A paramagnetic implant containing lithium naphthalocyanine microcrystals for high-resolution biological oximetry

Journal of Magnetic Resonance

Volumn 203, Issue 1, 2010, Pages 185-189

  Meenakshisundaram, Guruguhan ^a   Pandian, Ramasamy P ^a   Eteshola, Edward ^a   Lee, Stephen C ^a   Kuppusamy, Periannan ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Biocompatible EPR probe; High sensitivity probe; Oxygen sensor; Polymer coating

Indexed keywords

BIOCOMPATIBLE EPR PROBE; BIOINERT; DIRECT CONTACT; EPR OXIMETRY; EPR SIGNALS; FABRICATED CHIPS; HIGH RESOLUTION; HIGH-SENSITIVITY; HIGH-SENSITIVITY PROBE; IN-VIVO; MOLECULAR PACKINGS; NAPHTHALOCYANINES; OXIMETRY; OXYGEN MEASUREMENTS; OXYGEN SENSITIVITY; PARTICLE MIGRATION; POLYMER COATING; POTENTIAL PROBES; REPEATED MEASUREMENTS; TISSUE OXYGENATION; WOODWARD;

CATALYST ACTIVITY; CRYSTALS; ELECTRON RESONANCE; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENCAPSULATION; LITHIUM; MAGNETIC PROPERTIES; MICROCHANNELS; MICROCRYSTALS; OXYGEN SENSORS; OXYGENATION; OXYGENATORS; PARAMAGNETIC MATERIALS; PARAMAGNETIC RESONANCE; PLASTIC COATINGS; PROBES; PUMPS; QUANTUM THEORY; SENSORS; SILICONES;

MOLECULAR OXYGEN;

BAYSILON; BIOMATERIAL; DIMETICONE; LITHIUM OCTA N BUTOXYNAPHTHALOCYANINE; LITHIUM OCTA-N-BUTOXYNAPHTHALOCYANINE; PORPHYRIN;

ANIMAL; ARTICLE; C3H MOUSE; CALIBRATION; CHEMISTRY; CRYSTALLIZATION; DRUG FORMULATION; ELECTRODE; ELECTRON SPIN RESONANCE; FEMALE; INSTRUMENT STERILIZATION; INSTRUMENTATION; METABOLISM; MICROCOMPUTER; MOUSE; OXIDATION REDUCTION REACTION; OXIMETRY; SKELETAL MUSCLE;

ANIMALS; BIOCOMPATIBLE MATERIALS; CALIBRATION; CRYSTALLIZATION; DIMETHYLPOLYSILOXANES; DRUG COMPOUNDING; ELECTRODES, IMPLANTED; ELECTRON SPIN RESONANCE SPECTROSCOPY; FEMALE; MICE; MICE, INBRED C3H; MICROCOMPUTERS; MUSCLE, SKELETAL; OXIDATION-REDUCTION; OXIMETRY; PORPHYRINS; STERILIZATION;

EID: 75749147527     PISSN: 10907807     EISSN: 10960856     Source Type: Journal    
DOI: 10.1016/j.jmr.2009.11.016     Document Type: Article

References (23)

1. 2 measurements by electron paramagnetic resonance oximetry: current status and future potential for experimental and clinical studies. Antioxid. Redox. Signal. 9 (2007) 1169-1182
2. Swartz H.M. Using EPR to measure a critical but often unmeasured component of oxidative damage: oxygen. Antioxid. Redox. Signal. 6 (2004) 677-686
3. Hopf H.W., and Rollins M.D. Wounds: an overview of the role of oxygen. Antioxid. Redox. Signal. 9 (2007) 1183-1192
4. Kulkarni A.C., Kuppusamy P., and Parinandi N. Oxygen, the lead actor in the pathophysiologic drama: enactment of the trinity of normoxia, hypoxia, and hyperoxia in disease and therapy. Antioxid. Redox. Signal. 9 (2007) 1717-1730
5. Kutala V.K., Khan M., Angelos M.G., and Kuppusamy P. Role of oxygen in postischemic myocardial injury. Antioxid. Redox. Signal. 9 (2007) 1193-1206
6. Marso S.P., and Hiatt W.R. Peripheral arterial disease in patients with diabetes. J. Am. Coll. Cardiol. 47 (2006) 921-929
7. Vaupel P., Hockel M., and Mayer A. Detection and characterization of tumor hypoxia using pO2 histography. Antioxid. Redox. Signal. 9 (2007) 1221-1235
8. Pandian R.P., Dolgos M., Marginean C., Woodward P.M., Hammel P.C., Manoharan P.T., and Kuppusamy P. Molecular packing and magnetic properties of lithium naphthalocyanine crystal: hollow channels enabling permeability and paramagnetic sensitivity to molecular oxygen. J. Mater. Chem. 19 (2009) 4138-4147
9. Ilangovan G., Zweier J., and Kuppusamy P. Electrochemical preparation and EPR studies of lithium phthalocyanine. Part 2: particle-size-dependent line broadening by molecular oxygen and its implications as an oximetry probe. J. Phys. Chem. B 104 (2000) 9404-9410
10. Liu K.J., Gast P., Moussavi M., Norby S.W., Vahidi N., Walczak T., Wu M., and Swartz H.M. Lithium phthalocyanine - a probe for electron-paramagnetic-resonance oximetry in viable biological-systems. Proc. Natl. Acad. Sci. USA 90 (1993) 5438-5442
11. Pandian R.P., Parinandi N.L., Ilangovan G., Zweier J.L., and Kuppusamy P. Novel particulate spin probe for targeted determination of oxygen in cells and tissues. Free Radic. Biol. Med. 35 (2003) 1138-1148
12. Dinguizli A., Jeumont S., Beghein N., He J., Walczak T., Lesniewski P.N., Hou H., Grinberg O.Y., Sucheta A., Swartz H.M., and Gallez B. Development and evaluation of biocompatible films of polytetrafluoroethylene polymers holding lithium phthalocyanine crystals for their use in EPR oximetry. Biosens. Bioelectron. 21 (2006) 1015-1022
13. Eteshola E., Pandian R.P., Lee S.C., and Kuppusamy P. Polymer coating of paramagnetic particulates for in vivo oxygen-sensing applications. Biomed. Microdevices 11 (2009) 379-387
14. 2 in vivo using low frequency EPR spectroscopy: how to confer biocompatibility to the oxygen sensors. Free Radic. Biol. Med. 29 (2000) 1078-1084
15. Meenakshisundaram G., Eteshola E., Pandian R.P., Bratasz A., Lee S.C., and Kuppusamy P. Fabrication and physical evaluation of a polymer-encapsulated paramagnetic probe for biomedical oximetry. Biomed. Microdevices 11 (2009) 773-782
16. Meenakshisundaram G., Eteshola E., Pandian R.P., Bratasz A., Selvendiran K., Lee S.C., Krishna M.C., Swartz H.M., and Kuppusamy P. Oxygen sensitivity and biocompatibility of an implantable paramagnetic probe for repeated measurements of tissue oxygenation. Biomed. Microdevices 11 (2009) 817-826
17. Abbasi F., Mirzadeh H., and Katbab A.A. Modification of polysiloxane polymers for biomedical applications: a review. Polym. Int. 50 (2001) 1279-1287
18. Mata A., Fleischman A.J., and Roy S. Characterization of polydimethylsiloxane (PDMS) properties for biomedical micro/nanosystems. Biomed. Microdevices 7 (2005) 281-293
19. Kutala V.K., Parinandi N.L., Pandian R.P., and Kuppusamy P. Simultaneous measurement of oxygenation in intracellular and extracellular compartments of lung microvascular endothelial cells. Antioxid. Redox. Signal. 6 (2004) 597-603
20. Bratasz A., Pandian R.P., Deng Y., Petryakov S., Grecula J.C., Gupta N., and Kuppusamy P. In vivo imaging of changes in tumor oxygenation during growth and after treatment. Magn. Reson. Med. 57 (2007) 950-959
21. Dvornic P.R. Thermal properties of polysiloxanes at low temperatures. In: Jones R.G., Ando W., and Chojnowski J. (Eds). Silicon-containing Polymers - The Science and Technology of their Synthesis and Applications (2000), Kluwer Academic Publishers, Norwell, MA 185-212
22. Ilangovan G., Bratasz A., Li H., Schmalbrock P., Zweier J.L., and Kuppusamy P. In vivo measurement and imaging of tumor oxygenation using coembedded paramagnetic particulates. Magn. Reson. Med. 52 (2004) 650-657
23. Ilangovan G., Manivannan A., Li H.Q., Yanagi H., Zweier J.L., and Kuppusamy P. A naphthalocyanine-based EPR probe for localized measurements of tissue oxygenation. Free Radic. Biol. Med. 32 (2002) 139-147