Limited but heterogeneous osteogenic response of human bone marrow mesenchymal stem cells to bone morphogenetic protein-2 and serum

Growth Factors

Volumn 28, Issue 1, 2010, Pages 34-43

  Mizuno, Daiki ^a   Agata, Hideki ^b,c   Furue, Hiroki ^a   Kimura, Ayuko ^d   Narita, Yuji ^d   Watanabe, Nobukazu ^e   Ishii, Yumiko ^e   Ueda, Minoru ^a   Tojo, Arinobu ^b   Kagami, Hideaki ^b  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^d NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

Author keywords

ALP activity; BMP 2; Bone regeneration; Mesenchymal stem cells; Tissue engineering

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; DEXAMETHASONE; FOLLISTATIN; NOGGIN; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2;

ADULT; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE REGENERATION; CELL DIFFERENTIATION; CELL LINE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MALE; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SERUM; SIGNAL TRANSDUCTION;

ADULT; ALKALINE PHOSPHATASE; ANIMALS; BONE MARROW CELLS; BONE MORPHOGENETIC PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; DEXAMETHASONE; FEMALE; FEMUR; HUMANS; MALE; MESENCHYMAL STEM CELLS; MICE; MICE, INBRED BALB C; OSTEOBLASTS; OSTEOGENESIS; RECOMBINANT PROTEINS; SERUM; TRANSFORMING GROWTH FACTOR BETA; YOUNG ADULT;

EID: 75749118479     PISSN: 08977194     EISSN: 10292292     Source Type: Journal    
DOI: 10.3109/08977190903326362     Document Type: Article

References (19)

1. Agata H, Asahina I, Yamazaki Y, Uchida M, Shinohara Y, Honda M, Kagami H, Ueda M. 2007. Effective bone engineering using periosteum-derived cells. J Dent Res 86:79-83.
2. Canalis E, Economides AN, Gazzerro E. 2003. Bone morphogenetic proteins, their antagonists, and the skeleton. Endocr Rev 24: 218-235.
3. Chen D, Zhao M, Mundy GR. 2004. Bone morphogenetic proteins. Growth Factors 22:233-241.
4. Diefenderfer DL, Osyczka AM, Reilly GC, Leboy PS. 2003. BMP responsiveness in human mesenchymal stem cells. Connect Tissue Res 44:305-311.
5. Friedman MS, Long MW, Hankenson KD. 2006. Osteogenic differentiation of human mesenchymal stem cells is regulated by bone morphogenic protein-6. J Biol Chem 98:538-554.
6. Jamali M, Karamboulas C, Rogerson PJ, Skerjanc IS. 2001. BMP signaling regulates Nkx2-5 activity during cardiomyogenesis. FEBS Lett 509:126-130. (Pubitemid 33153094)
7. Kwong FN, Harris MB. 2008. Recent developments in the biology of fracture repair. J Am Acad Orthop Surg 16:619-625.
8. Kwong FNK, Richardson SM, Evans CH. 2008. Chordin knockdown enhances the osteogenic differentiation of human mesenchymal stem cells. Arthritis Res Ther 10:R65.
9. Osyczka AM, Diefenderfer DL, Bhargave G, Leboy PS. 2004. Different effects of BMP-2 on marrow stromal cells from human and rat bone. Cell Tissues Organs 176:109-119.
10. Osyczka AM, Leboy PS. 2005. Bone morphogenetic protein regulation of early osteoblast genes in human marrow stromal cells is mediated by extracellular signal-regulated kinase and phospha tidylinositol 3-kinase signaling. Endocrinology 146: 3428-3437.
11. Reilly GC, Radin S, Chen AT, Ducheyne P. 2007. Differential alkaline phosphatase responses of rat and human bone marrow derived mesenchymal cells to 45S5 bioactive glass. Biomaterials 28:4091-4097.
12. Rifas L. 2007. The role of noggin in human mesenchymal stem cell differentiation. J Cell Biochem 100:824-838.
13. Singhatanadgit W, Mordan N, Salih V, Olsen I, Changes in bone morphogenic protein receptor-IB localization regulate osteogenic responses of human bone cells to bone morphogenic protein-2. Int J Biochem Cell Biol 2008;40:2854-2864.
14. ten Dijke P. 2006. Bone morphogenetic protein signal transduction in bone. Curr Med Res Opin 22(Suppl 1):S7-11.
15. Tsutsumi S, Shimazu A, Miyazaki K, Pan H, Koike C, Yoshida E, Takagishi K, Kato Y. 2001. Retention of multilineage differentiation potential of mesenchymal cells during proliferation in response to FGF. Biochem Biophys Res Commun 288: 413-419.
16. Urist MR. 1965. Bone: Formation by autoinduction. Science 150: 893-899.
17. Valenzuela DM, Economides AN, Rojas E, Lamb TM, Nunez L, Jones P, Lp NY, Espinosa R, III, Brannan CI, Gilbert DJ, Copeland NG, Jenkins NA, Lebeau MM, Harland RM, Yancopoulos GD. 1995. Identification of mammalian noggin and its expression in the adult nervous system. J Neurosci 15: 6077-6084.
18. Wan DC, Pomerantz JH, Brunet LJ, Kim J-B, Chou F-Y, Wu BM, Harland R, Blau HM, Longaker MT. 2007. Noggin suppression enhances in vitro osteogenesis and accelerates in vivo bone formation. J Biol Chem 282:26450-26459.
19. Warren SM, Brunet LJ, Harland RM, Economides AN, Longaker MT. 2003. The BMP antagonist noggin regulates cranial suture fusion. Nature 422:625-629.