Pulmonary blood flow distribution in sheep: Effects of anesthesia, mechanical ventilation and change in posture

Anesthesiology

Volumn 87, Issue 2, 1997, Pages 335-342

  Walther, Sten M ^a   Domino, Karen B ^a   Glenny, Robb W ^a   Hlastala, Michael P ^a  

^a Department of Anaesthesia ^*

Author keywords

Anesthesia: Pentobarbital; Body position; Breathing: mechanical ventilation; Lung, blood flood: perfusion gradient, perfusion heterogeneity; Measurement technique: fluorescent microspheres; Prone, supine

Indexed keywords

MICROSPHERE; PENTOBARBITAL;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL VENTILATION; BODY POSITION; BODY POSTURE; CONTROLLED STUDY; FEMALE; FLUORESCENCE; GAS EXCHANGE; GRAVITY; LUNG BLOOD FLOW; LUNG PERFUSION; LUNG WEIGHT; MALE; NONHUMAN; PRIORITY JOURNAL; SHEEP; SPECTROPHOTOMETRY; TOTAL LUNG CAPACITY;

NASA DISCIPLINE CARDIOPULMONARY; NON-NASA CENTER;

ANESTHETICS, INTRAVENOUS; ANIMALS; BLOOD GAS ANALYSIS; BLOOD PRESSURE; FEMALE; MALE; PENTOBARBITAL; POSTURE; PULMONARY CIRCULATION; RESPIRATION; RESPIRATION, ARTIFICIAL; SHEEP; WAKEFULNESS;

EID: 0030880906     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199708000-00021     Document Type: Article

References (20)

1. Hughes JMB, Glazier JB, Maloney JE, West JB: Effect of lung volume on the distribution of pulmonary blood flow in man. Respir Physiol 1968; 4:58-72
2. Beck KC, Rehder K: Differences in regional vascular conductances in isolated dog lungs. J Appl Physiol 1986; 61:530-8
3. Hakim TS, Lisbona R, Dean GW: Gravity independent inequality in regional pulmonary blood flow in humans. J Appl Physiol 1987; 63:1114-21
4. Glenny RW, Lamm WJE, Albert RK, Robertson HT: Gravity is a minor determinant of pulmonary blood flow distribution. J Appl Physiol 1991; 71:620-9
5. A/Q [Abstract]. FASEB J 1994; 8:A691
6. Glenny RW, Polissar L, Robertson HT: Relative contribution of gravity to pulmonary perfusion heterogeneity. J Appl Physiol 1991; 71:2449-52
7. Hulands GH, Greene R, Iliff LD, Nunn JF: Influence of anaesthesia on the regional distribution of perfusion and ventilation in the lung. Clin Sci 1970; 38:451-60
8. Landmark SJ, Knopp TJ, Rehder K, Sessler AD: Regional pulmonary perfusion and V/Q in awake and anesthetized-paralyzed man. J Appl Physiol 1977; 43:993-1000
9. Beck KC, Vetterman J, Rehder K: Gas exchange in dogs in the prone and supine positions. J Appl Physiol 1992; 72:2292-7
10. Terry PB, Menkes HA, Traystman RJ: Effects of maturation and aging on collateral ventilation in sheep. J Appl Physiol 1987; 62:1028-32
11. Melsom MN, Flatebo T, Kramer-Johansen J, Aulie A, Sjaastad OV, Iversen PO, Nicolaysen G: Both gravity and non-gravity dependent factors determine regional blood flow within the goat lung. Acta Physiol Stand 1995; 153:343-53
12. Glenny RW, Bernard S, Brinkley M: Validation of fluorescent-labeled microspheres for measurement of regional organ perfusion. J Appl Physiol 1993; 74:2585-97
13. Austin RE Jr, Hauck WW, Aldea GS, Flynn AE, Coggins DL, Hoffman JIE: Quantitating error in blood flow measurements with radioactive microspheres. Am J Physiol 1989; 257:H280-8
14. Liu S, Margulies SS, Wilson TA: Deformation of the dog lung in the chest wall. J Appl Physiol 1990; 68:1979-87
15. Walther S, Domino K, Glenny R, Polissar N, Hlastala M: Pulmonary blood flow distribution has a central-to-peripheral gradient in awake, prone sheep. J Appl Physiol 1997; 82:678-85
16. Parker JC, Ardell JL, Hamm CR, Barman SA, Coker PJ: Regional pulmonary blood flow during rest, tilt, and exercise in unanesthetized dogs. J Appl Physiol 1995; 78:838-46
17. Glenny RW, Robertson HT: Fractal properties of pulmonary blood flow: characterization of spatial heterogeneity. J Appl Physiol 1990; 69:532-45
18. Hlastala M, Mann C, Walther S Domino K: Effect of lobar pulmonary blood flow on flow heterogeneity Br J Anaesth 1996; 76(Suppl 2):48-9
19. Glenny RW, Robertson HT: A computer simulation of pulmonary perfusion in three dimensions. J Appl Physiol 1995; 79:357-69
20. Pappert D, Rossaint R, Slama K, Grüning, Falke KJ: Influence of positioning on ventilation-perfusion relationships in severe adult respiratory distress syndrome. Chest 1994; 106:1511-6