C Reactive Protein (CRP) as a predictor for true bacteremia in children

Medical Science Monitor

Volumn 14, Issue 5, 2008, Pages

  Shaoul, Ron ^a,b   Lahad, Avishai ^a   Tamir, Ada ^a   Lanir, Amos ^a   Srugo, Issac ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b BNAI ZION MEDICAL CENTER   (Israel)

Author keywords

Bacteremia; Blood culture; C reactive protein; Children; Infants

Indexed keywords

C REACTIVE PROTEIN;

ACUTE GASTROENTERITIS; ACUTE OTITIS MEDIA; ADOLESCENT; ADULT; ARTICLE; BACTEREMIA; BACTERIUM DETECTION; BACTERIUM IDENTIFICATION; BLOOD ANALYSIS; BLOOD CULTURE; CHILD; CLINICAL EVALUATION; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HUMAN; INFANT; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; NEUTROPHIL COUNT; NEWBORN; PATIENT SELECTION; PEDIATRIC WARD; PNEUMONIA; PROTEIN BLOOD LEVEL; RETROSPECTIVE STUDY; URINARY TRACT INFECTION;

ADOLESCENT; BACTEREMIA; C-REACTIVE PROTEIN; CHILD; CHILD, PRESCHOOL; GASTROENTERITIS; HUMANS; INFANT; INFANT, NEWBORN; LEUKOCYTE COUNT; NEUTROPHILS; OTITIS MEDIA; PNEUMONIA; SENSITIVITY AND SPECIFICITY; URINARY TRACT INFECTIONS;

EID: 43549113140     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Pulliam PN, Attia MW, Cronan KM: C-reactive protein in febrile children 1 to 36 months of age with clinically undetectable serious bacterial infection. Pediatrics, 2001; 108: 1275-79
2. Isaacman DJ, Shults J, Gross TK et al: Predictors of bacteremia in febrile children 3 to 36 months of age. Pediatrics, 2000; 106: 977-82
3. Kushner I, Gewurz H, Benson MD: C-reactive protein and the acutephase response. J Lab Clin Med, 1981; 97: 739-49
4. Steel DM, Whitehead AS: The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein. Immunol Today, 1994; 15: 81-88
5. Thompson D, Milford-Ward A, Whicher JT: The value of acute phase protein measurements in clinical practice. Ann Clin Biochem, 1992; 29 (Pt.2): 123-31
6. James K: Immunoserology of infectious diseases. Clin Microbiol Rev, 1990; 3: 132-52
7. Chandrasekar PH, Brown WJ: Clinical issues of blood cultures. Arch Intern Med, 1994; 154: 841-49
8. Eisenberg JM, Rose JD, Weinstein AJ: Routine blood cultures from febrile outpatients. Use in detecting bacteremia. JAMA, 1976; 236: 2863-65
9. Stair TO, Lenhart M: Outpatient blood cultures: retrospective and prospective audits in one ED. Ann Emerg Med, 1984; 13: 986-87
10. Segal GS, Chamberlain JM: Resource utilization and contaminated blood cultures in children at risk for occult bacteremia. Arch Pediatr Adolesc Med, 2000; 154: 469-73
11. Waltzman ML, Harper M: Financial and clinical impact of false-positive blood culture results. Clin Infect Dis, 2001; 33: 296-99
12. Mylotte JM, Tayara A: Blood cultures: clinical aspects and controversies. Eur J Clin Microbiol Infect Dis, 2000; 19: 157-63
13. Almirall J, Bolibar I, Toran P et al: Contribution of C-reactive protein to the diagnosis and assessment of severity of community-acquired pneumonia. Chest, 2004; 125: 1335-42
14. Benitz WE, Han MY, Madan A, Ramachandra P: Serial serum C-reactive protein levels in the diagnosis of neonatal infection. Pediatrics, 1998; 102: E41
15. Byl B, Deviere J, Saint-Hubert F et al: Evaluation of tumor necrosis factor-alpha, interleukin-6 and C-reactive protein plasma levels as predictors of bacteremia in patients presenting signs of sepsis without shock. Clin Microbiol Infect, 1997; 3: 306-16
16. Clarke D, Cost K: Use of serum C-reactive protein in differentiating septic from aseptic meningitis in children. J Pediatr, 1983; 102: 718-20
17. Hansson LO, Axelsson G, Linne T et al: Serum C-reactive protein in the differential diagnosis of acute meningitis. Scand J Infect Dis, 1993; 25: 625-30
18. Hellerstein S, Duggan E, Welchert E, Mansour F: Serum C-reactive protein and the site of urinary tract infections. J Pediatr, 1982; 100: 21-25
19. Honkinen O, Jahnukainen T, Mertsola J et al: Bacteremic urinary tract infection in children. Pediatr Infect Dis J, 2000; 19: 630-34
20. Hopstaken RM, Muris JW, Knottnerus JA et al: Contributions of symptoms, signs, erythrocyte sedimentation rate, and C-reactive protein to a diagnosis of pneumonia in acute lower respiratory tract infection. Br J Gen Pract, 2003; 53: 358-64
21. Isaacman DJ, Burke BL: Utility of the serum C-reactive protein for detection of occult bacterial infection in children. Arch Pediatr Adolesc Med, 2002; 156: 905-9
22. Jaye DL, Waites KB: Clinical applications of C-reactive protein in pediatrics. Pediatr Infect Dis J, 1997; 16: 735-46
23. Korczowski B, Szybist W: Serum procalcitonin and C-reactive protein in children with diarrhoea of various aetiologies. Acta Paediatr, 2004; 93: 169-73
24. Korppi M, Heiskanen-Kosma T, Leinonen M: White blood cells, C-reactive protein and erythrocyte sedimentation rate in pneumococcal pneumonia in children. Eur Respir J, 1997; 10: 1125-29
25. Mangiarotti P, Moulin F, Palmer P et al: Interferon-alpha in viral and bacterial gastroenteritis: a comparison with C-reactive protein and interleukin-6. Acta Paediatr, 1999; 88: 592-94
26. Peltola H, Jaakkola M: C-reactive protein in early detection of bacteremic versus viral infections in immunocompetent and compromised children. J Pediatr, 1988; 113: 641-46
27. Tejani NR, Chonmaitree T, Rassin DK et al: Use of C-reactive protein in differentiation between acute bacterial and viral otitis media. Pediatrics, 1995; 95: 664-69
28. Virkki R, Juven T, Rikalainen H et al: Differentiation of bacterial and viral pneumonia in children. Thorax, 2002; 57: 438-41
29. McCabe RE, Remington JS: C-reactive protein in patients with bacteremia. J Clin Microbiol, 1984; 20: 317-19
30. Pitetti RD, Choi S: Utility of blood cultures in febrile children with UTI. Am J Emerg Med, 2002; 20: 271-74
31. Eda S, Kaufmann J, Roos W, Pohl S: Development of a new microparticle-enhanced turbidimetric assay for C-reactive protein with superior features in analytical sensitivity and dynamic range. J Clin Lab Anal, 1998; 12: 137-44
32. Reimer LG, Wilson ML, Weinstein MP: Update on detection of bacteremia and fungemia. Clin Microbiol Rev, 1997; 10: 444-65
33. McGowan KL, Foster JA, Coffin SE: Outpatient pediatric blood cultures: time to positivity. Pediatrics, 2000; 106(2 Pt 1): 251-55
34. Kornberg AE, Jain N, Dannenhoffer R: Evaluation of false positive blood cultures: guidelines for early detection of contaminated cultures in febrile children. Pediatr Emerg Care, 1994; 10: 20-22
35. Richter SS, Beekmann SE, Croco JL et al: Minimizing the workup of blood culture contaminants: implementation and evaluation of a laboratory-based algorithm. J Clin Microbiol, 2002; 40: 2437-44
36. St GJ III, Bell LM, Baumgart S et al: Distinguishing sepsis from blood culture contamination in young infants with blood cultures growing coagulase-negative staphylococci. Pediatrics, 1990; 86: 157-62
37. Krause R, Haberl R, Wolfler A et al: Molecular typing of coagulase-negative staphylococcal blood and skin culture isolates to differentiate between bacteremia and contamination. Eur J Clin Microbiol Infect Dis, 2003; 22: 760-63
38. Trautner BW, Clarridge JE, Darouiche RO: Skin antisepsis kits containing alcohol and chlorhexidine gluconate or tincture of iodine are associated with low rates of blood culture contamination. Infect Control Hosp Epidemiol, 2002; 23: 397-401
39. Ramsook C, Childers K, Cron SG, Nirken M: Comparison of bloodculture contamination rates in a pediatric emergency room: newly inserted intravenous catheters versus venipuncture. Infect Control Hosp Epidemiol, 2000; 21: 649-51
40. Surdulescu S, Utamsingh D, Shekar R: Phlebotomy teams reduce blood-culture contamination rate and save money. Clin Perform Qual Health Care, 1998; 6: 60-62
41. Shortland DB, MacFadyen U, Elston A, Harrison G: Evaluation of C reactive protein values in neonatal sepsis. J Perinat Med, 1990; 18: 157-63
42. Baraff LJ, Schriger DL, Bass JW et al: Practice Guideline for the Management of Infants and Children 0 to 36 Months of Age With Fever Without Source. Pediatrics, 1993; 92: 1-12
43. Bates DW, Goldman L, Lee TH: Contaminant blood cultures and resource utilization. The true consequences of false-positive results. JAMA, 1991; 265: 365-69