Knockdown of RCAN1.4 increases susceptibility to FAS-mediated and DNA-damage-induced apoptosis by upregulation of p53 expression

Korean Journal of Physiology and Pharmacology

Volumn 13, Issue 6, 2009, Pages 483-489

  Kim, Young Sun ^a   Lee, Hong Joon ^a   Jang, Chorong ^a   Kim, Ho Shik ^a   Cho, Young Jin ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

Apoptosis; Bax; HDM2; p53; RCAN1

Indexed keywords

ETOPOSIDE; FAS ANTIGEN; HUMAN REGULATOR OF CALCINEURIN 1 PROTEIN; PROTEIN BAX; PROTEIN MDM2; PROTEIN P53; REGULATOR PROTEIN; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL STRESS; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; GENE DELETION; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MITOCHONDRION; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RNA TRANSLATION; UPREGULATION;

EID: 75749126534     PISSN: 12264512     EISSN: None     Source Type: Journal    
DOI: 10.4196/kjpp.2009.13.6.483     Document Type: Article

References (27)

1. Banin S, Moyal L. Shieh S, Taya Y, Anderson CW, Chessa L, Smorodinsky NI, Prives C, Reiss Y, Shiloh Y, Ziv Y. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 281: 1674-1677, 1998.
2. Barak Y, Juven T, Haffner R, Oren M. Mdm2 expression is induced by wild type p53 activity. EMBO J 12: 461-468, 1993.
3. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appelle E, Kastan MB, Siliciano JD. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281: 1677-1679, 1998.
4. De Benedetti A, Graff JR .eIF-4E expression and its role in malignancies and metastases. Oncogene 23: 3189-3199, 2004.
5. Ermak G, Harris CD, Davies KJ. The DSCR1 (Adapt78) isoform 1 protein calcipressin 1 inhibits calcineurin and protects against acute calcium-mediated stress damage, including transient oxidative stress. FASEB J 16: 814-824, 2002.
6. Ermak G, Morgan TE, Davies KJ. Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease. J Biol Chem 276: 38787-38794, 2001.
7. Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J Biol Chem 275: 8945-8951, 2000.
8. Fuentes JJ, Genesca L, Kingsbury TJ, Cunningham KW, Perez-Riba M, Estivill X, de la Luna S. DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. Hum Mol Genet 9: 1681-1690, 2000.
9. Fuentes JJ, Pritchard MA, Estivill X. Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene. Genomics 44: 358-361, 1997.
10. Fuentes JJ, Pritchard MA, Planas AM, Bosch A, Ferrer I, Estivill X. A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart. Hum Mol Genet 4: 1935-1944, 1995.
11. Harris CD, Ermak G, Davies KJ. Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product calcipressin 1 (or RCAN1) in disease. Cell Mol Life Sci 62: 2477-2486, 2005.
12. Head E, Lott IT, Patterson D, Doran E, Haier RJ. Possible compensatory events in adult Down syndrome brain prior to the development of Alzheimer disease neuropathology: targets for nonpharmacological intervention. J Alzheimers Dis 11: 61-76, 2007.
13. Hsu YT, Wolter KG, Youle RJ. Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis. Proc Natl Acad Sci U S A 94: 3668-3672, 1997.
14. Kubbutat MH, Jones SN, Vousden KH. Regulation of p53 stability by Mdm2. Nature 387: 299-303, 1997.
15. Kubbutat MH, Ludwig RL. Ashcroft M, Vousden KH. Regulation of Mdm2-directed degradation by the C terminus of p53. Mol Cell Biol 18: 5690-5698, 1998.
16. Lee HJ, Kim YS, Sato Y, Cho YJ. RCAN1-4 knockdown attenuates cell growth through the inhibition of Ras signaling. FEBS Lett 583: 2557-2564, 2009.
17. Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Liebermann DA, Hoffman B, Reed JC. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9: 1799-1805, 1994.
18. Porta S, Serra SA, Huch M, Valverde MA, Llorens F, Estivill X, Arbones ML. Marti E. RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: a potential pathogenic process in neurodegeneration. Hum Mol Genet 16: 1039-1050, 2007.
19. Prives C. Signaling to p53: breaking the MDM2-p53 circuit. Cell 95: 5-8, 1998.
20. Rothermel B, Vega RB, Yang J, Wu H, Bassel-Duby R Williams RS. A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. J Biol Chem 275: 8719-8725, 2000.
21. Ryeom S, Baek KH, Rioth MJ, Lynch RC, Zaslavsky A, Birsner A, Yoon SS, McKeon F. Targeted deletion of the calcineurin inhibitor DSCR1 suppresses tumor growth. Cancer Cell 13: 420 -431, 2008.
22. Ryeom S, Greenwald RJ, Sharpe AH, McKeon F. The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin. Nat Immunol 4: 874-881, 2003.
23. Sanna B, Brandt EB, Kaiser RA, Pfluger P, Witt SA, Kimball TR, van Rooij E, De Windt LJ, Rothenberg ME, Tschop MH, Benoit SC, Molkentin JD. Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo. Proc Natl Acad Sci U S A 103: 7327-7332, 2006.
24. Vousden KH, Lu X. Live or let die: the cell's response to p53. Nat Rev Cancer 2: 594-604, 2002.
25. Wolter KG, Hsu YT, Smith CL, Nechushtan A, Xi XG, Youle RJ. Movement of Bax from the cytosol to mitochondria during apoptosis. J Cell Biol 139: 1281-1292, 1997.
26. Wu X, Bayle JH, Olson D, Levine AJ. The p53-mdm-2 autoregulatory feedback loop. Genes Dev 7: 1126-1132, 1993.
27. Zhao P, Xiao X, Kim AS, Leite MF, Xu J, Zhu X, Ren J, Li J. c-Jun inhibits thapsigargin-induced ER stress through up-regulation of DSCR1/Adapt78. Exp Biol Med (Maywood) 233: 1289-1300, 2008.