Physical activity and lung cancer among non-smokers: A pilot molecular epidemiological study within EPIC

Biomarkers

Volumn 15, Issue 1, 2010, Pages 20-30

  Rundle, Andrew ^a   Richie, John ^b   Steindorf, Karen ^c   Peluso, Marco ^d   Overvad, Kim ^e   Raaschou Nielsen, Ole ^f   Clavel Chapelon, Francoise ^g   Linseisen, Jacob P ^c   Boeing, Heiner ^h   Trichopoulou, Antonia ⁱ   Palli, Domenico ^d   Krogh, Vittorio ^j   Tumino, Rosario ^k   Panico, Salvatore ^l   Bueno De Mesquita, Hendrik B ^m   Peeters, Petra H ^n,o   Lund, Eiliv ^p   Gonzalez, Carlos A ^q   Martinez, Carmen ^r   Dorronsoro, Miren ^s   Barricarte, Aurelio ^t   Tormo, M Jose ^u   Quiros, José R ^v   Agudo, Antonio ^q   Berglund, Goran ^w   Jarvholm, Bengt ^x   Bingham, Sheila ^y,z   Key, Timothy J ^aa   Gormally, Emmanuelle ^ab,ac   Saracci, Rodolfo ^ad   Kaaks, Rudolf ^ae   Riboli, Elio ^o   Vineis, Paolo ^o,af   more..

^a School of Public Health ^*  (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d CANCER RESEARCH AND PREVENTION INSTITUTE ISPO   (Italy)

^e AALBORG UNIVERSITY HOSPITAL   (Denmark)

^f INSTITUTE OF CANCER EPIDEMIOLOGY   (Denmark)

^g INSERM   (France)

^h GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

ⁱ UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^j NATIONAL CANCER INSTITUTE   (Italy)

^k CIVILE M P AREZZO HOSPITAL   (Italy)

^l UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^m NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

ⁿ UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^o IMPERIAL COLLEGE LONDON   (United Kingdom)

^p UNIVERSITY OF TROMSØ   (Norway)

^q CATALAN INSTITUTE OF ONCOLOGY   (Spain)

^r ANDALUSIAN SCHOOL OF PUBLIC HEALTH   (Spain)

^s Andalusian School of Public Health ^*  (Spain)

^t INSTITUTO DE SALUD PÚBLICA DE NAVARRA   (Spain)

^u DEPARTMENT OF EPIDEMIOLOGY   (Spain)

^v Direccion General de Salud Publica   (Spain)

^w LUND UNIVERSITY   (Sweden)

^x UMEÅ UNIVERSITY   (Sweden)

^y UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^z UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^aa UNIVERSITY OF OXFORD   (United Kingdom)

^ab INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^ac UNIVERSITÉ CATHOLIQUE DE LYON   (France)

^ad CNR   (Italy)

^ae Division of Clinical Epidemiology   (Germany)

^af UNIVERSITY OF TURIN   (Italy)

more..

Author keywords

Biomarkers; Lung cancer; Molecular epidemiology; Physical activity

Indexed keywords

BIOLOGICAL MARKER; GLUTATHIONE; HEMOGLOBIN; PHOSPHORUS 32;

ADULT; AGED; ARTICLE; CANCER RISK; CONTROLLED STUDY; DNA ADDUCT; ERYTHROCYTE; FEMALE; HUMAN; LEUKOCYTE; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; MOLECULAR EPIDEMIOLOGY; PHYSICAL ACTIVITY; SMOKING;

AGED; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; DNA ADDUCTS; ERYTHROCYTES; EUROPE; FEMALE; GLUTATHIONE; HUMANS; LEUKOCYTES; LUNG NEOPLASMS; MALE; MIDDLE AGED; MOLECULAR EPIDEMIOLOGY; MOTOR ACTIVITY; PILOT PROJECTS; RISK FACTORS; SMOKING;

EID: 75749126106     PISSN: 1354750X     EISSN: 13665804     Source Type: Journal    
DOI: 10.3109/13547500903186452     Document Type: Article

References (74)

1. Ainsworth B, Haskell W, Whitt M, Irwin M, Swartz A, Strath S, O'Brien W, Bassett D, Schmitz K, Emplaincourt P and others. (2000). Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 32(9 Suppl.):S498-504.
2. Airoldi L, Vineis P, Colombi A, Olgiati L, Dell'Osta C, Fanelli R, Manzi L, Veglia F, Autrup H, Dunning A and others. (2005). 4-Aminobiphenyl-hemoglobin adducts and risk of smoking-related disease in never smokers and former smokers in the European Prospective Investigation into Cancer and Nutrition Prospective Study. Cancer Epidemiol Biomarkers Prev 14:2118-2124
3. Alfano CM, Klesges RC, Murray DM, Bowen DJ, McTiernan A, Vander Weg MW, Robinson LA, Cartmel B, Thornquist MD, Barnett M and others. (2004). Physical activity in relation to all-site and lung cancer incidence and mortality in current and former smokers. Cancer Epidemiol Biomarkers Prev 13:2233-2241
4. Arrighi HM, Hertz-Picciotto I. (1994). The evolving concept of the healthy worker survivor effect. Epidemiology 5:189-196
5. Bak H, Autrup H, Thomsen B, Tjønneland A, Overvad K, Vogel U, Raaschou-Nielsen O, Loft S. (2006). Bulky DNA adducts as risk indicator of lung cancer in a Danish case-cohort study. Int J Cancer 118:1618-1622
6. Bak H, Christensen J, Thomsen BL, Tjonneland A, Overvad K, Loft S, Raaschou-Nielsen O. (2005). Physical activity and risk for lung cancer in a Danish cohort. Int J Cancer 116:439-444
7. Bartsch H, Petruzzelli S, De Flora S, Hietanen E, Camus A, Castegnaro M, Geneste O, Camoirano A, Saracci R, Giuntini C. (1991). Carcinogen metabolism and DNA adducts in human lung tissues as affected by tobacco smoking or metabolic phenotype: a case-control study on lung cancer patients. Mutat Res 250:103-114
8. Boehme D, Hotchkiss J, Henderson R. (1992). Glutathione and GSHdependent enzymes in bronchoalveolar lavage fluid cells in response to ozone. Exp Mol Pathol 56:37-48.
9. Bowles HR, FitzGerald SJ, Morrow JR, Jr., Jackson AW, Blair SN. (2004). Construct validity of self-reported historical physical activity. Am J Epidemiol 160:279-286
10. Boyle RG, O'Connor P, Pronk N, Tan A. (2000). Health behaviors of smokers, ex-smokers, and never smokers in an HMO. Prevent Med 31:177-182
11. Brownson R, Chang J, Davis J, Smith C. (1991). Physical activity on the job and cancer in Missouri. Am J Public Health 81:639-642
12. Cantin A, North S, Hubbard R, Crystal R. (1987). Normal alveolar epithelial lining fluid contains high levels of glutathione. J Appl Physiol 63:152-157
13. Cerutti P. (1985). Prooxidant states and tumor promotion. Science 227:375-381
14. Colbert L, Hartman T, Tangrea J, Pietinen P, Virtamo J, Taylor P, Albanes D. (2002). Physical activity and lung cancer risk in male smokers. Int J Cancer 98:770-773
15. DeVellis R. (1991). Scale development: theory and applications. Newbury Park, CA: Sage.
16. Doherty SC, Steptoe A, Rink E, Kendrick T, Hilton S. (1998). Readiness to change health behaviours among patients at high risk of cardiovascular disease. J Cardiovasc Risk 5:147-153
17. Dosemeci M, Hayes RB, Vetter R, Hoover RN, Tucker M, Engin K, Unsal M, Blair A. (1993). Occupational physical activity, socio economic status, and risks of 15 cancer sites in Turkey. Cancer Causes Control 4:313-321
18. Duncan K, Harris S, Ardies CM. (1997). Running exercise may reduce risk for lung and liver cancer by inducing activity of antioxidant and phase II enzymes. Cancer Lett 116:151-158
19. Emmons KM, Marcus BH, Linnan L, Rossi JS, Abrams DB. (1994). Mechanisms in multiple risk factor interventions: smoking, physical activity, and dietary fat intake among manufacturing workers. Working Well Research Group. Prevent Med 23:481-489
20. Evelo C, Palmen N, Artur Y, Janssen G. (1992). Changes in blood glutathione concentrations, and in erythrocyte glutathione reductase and glutathione S-transferase activity after running training and after participation in contests. Eur J Appl Physiol Occup Physiol 64:354-358
21. Fairbanks V, Klee G. (1987). Biochemical aspects of hematology. In: Tietz N, editor. Fundamentals of clinical chemistry.Philadelphia: WB Saunders Company.
22. Ferlay J, Autier P, Boniol M, Heanue M, Colombet M, Boyle P. (2007). Estimates of the cancer incidence and mortality in Europe in (2006). Ann Oncol 18:581-592 (Pubitemid 46359643)
23. Fishman PA, Khan ZM, Thompson EE, Curry SJ. (2003). Health care costs among smokers, former smokers, and never smokers in an HMO. Health Services Res 38:733-749
24. Frenkel K. (1992). Carcinogen-mediated oxidant formation and oxidative DNA damage. Pharmacol Ther 53:127-166
25. Garrett NA, Alesci NL, Schultz MM, Foldes SS, Magnan SJ, Manley MW. (2004). The relationship of stage of change for smoking cessation to stage of change for fruit and vegetable consumption and physical activity in a health plan population. Am J Health Prom 19:118-127
26. Godschalk RWL, Feldker DEM, Borm PJA, Wouters EFM, Van Schooten F-J. (2002). Body mass index modulates aromatic DNA adduct levels and their persistence in smokers. Cancer Epidemiol Biomarkers Prev 11:790-793
27. Haftenberger M, Schuit AJ, Tormo MJ, Boeing H, Wareham N, Bueno-de-Mesquita HB, Kumle M, Hjartaker A, Chirlaque MD, Ardanaz E and others. (2002). Physical activity of subjects aged 50-64 years involved in the European Prospective Investigation into Cancer and Nutrition (EPIC). Public Health Nutr 5:1163-1176
28. Halpern MT, Warner KE. (1994). Differences in former smokers' beliefs and health status following smoking cessation. Am J Prev Med 10:31-37
29. Hoffman-Goetz L, Apter D, Demark-Wahnefried W, Goran M, McTiernan A, Reichman M. (1998). Possible mechanism mediating an association between physical activity and breast cancer. Cancer 83:621-628
30. Jacobs DR Jr, Ainsworth BE, Hartman TJ, Leon AS. (1993). A simultaneous evaluation of 10 commonly used physical activity questionnaires. Med Sci Sports Exerc 25:81-91.
31. Jernstrom B, Babson J, Moldeus P, Holmgren A, Reed D. (1982). Glutathione conjugation and DNA-binding of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a] pyrene and (+/-)-7 beta,8 alphadihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10- tetrahydrobenzo[a] pyrene in isolated rat hepatocytes. Carcinogenesis 3:861-866
32. Joseph AM, Bliss RL, Zhao F, Lando H. (2005). Predictors of smoking reduction without formal intervention. Nicotine Tob Res 7:277-282
33. Julius M, Lang CA, Gleiberman L, Harburg E, DiFranceisco W, Schork A. (1994). Glutathione and morbidity in a communitybased sample of elderly. J Clin Epidemiol 47:1021-1026
34. Karolkiewicz J, Szczesniak L, Deskur-Smielecka E, Nowak A, Stemplewski R, Szeklicki R. (2003). Oxidative stress and antioxidant defence system in healthy, elderly men: relationship to physical activity. Aging Male 6:100-105
35. Kawada T. (2004). Comparison of daily life habits and health examination data between smokers and ex-smokers suggests that exsmokers acquire several healthy-lifestyle practices. Arch Med Res 35:329-333
36. Kelly F. (1999). Gluthathione: in defence of the lung. Food Chem Toxicol 37:963-966
37. Kubik A, Zatloukal P, Tomasek L, Pauk N, Havel L, Dolezal J, Plesko I. (2007). Interactions between smoking and other exposures associated with lung cancer risk in women: diet and physical activity. Neoplasma 54:83-88
38. Lee I, Paffenbarger R. (1994). Physical activity and its relation to cancer risk: a prospective study of college alumni. Med Sci Sports Exerc 26:831-837
39. Lee I, Sesso H, Paffenbarger R. (1999). Physical activity and risk of lung cancer. Int J Epidemiol 28:620-625
40. Leitzmann MF, Koebnick C, Abnet CC, Freedman ND, Park Y, Hollenbeck A, Ballard-Barbash R, Schatzkin A. (2009). Prospective study of physical activity and lung cancer by histologic type in current, former, and never smokers. Am J Epidemiol 169:542-553
41. Mao Y, Pan S, Wen SW, Johnson KC, Canadian Cancer Registries Epidemiology Research G. (2003). Physical activity and the risk of lung cancer in Canada. Am J Epidemiol 158:564-575
42. McTiernan A, Ulrich C, Slate S, Potter S. (1998). Physical activity and cancer etiology: associations and mechanisms. Cancer Causes Control 9:487-509.
43. Michelet F, Gueguen R, Leroy P, Wellman M, Nicolas A, Siest G. (1995). Blood and plasma glutathione measured in healthy subjects by HPLC: relation to sex, aging, biological variables, and life habits. Clin Chem 41:1509-1517
44. Miyazaki H, Oh-ishi S, Ookawara T, Kizaki T, Toshinai K, Ha S, Haga S, Ji LL, Ohno H. (2001). Strenuous endurance training in humans reduces oxidative stress following exhausting exercise. Eur J Appl Physiol 84:1-6.
45. Nuttall SL, Martin U, Sinclair AJ, Kendall MJ. (1998). Glutathione: in sickness and in health. Lancet 351:645-646
46. Paffenbarger RS Jr, Hyde RT, Wing AL. (1987). Physical activity and incidence of cancer in diverse populations: a preliminary report. Am J Clin Nutr 45(Suppl.):312-317
47. Peluso M, Hainaut P, Airoldi L, Autrup H, Dunning A, Garte S, Gormally E, Malaveille C, Matullo G, Munnia A and others. (2005a). Methodology of laboratory measurements in prospective studies on gene-environment interactions: the experience of GenAir. Mutat Res 574:92-104.
48. Peluso M, Munnia A, Hoek G, Krzyzanowski M, Veglia F, Airoldi L, Autrup H, Dunning A, Garte S, Hainaut P and others. (2005b). DNA adducts and lung cancer risk: a prospective study. Cancer Res 65:8042-8048
49. Pols M, Peeters P, Ocke M, Slimani N, Bueno-De-Mesquita H, Collette H. (1997). Estimation of reproducibility and relative validity of the questions included in the EPIC physical activity questionnaire. Int J Epidemiol 26 (Suppl. 1):s181-9.
50. Richardson D, Wing S, Steenland K, McKelvey W. (2004). Time-related aspects of the healthy worker survivor effect. Ann Epidemiol 14:633-639
51. Richie J, Skowronski L, Abraham P, Leutzinger Y. (1996). Blood glutathione concentrations in a large-scale human study. Clin Chem 42:64-70.
52. Robertson J, Maughan R, Duthie G, Morrice P. (1991). Increased blood antioxidant systems of runners in response to training load. Clin Sci (Colch) 80:611-618
53. Robins J. (1989). The control of confounding by intermediate variables. Stat Med 8:679-701.
54. Robins JM, Hernan MA, Brumback B. (2000). Marginal structural models and causal inference in epidemiology. Epidemiology 11:550-560
55. Rundle A. (2005). The molecular epidemiology of physical activity and cancer. Cancer Epidemiol Biomarkers and Prev 14:227-236
56. Rundle A, Madsen A, Orjuela M, Mooney L, Tang D, Kim M, Perera F. (2007). The association between benzo[a]pyrene-DNA adducts and body mass index, calorie intake and physical activity. Biomarkers 12:123-132
57. Rundle A, Orjuela M, Mooney L, Tang D, Kim M, Calcagnotto A, Richie J, Perera F. (2005a). Moderate physical activity is associated with increased blood levels of glutathione among smokers. Biomarkers 10:3390-3400
58. Rundle AG, Vineis P, Ahsan H. (2005b). Design options for molecular epidemiology research within cohort studies. Cancer Epidemiol Biomarkers Prev 14:1899-1907
59. Severson RK, Nomura AM, Grove JS, Stemmermann GN. (1989). A prospective analysis of physical activity and cancer. Am J Epidemiol 130:522-529
60. Sinner P, Folsom AR, Harnack L, Eberly LE, Schmitz KH. (2006). The association of physical activity with lung cancer incidence in a cohort of older women: the Iowa Women's Health Study. Cancer Epidemiol Biomarkers Prev 15:2359-2363
61. Sprague BL, Trentham-Dietz A, Klein BE, Klein R, Cruickshanks KJ, Lee KE, Hampton JM. (2008). Physical activity, white blood cell count, and lung cancer risk in a prospective cohort study. Cancer Epidemiol Biomarkers Prev 17:2714-2722
62. Steenland K, Nowlin S, Palu S. (1995). Cancer incidence in the National Health and Nutrition Survey I. Follow-up data: diabetes, cholesterol, pulse and physical activity. Cancer Epidemiol Biomarkers Prev 4:807-811
63. Steindorf K, Friedenreich C, Linseisen J, Rohrmann S, Rundle A, Veglia F, Vineis P, Johnsen NF, Tjønneland A, Overvad K and others. (2006). Physical activity and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Int J Cancer 119:2389-2397 (Pubitemid 44546961)
64. Tang D, Phillips D, Stampfer M, Mooney L, Hsu Y, Cho S, Tsai W, Ma J, Cole K, She M and others. (2001). Association between carcinogen-DNA adducts in white blood cells and lung cancer risk in the physicians health study. Cancer Res 61:6708-6712
65. Tang D, Rundle A, Warburton D, Santella R, Tsai W, Chiamprasert S, Hsu Y, Perrera FP. (1998). Associations between both genetic and environmental biomarkers and lung cancer: evidence of a greater risk of lung cancer in women smokers. Carcinogenesis 19:1949-1953
66. Tang J, Muir J, Lancaster T, Jones L, Fowler G. (1997). Health profiles of current and former smokers and lifelong abstainers. OXCHECK Study Group. OXford and Collaborators HEalth ChecK. J R Coll Phys London 31:304-309
67. Thune I. (2000). Assessments of physical activity and cancer risk. Eur J Can Prev 9:387-393
68. Thune I, Lund E. (1997). The influence of physical activity on lungcancer risk: a prospective study of 81,516 men and women. Int J Cancer 70:57-62.
69. Twardella D, Loew M, Rothenbacher D, Stegmaier C, Ziegler H, Brenner H. (2006). The diagnosis of a smoking-related disease is a prominent trigger for smoking cessation in a retrospective cohort study. J Clin Epidemiol 59:82-89
70. Veglia F, Loft S, Matullo G, Peluso M, Munnia A, Perera F, Phillips DH, Tang D, Autrup H, Raaschou-Nielsen O and others. (2008). DNA adducts and cancer risk in prospective studies: a pooled analysis and a meta-analysis. Carcinogenesis 29:932-936
71. Veglia F, Matullo G, Vineis P. (2003). Bulky DNA adducts and risk of cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prev 12:157-160
72. Wagner EH, Curry SJ, Grothaus L, Saunders KW, McBride CM. (1995). The impact of smoking and quitting on health care use. Arch Intern Med 155:1789-1795
73. Washburn RA, Smith KW, Goldfield SR, McKinlay JB. (1991). Reliability and physiologic correlates of the Harvard Alumni Activity Survey in a general population. J Clin Epidemiol 44:1319-1326
74. Yun YH, Lim MK, Won YJ, Park SM, Chang YJ, Oh SW, Shin SA. (2008). Dietary preference, physical activity, and cancer risk in men: national health insurance corporation study. BMC Cancer 8:366.