Effects of posture on regional pulmonary blood flow in rats as measured by PET

Journal of Applied Physiology

Volumn 108, Issue 2, 2010, Pages 422-429

  Richter, Torsten ^a   Bergmann, Ralf ^b   Pietzsch, Jens ^b   Közle, Inge ^b   Hofheinz, Frank ^c   Schiller, Eik ^d   Ragaller, Maximilian ^a   Van Den Hoff, Jörg ^b  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^b INSTITUTE OF ION BEAM PHYSICS AND MATERIALS RESEARCH   (Germany)

^c ABX   (Germany)

^d ROTOP Pharmaka   (Germany)

Author keywords

68Ga radiolabel; Human serum albumin microspheres; Positron emission tomography; Prone position; supine position; Pulmonary blood flow; Small animal

Indexed keywords

DIAGNOSTIC AGENT; GALLIUM; MICROSPHERE;

ANIMAL; ARTICLE; BODY POSTURE; CAPILLARY; COMPUTER PROGRAM; DRUG EFFECT; IMAGE PROCESSING; LUNG; LUNG CIRCULATION; MALE; PHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; RAT; SCINTISCANNING; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SUPINE POSITION; THORAX; TISSUE DISTRIBUTION; WISTAR RAT;

ANIMALS; CAPILLARIES; GALLIUM RADIOISOTOPES; IMAGE PROCESSING, COMPUTER-ASSISTED; LUNG; MALE; MICROSPHERES; POSITRON-EMISSION TOMOGRAPHY; POSTURE; PRONE POSITION; PULMONARY CIRCULATION; RATS; RATS, WISTAR; SOFTWARE; SUPINE POSITION; THORAX; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 75749115587     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.91257.2008     Document Type: Article

References (41)

1. Albert RK, Hubmayr RD. The prone position eliminates compression of the lungs by the heart. Am J Respir Crit Care Med 161: 1660-1665, 2000.
2. Altemeier WA, McKinney S, Krueger M, Glenny RW. Effect of posture on regional gas exchange in pigs. J Appl Physiol 97: 2104-2111, 2004.
3. Beck KC. Regional trapping of microspheres in the lung compares well with regional blood flow. J Appl Physiol 63: 883-889, 1987.
4. Beck KC, Rehder K. Differences in regional vascular conductances in isolated dog lungs. J Appl Physiol 61: 530-538, 1986.
5. Bernard SL, Ewen JR, Barlow CH, Kelly JJ, McKinney S, Frazer DA, Glenny RW. High spatial resolution measurements of organ blood flow in small laboratory animals. Am J Physiol Heart Circ Physiol 279: H2043H2052, 2000.
6. Beyer GJBR, Bergmann R, Bauer R, Hoyer D, Schubert H. In vivo stability of DTPA-HAS-microspheres labelled with radio-lanthanoids. Nuc Compact Eur/Am Commun Nucl Med 20: 54-58, 1989.
7. Chesler DA, Hales C, Hnatowich DJ, Hoop B. Three-dimensional reconstruction of lung perfusion image with positron detection. J Nucl Med 16: 80-82, 1975.
8. Chon D, Beck KC, Larsen RL, Shikata H, Hoffman EA. Regional pulmonary blood flow in dogs by 4D-X-ray CT. J Appl Physiol 101: 1451-1465, 2006.
9. Conhaim RL, Rodenkirch LA. Functional diameters of alveolar microvessels at high lung volume in zone II. J Appl Physiol 85: 47-52, 1998.
10. Conhaim RL, Watson KE, Heisey DM, Leverson GE, Harms BA. Perfusion heterogeneity in rat lungs assessed from the distribution of 4-microm-diameter latex particles. J Appl Physiol 94: 420-428, 2003.
11. Delgado A, Soriano I, Sanchez E, Oliva M, Evora C. Radiolabelled biodegradable microspheres for lung imaging. Eur J Pharm Biopharm 50: 227-236, 2000.
12. Dworkin HJ, Gutkowski RF, Porter W, Potter M. Effect of particle number on lung perfusion images: concise communication. J Nucl Med 18: 260-262, 1977.
13. Glenny RW, Bernard SL, Lamm WJ. Hemodynamic effects of 15microm-diameter microspheres on the rat pulmonary circulation. J Appl Physiol 89: 499-504, 2000.
14. Glenny RW, Bernard SL, Robertson HT. Pulmonary blood flow remains fractal down to the level of gas exchange. J Appl Physiol 89: 742-748, 2000.
15. Glenny RW, Lamm WJ, Albert RK, Robertson HT. Gravity is a minor determinant of pulmonary blood flow distribution. J Appl Physiol 71: 620-629, 1991.
16. Hopkins SR, Henderson AC, Levin DL, Yamada K, Arai T, Buxton RB, Prisk GK. Vertical gradients in regional lung density and perfusion in the supine human lung: the Slinky effect. J Appl Physiol 103: 240-248, 2007.
17. Jones AT, Hansell DM, Evans TW. Pulmonary perfusion in supine and prone positions: an electron-beam computed tomography study. J Appl Physiol 90: 1342-1348, 2001.
18. Kuwahira I, Moue Y, Ohta Y, Mori H, Gonzalez NC. Distribution of pulmonary blood flow in conscious resting rats. Respir Physiol 97: 309-321, 1994.
19. Lai YL, Hildebrandt J. Respiratory mechanics in the anesthetized rat. J Appl Physiol 45: 255-260, 1978.
20. Lamm WJ, Bernard SL, Wagner WW Jr, Glenny RW. Intravital microscopic observations of 15-microm microspheres lodging in the pulmonary microcirculation. J Appl Physiol 98: 2242-2248, 2005.
21. Lamm WJ, Hildebrandt JR, Hildebrandt J, Lai YL. End-expiratory volume in the rat: effects of consciousness and body position. J Appl Physiol 53: 1071-1079, 1982.
22. Mintun MA, Ter-Pogossian MM, Green MA, Lieh LL, Schuster DP. Quantitative measurement of regional pulmonary blood flow with positron emission tomography. J Appl Physiol 60: 317-326, 1986.
23. Musch G, Layfield JD, Harris RS, Melo MF, Winkler T, Callahan RJ, Fischman AJ, Venegas JG. Topographical distribution of pulmonary perfusion and ventilation, assessed by PET in supine and prone humans. J Appl Physiol 93: 1841-1851, 2002.
24. Musch G, Venegas JG. Positron emission tomography imaging of regional pulmonary perfusion and ventilation. Proc Am Thorac Soc 2: 522-527, 508-529, 2005.
25. Nyren S, Mure M, Jacobsson H, Larsson SA, Lindahl SG. Pulmonary perfusion is more uniform in the prone than in the supine position: scintigraphy in healthy humans. J Appl Physiol 86: 1135-1141, 1999.
26. Pelletier N, Robinson NE, Kaiser L, Derksen FJ. Regional differences in endothelial function in horse lungs: possible role in blood flow distribution? J Appl Physiol 85: 537-542, 1998.
27. Petersson J, Rohdin M, Sanchez-Crespo A, Nyren S, Jacobsson H, Larsson SA, Lindahl SG, Linnarsson D, Neradilek B, Polissar NL, Glenny RW, Mure M. Posture primarily affects lung tissue distribution with minor effect on blood flow and ventilation. Respir Physiol Neurobiol 156: 293-303, 2007.
28. Polissar NL, Stanford DC, Glenny RW. The 400 microsphere per piece "rule" does not apply to all blood flow studies. Am J Physiol Heart Circ Physiol 278: H16-H25, 2000.
29. Prisk GK, Yamada K, Henderson AC, Arai TJ, Levin DL, Buxton RB, Hopkins SR. Pulmonary perfusion in the prone and supine postures in the normal human lung. J Appl Physiol 103: 883-894, 2007.
30. Raju AMR, Divekar KD, Narasimhan DVS, Rahalkar AD, Lal R, Sundarajan Kotrappa P. Human serum albumin microspheres for lung imaging-preparation and evaluation. Isotopenpraxis 2: 57-61, 1978.
31. Rhodes BA, Zolle I, Buchanan JW, Wagner HN Jr. Radioactive albumin microspheres for studies of the pulmonary circulation. Radiology 92: 1453-1460, 1969.
32. Richard JC, Janier M, Decailliot F, Le Bars D, Lavenne F, Berthier V, Lionnet M, Cinotti L, Annat G, Guerin C. Comparison of PET with radioactive microspheres to assess pulmonary blood flow. J Nucl Med 43: 1063-1071, 2002.
33. Richter T, Bellani G, Scott Harris R, Vidal Melo MF, Winkler T, Venegas JG, Musch G. Effect of prone position on regional shunt, aeration, and perfusion in experimental acute lung injury. Am J Respir Crit Care Med 172: 480-487, 2005.
34. Schiller E, Bergmann R, Pietzsch J, Noll B, Sterger A, Johannsen B, Wunderlich G, Pietzsch HJ. Yttrium-86-labelled human serum albumin microspheres: relation of surface structure with in vivo stability. Nucl Med Biol 35: 227-232, 2008.
35. Schuster DP, Kaplan JD, Gauvain K, Welch MJ, Markham J. Measurement of regional pulmonary blood flow with PET. J Nucl Med 36: 371-377, 1995.
36. Treppo S, Mijailovich SM, Venegas JG. Contributions of pulmonary perfusion and ventilation to heterogeneity in V(A)/Q measured by PET. J Appl Physiol 82: 1163-1176, 1997.
37. Tsuchiya M, Walsh GM, Frohlich ED. Systemic hemodynamic effects of microspheres in conscious rats. Am J Physiol Heart Circ Physiol 233: H617-H621, 1977.
38. Wagner SJ, Welch MJ. Gallium-68 labeling of albumin and albumin microspheres. J Nucl Med 20: 428-433, 1979.
39. Walther SM, Domino KB, Glenny RW, Hlastala MP. Pulmonary blood flow distribution in sheep: effects of anesthesia, mechanical ventilation, and change in posture. Anesthesiology 87: 335-342, 1997.
40. Wiener CM, McKenna WJ, Myers MJ, Lavender JP, Hughes JM. Left lower lobe ventilation is reduced in patients with cardiomegaly in the supine but not the prone position. Am Rev Respir Dis 141: 150-155, 1990.
41. Wunderlich G, Pinkert J, Stintz M, Kotzerke J. Labeling and biodistribution of different particle materials for radioembolization therapy with 188Re. Appl Radiat Isot 62: 745-750, 2005.