Placental site trophoblastic tumor: lymphatic spread and possible target markers

Gynecologic Oncology

Volumn 116, Issue 3, 2010, Pages 430-437

  Lan, Chunyan ^a   Li, Yanfang ^a   He, Jiehua ^a   Liu, Jihong ^a  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

Author keywords

Lymphadenectomy; Lymphatic spread; Metastasis; Placental site trophoblastic tumor; Targeted therapy

Indexed keywords

CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; DACTINOMYCIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIRUBICIN; ETOPOSIDE; FLOXURIDINE; FLUOROURACIL; IFOSFAMIDE; METHOTREXATE; OXALIPLATIN; STEM CELL FACTOR RECEPTOR; TUMOR MARKER; VASCULOTROPIN;

ADULT; ARTICLE; CANCER CHEMOTHERAPY; CANCER RECURRENCE; CANCER RELAPSE; CANCER SURVIVAL; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH FLOW; LYMPH NODE METASTASIS; MEDLINE; ONCOGENE NEU; OVARY METASTASIS; PARAAORTIC LYMPH NODE; PATIENT IDENTIFICATION; PELVIS CANCER; POSTMENOPAUSE; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETROPERITONEAL CANCER; RETROSPECTIVE STUDY; TROPHOBLASTIC TUMOR;

ADULT; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPH NODES; LYMPHATIC METASTASIS; MIDDLE AGED; PREGNANCY; PROTO-ONCOGENE PROTEINS C-KIT; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; TROPHOBLASTIC TUMOR, PLACENTAL SITE; UTERINE NEOPLASMS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 75749140469     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2009.10.056     Document Type: Article

References (57)

1. Ajithkumar T.V., Abraham E.K., Rejnishkumar R., and Minimole A.L. Placental site trophoblastic tumor. Obstet. Gynecol. Surv. 58 (2003) 484-488
2. Kurman R.J., Scully R.E., and Norris H.J. Trophoblastic pseudotumor of the uterus: an exaggerated form of "syncytial endometritis" simulating a malignant tumor. Cancer 38 (1976) 1214-1226
3. Twiggs L.B., Okagaki T., Phillips G.L., Stroemer J.R., and Adcock L.L. Trophoblastic pseudotumor-evidence of malignant disease potential. Gynecol. Oncol. 12 2 Pt 1 (1981) 238-248
4. Scully R.E., and Young R.H. Trophoblastic pseudotumor: a reappraisal. Am. J. Surg. Patho. 5 (1981) 75-76
5. Chang Y.L., Chang T.C., Hsueh S., Huang K.G., Wang P.N., Liu H.P., et al. Prognostic factors and treatment for placental site trophoblastic tumor-report of 3 cases and analysis of 88 cases. Gynecol. Oncol. 73 (1999) 216-222
6. Hassadia A., Gillespie A., Tidy J., Everard R.G.N.J., Wells M., Coleman R., et al. Placental site trophoblastic tumour: clinical features and management. Gynecol. Oncol. 99 (2005) 603-607
7. Baergen R.N., Rutgers J.L., Young R.H., Osann K., and Scully R.E. Placental site trophoblastic tumor: A study of 55 cases and review of the literature emphasizing factors of prognostic significance. Gynecol. Oncol. 100 (2006) 511-520
8. Feltmate C.M., Genest D.R., Wise L., Bernstein M.R., Goldstein D.P., and Berkowitz R. Placental site trophoblastic tumor: a 17-year experience at the New England Trophoblastic Disease Center. Gynecol. Oncol. 82 (2001) 415-419
9. Papadopoulos A.J., Foskett M., Seckl M.J., McNeish I., Paradinas F.J., Rees H., and Newlands E.S. Twenty-five years' clinical experience with placental site trophoblastic tumors. J. Reprod. Med. 47 (2002) 460-464
10. Gloor E., and Hürlimann J. Trophoblastic pseudotumor of the uterus: clinicopathologic report with immunohistochemical and ultrastructural studies. Am. J. Surg. Pathol. 5 (1981) 5-13
11. Gloor E., Dialdas J., Hurlimann J., Ribolzi J., and Barrelet L. Placental site trophoblastic tumor (trophoblastic pseudotumor) of the uterus with metastases and fatal outcome. Clinical and autopsy observations of a case. Am. J. Surg. Pathol. 7 (1983) 483-486
12. Eckstein R.P., Russell P., Friedlander M.L., Tattersall M.H., and Bradfield A. Metastasizing placental site trophoblastic tumor: a case study. Hum. Pathol. 16 (1985) 632-636
13. Finkler N.J., Berkowitz R.S., Driscoll S.G., Goldstein D.P., and Bernstein M.R. Clinical experience with placental site trophoblastic tumors at the New England Trophoblastic Disease Center. Obstet. Gynecol. 71 6 Pt 1 (1988) 854-857
14. Fukunaga M., and Ushigome S. Malignant trophoblastic tumors: immunohistochemical and flow cytometric comparison of choriocarcinoma and placental site trophoblastic tumors. Hum. Pathol. 24 (1993) 1098-1106
15. Hoffman J.S., Silverman A.D., Gelber J., and Cartun R. Placental site trophoblastic tumor: a report of radiologic, surgical, and pathologic methods of evaluating the extent of disease. Gynecol. Oncol. 50 (1993) 110-114
16. Bower M., Paradinas F.J., Fisher R.A., Nicholson S.K., Rustin G.J., Begent R.H., et al. Placental site trophoblastic tumor: molecular analysis and clinical experience. Clin. Cancer. Res. 2 (1996) 897-902
17. Newlands E.S., Bower M., Fisher R.A., and Paradinas F.J. Management of placental site trophoblastic tumors. J. Reprod. Med. 43 (1998) 53-59
18. Rinne K., Shahabi S., and Cole L. Following metastatic placental site trophoblastic tumor with urine beta-core fragment. Gynecol. Oncol. 74 (1999) 302-303
19. Hoekstra A.V., Keh P., and Lurain J.R. Placental site trophoblastic tumor: a review of 7 cases and their implications for prognosis and treatment. J. Reprod. Med. 49 (2004) 447-452
20. Metindir J., Pak I., Ozdilekcan C., and Eren E. Chemoresistant placental site trophoblastic tumor with hilar lymph node metastasis: an unusual site of involvement. Gynecol. Oncol. 96 (2005) 552-555
21. Machtinger R., Gotlieb W.H., Korach J., Fridman E., Apter S., Goldenberg M., et al. Placental site trophoblastic tumor: outcome of five cases including fertility preserving management. Gynecol. Oncol. 96 (2005) 56-61
22. Gulati D., Bahal A., Tevatia M.S., Mehta A., and Muttagikar M.P. Placental site trophoblastic tumour-a case report. Indian J. Pathol. Microbiol. 49 (2006) 281-283
23. Newlands E.S., Mulholland P.J., Holden L., Seckl M.J., and Rustin G.J. Etoposide and cisplatin/etoposide, methotrexate, and actinomycin D (EMA) chemotherapy for patients with high-risk gestational trophoblastic tumors refractory to EMA/cyclophosphamide and vincristine chemotherapy and patients presenting with metastatic placental site trophoblastic tumors. J. Clin. Oncol. 18 (2000) 854-859
24. Aoki Y., Kase H., Kashima K., Yahata T., and Tanaka K. Placental site trophoblastic tumor presenting as subaponeurotic metastasis. Int. J. Gynecol. Cancer. 15 (2005) 385-388
25. Behtash N., Ghaemmaghami F., and Hasanzadeh M. Long term remission of metastatic placental site trophoblastic tumor (PSTT): Case report and review of literature. World J. Surg. Oncol. 3 (2005) 34
26. Palmieri C., Fisher R.A., Sebire N.J., Lindsay I., Smith J.R., McCluggage W.G., et al. Placental site trophoblastic tumour arising from a partial hydatidiform mole. Lancet 366 (2005) 688
27. Jeremic K., Gojnic M., Milenkovic V., Boskovic V., Berisavac M., and Zecević N. Placental site trophoblastic tumor: a case report. Eur. J. Gynaecol. Oncol. 27 (2006) 98-100
28. Raza A., Ahmad Z., and Muzzaffar S. Placental site trophoblastic tumor (PSTT) with metastases to lungs and adrenal glands. J. Coll. Physicians Surg. Pak. 16 (2006) 150-151
29. Khan S., Dancey G., Lindsay I., Sebire N.J., Fisher R.A., Seckl M.J., et al. Placental site trophoblastic tumour derived from an oocyte donation pregnancy. BJOG 113 (2006) 344-346
30. Gupta N., Mittal S., Misra R., Vimala N., and Das A.K. Placental site trophoblastic tumor originating in a tubal ectopic pregnancy. Eur. J. Obstet. Gynecol. Reprod. Biol. 129 (2006) 92-94
31. Zhao J., Xiang Y., Wan X.R., Cui Q.C., and Yang X.Y. Clinical and pathologic characteristics and prognosis of placental site trophoblastic tumor. J. Reprod. Med. 51 (2006) 939-944
32. Numnum T.M., Kilgore L.C., Conner M.G., and Straughn Jr. J.M. Fertility sparing therapy in a patient with placental site trophoblastic tumor: a case report. Gynecol. Oncol. 103 (2006) 1141-1143
33. Piura B., Rabinovich A., Meirovitz M., and Shaco-Levy R. Placental site trophoblastic tumor: report of four cases and review of literature. Int. J. Gynecol. Cancer. 17 (2007) 258-262
34. Bayram I., Senol S., Ozen S., and Sahin G.H. Placental site trophoblastic tumor and concomitant primary ovarian leiomyoma in a postmenopausal woman. Am. J. Clin. Oncol. 30 (2007) 97-98
35. Hemalatha A.L., Kumar D.B., Sumanth D., Abhishek M.G., and Shashidhar H.B. Placental site trophoblastic tumour: a case report. Indian. J. Pathol. Microbiol. 50 (2007) 581-583
36. Batra V., Kalra O.P., Mathur P., and Kavita D.G. Membranous glomerulopathy associated with placental site trophoblastic tumour: a case report. Nephrol. Dial. Transplant. 22 (2007) 1766-1768
37. Milingos D., Doumplis D., Savage P., Seckl M., Lindsay I., and Smith J.R. Placental site trophoblastic tumor with an ovarian metastasis. Int. J. Gynecol. Cancer 17 (2007) 925-927
38. Pfeffer P.E., Sebire N., Lindsay I., McIndoe A., Lim A., and Seckl M.J. Fertility-sparing partial hysterectomy for placental-site trophoblastic tumour. Lancet. Oncol. 8 (2007) 744-746
39. Pai S.A., Kini D., Deo R.P., and Patil P.U. Metastatic placental site trophoblastic tumour in the duodenum presenting with a gastrointestinal bleed. J. Clin. Pathol. 60 (2007) 1295-1296
40. Cole M.E., Broaddus R., Thaker P., Landen C., and Freedman R.S. Placental-site trophoblastic tumors: a case of resistant pulmonary metastasis. Nat. Clin. Pract. Oncol. 5 (2008) 171-175
41. Moodley M. Placental site trophoblastic tumor with antecedent molar pregnancy in association with human immunodeficiency virus infection. Int. J. Gynecol. Cancer 18 (2008) 860-861
42. Nieves L., Hoffman J., Allen G., Currie J., and Sorosky J.I. Placental-site trophoblastic tumor with PET scan-detected surgically treated lung metastasis. Int. J. Clin. Oncol. 13 (2008) 263-265
43. Eckstein R.P., Paradinas F.J., and Bagshawe K.D. Placental site trophoblastic tumour (trophoblastic pseudotumour): a study of four cases requiring hysterectomy including one fatal case. Histopathology 6 (1982) 211-226
44. Berkowitz B.J., Jones J.G., Merkatz I.R., and Runowicz C.D. Ovarian conservation in placental site trophoblastic tumor. Gynecol. Oncol. 37 (1990) 239-243
45. Horn L.C., Göretzlehner U., and Dirnhofer S. Placental site trophoblastic tumor (PSTT) initially misdiagnosed as cervical carcinoma. Pathol. Res. Pract. 193 (1997) 225-230 discussion 231-4
46. Carlson N., Winter III W.E., Krivak T.C., Crothers B., Macri C., and Carlson J.W. Successful management of metastatic placental site trophoblastic tumor with multiple pulmonary resections. Gynecol. Oncol. 87 (2002) 146-149
47. Bonazzi C., Urso M., Dell'Anna T., Sacco S., Buda A., and Cantú M.G. Placental site trophoblastic tumor: an overview. J. Reprod. Med. 49 (2004) 585-588
48. Nigam S., Singhal N., Kumar Gupta S., Chhabra D., and Manaktala U. Placental site trophoblastic tumor in a postmenopausal female-a case report. Gynecol. Oncol. 93 (2004) 550-553
49. McLellan R., Buscema J., Currie J.L., and Woodruff J.D. Placental site trophoblastic tumor in a postmenopausal woman. Am. J. Clin. Pathol. 95 (1991) 670-675
50. Wan X., Yang X., Xiang Y., Wu Y., Yang Y., Ying S., et al. Floxuridine-containing regimens in the treatment of gestational trophoblastic tumor. J. Reprod. Med. 49 (2004) 453-456
51. DiSaia P.J., and Creasman W.T. Gestational trophblastic disease. In: DiSaia P.J., and Creasman W.T. (Eds). Clinical gynaecologic oncology. 5th ed. (1997), Mosby-Year Book, St. Louis 199-200
52. Gillespie A.M., Liyim D., Goepel J.R., Coleman R.E., and Hancock B.W. Placental site trophoblastic tumour: a rare but potentially curable cancer. Br. J. Cancer 82 (2000) 1186-1190
53. Lathrop J.C., Lauchlan S., Nayak R., and Ambler M. Clinical characteristics of placental site trophoblastic tumor (PSTT). Gynecol. Oncol. 31 (1988) 32-42
54. Vardar M.A., and Altintas A. Placental-site trophoblastic tumor. Principles of diagnosis, clinical behaviour and treatment. Eur. J. Gynaecol. Oncol. 16 (1995) 290-295
55. Alvero R., Remmenga S., O'Connor D., Barnhill D., and Park R. Metastatic placental site trophoblastic tumor. Gynecol. Oncol. 37 (1990) 445-449
56. Mariani A., Dowdy S.C., Cliby W.A., Gostout B.S., Jones M.B., Wilson T.O., et al. Prospective assessment of lymphatic dissemination in endometrial cancer: a paradigm shift in surgical staging. Gynecol. Oncol. 109 (2008) 11-18
57. FIGO Oncology Committee. FIGO staging for gestational trophoblastic neoplasia 2000. FIGO Oncology Committee. Int. J. Gynaecol. Obstet. 77 (2002) 285-287