Isolation, synthesis and structures of ginsenoside derivatives and their anti-tumor bioactivity

Molecules

Volumn 15, Issue 1, 2010, Pages 399-406

  Han, Mei ^a   Hou, Jin Gang ^a   Dong, Cheng Ming ^b   Li, Wei ^a,c   Yu, Hao Lun ^a   Zheng, Yi Nan ^a   Chen, Li ^c  

^a Juin Agricultural University   (China)

^b HENAN UNIVERSITY OF CHINESE MEDICINE   (China)

^c Basic Medical College   (China)

Author keywords

Isolation, synthesis, ginsenoside orh1

Indexed keywords

ANTINEOPLASTIC AGENT; GINSENOSIDE; PROTOPANAXATRIOL; SAPOGENIN;

ANIMAL; ARTICLE; CHEMISTRY; DRUG SCREENING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ISOLATION AND PURIFICATION; MOUSE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG SCREENING ASSAYS, ANTITUMOR; GINSENOSIDES; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; SAPOGENINS;

EID: 75749126934     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules15010399     Document Type: Article

References (19)

1. Balsiger, B.M.; Murr, M.M.; Poggio, J.L.; Sarr, M.G. Bariatric surgery: Surgery for weight control in patients with morbid obesity. Med. Clin. N. Amer. 2000, 84, 477-489. (Pubitemid 30176633)
2. Niti, S.; Vinay, K.S.; Seo, S.Y. Screening of some medicinal plants foe anti-lipase activity. J. Ethnopharmacol. 2005, 97, 453-456. (Pubitemid 40312318)
3. Attelé, A.S.; Wu, J.A.; Yuan, C.S. Ginseng pharmacology: Multiple constituents and multiple actions. Biochem. Pharmacol. 1999, 58, 1685-1693. (Pubitemid 29505408)
4. Li, T.S.C. Asian and American ginseng: A review. Hort Technol. 1995, 5, 27-34.
5. Karu, N.; Reifen, R.; Kerem, Z. Weight gain reduction in mice fed panax ginseng saponin, a pancreatic lipase inhibitor. J. Agric. Food Chem. 2007, 55, 2824-2828. (Pubitemid 46668284)
6. Park, E.K.; Choo, M.K.; Han, M.J.; Kim, D.H. Ginsenoside Rh1 possesses antiallergic and anti-inflammatory activities. Int. Arch. Allergy Immunol. 2004, 133, 113-120.
7. Ki, S.K.; Noriko, Y.; Kim, H.Y.; Takuya, O.; Yasuo, S.; Takako, Y. Increase in the free radical scavenging activities of American ginseng by heat processing and its safety evaluation. J. Ethnopharmacol. 2007, 113, 225-232.
8. Hu, C.; Kitts, D. Free radical scavenging capacity as related to antioxidant activity and ginsenoside composition of Asian and North American ginseng extracts. J. Amer. Oil Chem. Soc. 2001, 78, 249-255. (Pubitemid 32419479)
9. Liu, W.C.; Zheng, Y.N.; Masato, S.; Wang, H.M.; Yoshiyuki, K.; Ling, M.S.; Feng, Y.X. Saponins from stems and leaves of Panax quinquefolium prevented high fat diet-induced obesity in mice. Phytomedicine 2008, 15, 1140-1145.
10. Lee, Y.N.; Lee, H.Y.; Chung, H.Y.; Kim, S.I.; Lee, S.K.; Park, B.C.; Kim, K.W. In vitro induction of differentiation by ginsenosides in F9 etratocarcinoma cells. Eur. J. Cancer 1996, 32A, 1420-1428. (Pubitemid 26246720)
11. Kang, J.; Lee, Y.; No, K.; Jung, E.; Sung, J.; Kim, Y.; Nam, S. Ginseng intestinal metabolite-I (GIM-I) reduces doxorubicin toxicity in the mouse testis [J]. Reprod. Toxicol. 2002, 16, 291-298. (Pubitemid 34966268)
12. Tawab, M.; Bahr, U.; Karas, M.; Wurglics, M. Degeneration of ginsenosides in humans after oral administration. Drug Metab. Dispos. 2003, 31, 1065-1071. (Pubitemid 36975678)
13. Hasegawa, H.; Lee, K.; Nagaoka, T.; Tezuka, Y.; Uchiyama, M.; Kadota, S.; Saiki, I. Pharmacokinetics of ginsenoside deglycosylated by intestinal bacteria and its transformation to biologically active fatty acid esters. Biol. Pharm. Bull. 2000, 23, 298-304. (Pubitemid 30187274)
14. Lei, J.; Li, X.; Gong, X.J.; Zheng, Y.N. Isolation, synthesis and structures of cytotoxic ginsenoside derivatives. Molecules 2007, 12, 2140-2150.
15. Keum, Y.S.; Han, S.S.; Chun, K.S.; Park, K.K.; Park, J.H.; Lee, S.K.; Surh, Y.J. Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-kappaB activation and tumor promotion. Mutat. Res. 2003, 523-524, 75-85.
16. Kim, S.W.; Kwon, H.Y.; Chi, D.W.; Shim, J.H.; Park, J.D.; Lee, Y.H.; Pyo, S.; Rhee, D.K. Reversal of P-glycoprotein-mediated multidrug resistance by ginsenoside Rg (3). Biochem. Pharmacol. 2003, 65, 75-82. (Pubitemid 35447841)
17. Popovich, D.; Kitts, D., Structure-function relationship exists for ginsenosides in reducing cell proliferation and inducingapoptosis in the human leukemia (THP-1) cell line. Arch. Biochem. Biophys. 2002, 406, 1-8. (Pubitemid 35191710)
18. Popovich, D.G.; Kitts, D.D. Ginsenosides can inhibit proliferation and induce apoptosis in cultured leukemia and intestinal cells but effects vary according to the structure of the compounds. FASEBJ. 2003, 17, A762.
19. Park, J.A.; Lee, K.Y.; Oh, Y.J; Kim, K.W.; Lee, S.K. Activation of caspase-3 protease via a Bcl-2-insensitive pathway during the process of ginsenoside Rh2-induced apoptosis. Cancer Lett. 1997, 121, 73-81.