Newly identified antibacterial compounds are topoisomerase poisons in African trypanosomes

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 2, 2010, Pages 620-626

  Tang, Sonya C ^a   Shapiro, Theresa A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (PIPERIDIN 1 YLMETHYL)INDENO[1,2,3 DE]PHTHALAZIN 3 (2H)ONE; ANTITRYPANOSOMAL AGENT; CAMPTOTHECIN; CIPROFLOXACIN; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); EFLORNITHINE; ETOPOSIDE; N,N DIMETHYL 2 (PHENANTHRO[3,4 D][1,3]DIOXOL 5 YL)ETHANAMINE; PENTAMIDINE; UNCLASSIFIED DRUG;

AFRICAN TRYPANOSOMIASIS; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; COVALENT BOND; CYTOTOXICITY; DRUG ACTIVITY; DRUG MECHANISM; DRUG STRUCTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; TRYPANOCIDAL ACTIVITY;

ANIMALS; BLOTTING, WESTERN; DNA TOPOISOMERASES, TYPE I, EUKARYOTIC; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA, KINETOPLAST; HUMANS; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PROTEIN BINDING; PROTOZOAN PROTEINS; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

EID: 75749119689     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01025-09     Document Type: Article

References (29)

1. Abramoff, M. D., P. J. Magelhaes, and S. J. Ram. 2004. Image processing with Image J. Biophotonics Int. 11:36-42.
2. Aguero, F., B. Al-Lazikani, M. Aslett, M. Berriman, F. S. Buckner, R. K. Campbell, S. Carmona, I. M. Carruthers, A. W. Chan, F. Chen, G. J. Crowther, M. A. Doyle, C. Hertz-Fowler, A. L. Hopkins, G. McAllister, S. Nwaka, J. P. Overington, A. Pain, G. V. Paolini, U. Pieper, S. A. Ralph, A. Riechers, D. S. Roos, A. Sali, D. Shanmugam, T. Suzuki, W. C. Van Voorhis, and C. L. Verlinde. 2008. Genomic-scale prioritization of drug targets: the TDR Targets database. Nat. Rev. Drug Discov. 7:900-907.
3. Barrett, M. P., R. J. Burchmore, A. Stich, J. O. Lazzari, A. C. Frasch, J. J. Cazzulo, and S. Krishna. 2003. The trypanosomiases. Lancet 362:1469-1480.
4. Bodley, A. L., M. W. McGarry, and T. A. Shapiro. 1995. Drug cytotoxicity assay for African trypanosomes and Leishmania species. J. Infect. Dis. 172:1157-1159.
5. Bodley, A. L., and T. A. Shapiro. 1995. Molecular and cytotoxic effects of camptothecin, a topoisomerase I inhibitor, on trypanosomes and Leishmania. Proc. Natl. Acad. Sci. U. S. A. 92:3726-3730.
6. Borst, P., M. van der Ploeg, J. F. van Hoek, J. Tas, and J. James. 1982. On the DNA content and ploidy of trypanosomes. Mol. Biochem. Parasitol. 6:13-23.
7. Champoux, J. J. 2001. DNA topoisomerases: structure, function, and mechanism. Annu. Rev. Biochem. 70:369-413.
8. Cheng, B., I. F. Liu, and Y. C. Tse-Dinh. 2007. Compounds with antibacterial activity that enhance DNA cleavage by bacterial DNA topoisomerase I. J. Antimicrob. Chemother. 59:640-645.
9. Corbett, K. D., and J. M. Berger. 2004. Structure, molecular mechanisms, and evolutionary relationships in DNA topoisomerases. Annu. Rev. Biophys. Biomol. Struct. 33:95-118.
10. Fairlamb, A. H. 2003. Chemotherapy of human African trypanosomiasis: current and future prospects. Trends Parasitol. 19:488-494.
11. Froelich-Ammon, S. J., and N. Osheroff. 1995. Topoisomerase poisons: harnessing the dark side of enzyme mechanism. J. Biol. Chem. 270:21429-21432.
12. Holford, N. H., and L. B. Sheiner. 1981. Understanding the dose-effect relationship: clinical application of pharmacokinetic- pharmacodynamic models. Clin. Pharmacokinet. 6:429-453.
13. Jensen, R. E., L. Simpson, and P. T. Englund. 2008. What happens when Trypanosoma brucei leaves Africa. Trends Parasitol. 24:428-431.
14. Kaufmann, S. H., and P. Svingen. 1999. Immunoblot analysis and band depletion assays, p. 253-268. In M. Bjornsti and N. Osheroff (ed.), DNA topoisomerase protocols, vol. 1. DNA topology and enzymes. Humana Press Inc., Totowa, NJ.
15. Kulikowicz, T., and T. A. Shapiro. 2006. Distinct genes encode type II topoisomerases for the nucleus and mitochondrion in the protozoan parasite Trypanosoma brucei. J. Biol. Chem. 281:3048-3056.
16. Liu, B., Y. Liu, S. A. Motyka, E. E. Agbo, and P. T. Englund. 2005. Fellowship of the rings: the replication of kinetoplast DNA. Trends Parasitol. 21:363-369.
17. Liu, L. F. 1989. DNA topoisomerase poisons as antitumor drugs. Annu. Rev. Biochem. 58:351-375.
18. Nenortas, E., C. Burri, and T. A. Shapiro. 1999. Antitrypanosomal activity of fluoroquinolones. Antimicrob. Agents Chemother. 43:2066-2068.
19. Pommier, Y., J. K. Minford, R. E. Schwartz, L. A. Zwelling, and K. W. Kohn. 1985. Effects of the DNA intercalators 4′-(9-acridinylamino) methanesulfon-m-anisidide and 2-methyl-9-hydroxyellipticinium on topoisomerase II mediated DNA strand cleavage and strand passage. Biochemistry 24:6410-6416.
20. Pommier, Y., R. E. Schwartz, L. A. Zwelling, and K. W. Kohn. 1985. Effects of DNA intercalating agents on topoisomerase II induced DNA strand cleavage in isolated mammalian cell nuclei. Biochemistry 24:6406-6410.
21. Scocca, J. R., and T. A. Shapiro. 2008. A mitochondrial topoisomerase IA essential for late theta structure resolution in African trypanosomes. Mol. Microbiol. 67:820-829.
22. Shapiro, T. A., and P. T. Englund. 1990. Selective cleavage of kinetoplast DNA minicircles promoted by antitrypanosomal drugs. Proc. Natl. Acad. Sci. U. S. A. 87:950-954.
23. Shapiro, T. A., V. A. Klein, and P. T. Englund. 1989. Drug-promoted cleavage of kinetoplast DNA minicircles. Evidence for type II topoisomerase activity in trypanosome mitochondria. J. Biol. Chem. 264:4173-4178.
24. Shen, L. L. 2001. DNA-unwinding test using eukaryotic DNA topoisomerase I, p. 149-160. In N. Osheroff and M. Bjornsti (ed.), DNA topoisomerase protocols, part II. Enzymology & drugs. Humana Press Inc., Totowa, NJ.
25. Steverding, D. 2008. The history of African trypanosomiasis. Parasit. Vectors 1:3.
26. Taylor, J. R. 1997. Rejection of data, p. 165-172. In A. McGuire (ed.), An introduction to error analysis: the study of uncertainties in physical measurements. University Science Books, Sausalito, CA.
27. Trask, D. K., J. A. DiDonato, and M. T. Muller. 1984. Rapid detection and isolation of covalent DNA/protein complexes: application to topoisomerase I and II. EMBO J. 3:671-676.
28. Wang, J. C. 2002. Cellular roles of DNA topoisomerases: a molecular perspective. Nat. Rev. Mol. Cell Biol. 3:430-440.
29. Zweygarth, E., R. Kaminsky, P. D. Sayer, and S. van Nieuwenhove. 1990. Synergistic activity of 5-substituted 2-nitroimidazoles (Ro 15-0216 and benznidazole) and DL-alpha-difluoromethylornithine on Trypanosoma brucei brucei. Ann. Soc. Belg. Med. Trop. 70:269-279.