A novel, non-invasive 13C-glucose breath test to estimate insulin resistance in obese prepubertal children

Journal of Pediatric Endocrinology and Metabolism

Volumn 22, Issue 11, 2009, Pages 1051-1059

  Jetha, Mary M ^a   Nzekwu, Ugo ^a   Lewanczuk, Richard Z ^a   Ball, Geoff D C ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

HOMA; Insulin resistance; Obesity; Pediatrics; Prepubertal; Type 2 diabetes mellitus

Indexed keywords

GLUCOSE; GLUCOSE C 13; GLUCOSE DERIVATIVE; INSULIN; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ARTICLE; BREATH ANALYSIS; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DIET RESTRICTION; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTERMETHOD COMPARISON; MALE; NON INVASIVE MEASUREMENT; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PREPUBERTY; SCHOOL CHILD;

EID: 75749139741     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: 10.1515/JPEM.2009.22.11.1051     Document Type: Article

References (27)

1. Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 2006; 295: 1549-1555.
2. Shields M. Overweight and obesity among children and youth. Health Reports 2006; 17: 27-42.
3. American Diabetes Association. American Diabetes Association 2008 clinical practice recommendations. Diabetes Care 2008; 31: S1-S108.
4. Canadian Diabetes Association. Canadian Diabetes Association 2003 clinical practice guidelines for the prevention and management of diabetes in Canada. Can J Diabetes 2003; 27: S1-S147.
5. Kitabchi AE, Temprosa M, Knowler WC, Kahn SE, Fowler SE, Haffner SM, Andres R, Saudek C, Edelstein SL, Arakaki R, Murphy MB, Shamoon H; the Diabetes Prevention Program Research Group. Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the diabetes prevention program: effects of lifestyle intervention and metformin. Diabetes 2005; 54: 2404-2414.
6. Atabek ME, Pirgon O. Use of metformin in obese adolescents with hyperinsulinemia: a 6-month, randomized, double-blind, placebo-controlled clinical trial. J Pediatr Endocrinol Metab 2008; 21: 339-348.
7. Shaibi GQ, Cruz ML, Ball GD, Weigensberg MJ, Salem GJ, Crespo NC, Goran MI. Effects of resistance training on insulin sensitivity in overweight Latino adolescent males. Med Sci Sports Exerc 2006; 38: 1208-1215.
8. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979; 237: E214-E223.
9. Bergman RN, Ider YZ, Bowden CR, Cobelli C. Quantitative estimation of insulin sensitivity. Am J Physiol 1979; 236: E667-E677.
10. Keskin M, Kurtoglu S, Kendirci M, Atabek E, Yazici C. Homeostasis model assessment is more reliable that the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics 2005; 155: e500-e503.
11. Weigensberg MJ, Cruz ML, Goran MI. Association between insulin sensitivity and post-glucose challenge plasma insulin values in overweight Latino youth. Diabetes Care 2003; 26: 2094-2099.
12. Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, Quon MJ. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metabol 2000; 85: 2402-2410.
13. Zannoili R, Rebeggiani A, Chiarelli F, Morgese G. Hyperinsulinism as a marker in obese children. Am J Dis Child 1993; 147: 837-841.
14. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
15. Schwartz B, Jacobs DR, Moran A, Steinberger J, Hong C-P, Sinaiko AR. Measurement of insulin sensitivity in children. Diabetes Care 2008; 31: 783-788.
16. Gungor N, Saad R, Janosky JE, Arslanian S. Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescents. J Pediatr 2004; 144: 47-55.
17. Conwell LS, Trost SG, Brown WJ, Batch JA. Indexes of insulin resistance and secretion in obese children and adolescents: a validation study. Diabetes Care 2004, 27: 314-319.
18. Uwaifo GI, Fallon FM, Chin J, Elberg J, Parinkh SJ, Yanovski JA. Indices of insulin action, disposal and secretion derived from fasting samples and clamps in normal glucose-tolerant black and white children. Diabetes Care 2002; 25: 2081-2087.
19. Hamilton JG. Needle phobia: a neglected diagnosis. J Fam Pract 1995; 41: 169-175.
20. 13 glucose breath test to the hyperinsulinemic-euglycemic clamp when determining insulin resistance. Diabetes Care 2004; 27: 441-447.
21. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986; i: 307-310.
22. Zimmet P, Alberti KG, Kaufman F, Tajima N, Silink M, Arslanian S, Wong G, Bennett P, Shaw J, Caprio S; IDF Consensus Group. The metabolic syndrome in children and adolescents - an IDF consensus report. Pediatr Diabetes 2007; 8: 299-306.
23. Lee JM, Okumura MJ, Davis MM, Herman WH, Gurney JG. Prevalence and determinants of insulin resistance among U.S. adolescents: a population-based study. Diabetes Care 2006; 29: 2427-2432.
24. Tresaco B, Bueno G, Pineda I, Moreno LA, Garagorri JM, Bueno M. Homeostatic model assessment (HOMA) index cut-off values to identify the metabolic syndrome in children. J Physiol Biochem 2005; 61: 381-388.
25. Ball GDC, Huang TT-K, Cruz ML, Shaibi GQ, Weigensberg MJ, Gower BA, Goran MI. A longitudinal study of pubertal insulin resistance and β-cell function in Caucasian and African-American youth. J Pediatr 2006; 148: 16-22.
26. Goran MI, Bergman RN, Cruz ML, Watanabe R. Insulin resistance and associated compensatory responses in African-American and Hispanic children. Diabetes Care 2002; 25: 2184-2190.
27. Arslanian S, Suprasongian C. Differences in the in vivo insulin secretion and sensitivity of healthy black versus white adolescents. J Pediatr 1996; 129: 440-443.