930     PISSN: 03279545     EISSN: 16675746     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (23)

1. Adams JB (1998). Adrenal androgens and human breast cancer: a new appraisal. Breast Cancer Research Treatment 51: 183-188.
2. Bishop DT (1999). BRCA1 and BRCA2 and breast cancer incidence: a review. Annals of Oncology 10 Suppl 6: 113-119.
3. Cavalieri E, Frenkel K, Liehr JG, Rogan E, Roy D (2000). Estrogens as endogenous genotoxic agents - DNA adducts and mutations. Jornal of the National Cancer Institute Monographs 27: 75-93.
4. Chodosh LA, D'Cruz CM, Gardner HP, Ha SI, Marquis ST, Rajan JV, Stairs DB, Wang JY, Wang M (1999). Mammary gland development, reproductive history, and breast cancer risk. Cancer Research 59: 1765-1771s.
5. Clemons M, Goss P (2001). Estrogen and the risk of breast cancer. New England Journal of Medicine 344: 276-285.
6. D'Amato RJ, Lin CM, Flynn E, Folkman J, Hamel E (1994). 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site. Proceedings of the National Academy of Sciences of the United States of America 91: 3964-3968.
7. Duncan JA, Reeves JR, Cooke TG (1998). BRCA1 and BRCA2 proteins: roles in health and disease. Molecular Patholology 51: 237-247.
8. Henderson BE, Feigelson HS (2000). Hormonal carcinogenesis. Carcinogenesis 21: 427-433.
9. Hofmann W, Schlag PM (2000). BRCA1 and BRCA2-breast cancer susceptibility genes. Journal of Cancer Research and Clinical Oncology 126: 487-496.
10. Jefcoate CR, Liehr JG, Santen RJ, Sutter TR, Yager JD, Yue W, Santner SJ, Tekmal R, Demers L, Pauley R, Naftolin F, Mor G, Berstein L (2000). Tissue-specific synthesis and oxidative metabolism of estrogens. Journal of the National Cancer Institute Monographs 27: 95-112.
11. LaVallee TM, Burke PA, Swartz GM, Hamel E, Agoston GE, Shah J, Suwandi L, Hanson AD, Fogler WE, Sidor CF, Treston AM (2008). Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198. Molecular Cancer Therapy 7: 1472-1482.
12. Lemon HM, Heidel JW, Rodriguez-Sierra JF (1992). Increased catechol estrogen metabolism as a risk factor for nonfamilial breast cancer. Cancer 69: 457-465.
13. Liehr JG, Ricci MJ (1996). 4-Hydroxylation of estrogens as marker of human mammary tumors. Proceedings of the National Academy of Sciences of the United States of America 93: 3294-3296.
14. Lottering ML, Haag M, Seegers JC (1992). Effects of 17 beta-estradiol metabolites on cell cycle events in MCF-7 cells. Cancer Research 52: 5926-5932.
15. Mabjeesh NJ, Escuin D, LaVallee TM, Pribluda VS, Swartz GM, Johnson MS, Willard MT, Zhong H, Simons JW, Giannakakou P (2003). 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell 3: 363-375.
16. Parl FF, Dawling S, Roodi N, Crooke PS (2009). Estrogen metabolism and breast cancer: a risk model. Annals of the New York Academy of Sciences 1155: 68-75.
17. Pathak DR, Osuch JR, He J (2000). Breast carcinoma etiology: current knowledge and new insights into the effects of reproductive and hormonal risk factors in black and white populations. Cancer 88: 1230-1238.
18. Russo J, Hu YF, Yang X, Russo IH (2000). Developmental, cellular, and molecular basis of human breast cancer. Journal of the National Cancer Institute Monographs 27: 17-37.
19. Russo J, Russo IH (2006). The role of estrogen in the initiation of breast cancer. Journal of Steroid Biochemistry and Molecular Biology 102: 89-96.
20. Santen R, Cavalieri E, Rogan E, Russo J, Guttenplan J, Ingle J, Yue W (2009). Estrogen mediation of breast tumor formation involves estrogen receptor-dependent, as well as independent, genotoxic effects. Annals of the New York Academy of Sciences 1155: 132-140.
21. Schultz LB, Weber BL (1999). Recent advances in breast cancer biology. Current Opinion in Oncology 11: 429-434.
22. Zhu BT, Conney AH (1998a). Functional role of estrogen metabolism in target cells: review and perspectives. Carcinogenesis 19: 1-27.
23. Zhu BT, Conney AH (1998b). Is 2-methoxyestradiol an endogenous estrogen metabolite that inhibits mammary carcinogenesis? Cancer Research 58: 2269-2277.