The anti-HIV actions of 7- And 10-substituted camptothecins

Molecules

Volumn 15, Issue 1, 2010, Pages 138-148

  Li, Yu Ye ^a,c,d,e   Chen, Shi Wu ^b   Yang, Liu Meng ^a   Wang, Rui Rui ^a   Pang, Wei ^a   Zheng, Yong Tang ^a  

^a KUNMING INSTITUTE OF ZOOLOGY   (China)

^b LANZHOU UNIVERSITY   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^d KUNMING MEDICAL UNIVERSITY   (China)

^e Yunnan Institute of Dermatology and Venereology   (China)

Author keywords

Anti HIV agents; Camptothecin; HIV

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CAMPTOTHECIN; DRUG DERIVATIVE;

ARTICLE; CELL DEATH; CHEMISTRY; DRUG EFFECT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2;

ANTI-HIV AGENTS; CAMPTOTHECIN; CELL DEATH; HIV-1; HIV-2; HUMANS;

EID: 75749090417     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules15010138     Document Type: Article

References (19)

1. Palella, F. J.; Delaney, K. M.; Moorman, A. C.; Loveless, M. O.; Fuhrer, J.; Satten, G. A.; Aschman, D. J.; Holmberg, S. D. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl. J. Med. 1998, 338, 853-860.
2. Grant, R. M.; Hecht, F. M.; Warmerdam, M.; Liu, L.; Liegler, T.; Petropoulos, C. J.; Hellmann, N. S.; Chesney, M.; Busch, M. P.; Kahn, J. O. Time trends in primary HIV-1 drug resistance among recently infected persons. JAMA 2002, 288, 181-188.
3. Wall, M. E.; Wani, M. C.; Cook, C. E.; Palmer, K. H.; McPhail, A. T.; Sim, G. A. Plant antitumor agents. I. The isolation and structure of Camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata. J. Am. Chem. Soc. 1966, 88, 3888-3890.
4. 4. Sadaie, M. E.; Mayner, R.; Doniger, J. A novel approach to develop anti-HIV drugs: Adapting non-nucleoside anticancer chemotherapeutics. Antiviral. Res. 2004, 61, 1-18. (Pubitemid 37508525)
5. Hsiang, Y. H.; Hertzberg, R.; Hecht, S.; Liu, L. F. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J. Biol. Chem. 1985, 260, 14873-14878.
6. 6. Shao, R. G.; Cao, C. X.; Nieves-Neira, W.; Dimanche-Boitrel, M. T.; Solary, E.; Pommier, Y. Activation of the Fas pathway independently of Fas ligand during apoptosis induced by camptothecin in p53 mutant human colon carcinoma cells. Oncogene 2001, 20, 1852-1859. (Pubitemid 32458695)
7. Pantazis, P. Camptothecin: A promising antiretroviral drug. J. Biomed. Sci. 1996, 3, 14-19.
8. 8. Sadaie, M. R.; Doniger, J.; Hung, C. L.; Pantazis, P. 9-nitrocamptothecin selectively inhibits human immunodeficiency virus type 1 replication in freshly infected parental but not 9-nitrocamptothecin-resistant U937 monocytoid cells. AIDS Res. Hum. Retrovirus. 1999, 15, 239-245. (Pubitemid 29101925)
9. 9. Royal, W.; Dupont, B.; McGuire, D.; Chang, L.; Goodkin, K.; Ernst, T.; Post, MJ.; Fish, D.; Pailloux, G.; Poncelet, H.; Concha, M.; Apuzzo, L.; Singer, E. Topotecan in the treatment of acquired immunodeficiency syndrome-related progressive multifocal leukoencephalopathy. J. Neurovirology 2003, 9, 411-419. (Pubitemid 36874717)
10. Earp, L. J.; Delos, S. E.; Park, H. E.; White, J. M. The many mechanisms of viral membrane fusion proteins. Curr. Top. Microbiol. Immunol. 2005, 285, 25-66.
11. Hung, C. L.; Doniger, J.; Palini, A.; Snyder, S. W.; Radonovich, M. F.; Brady, J. N.; Pantazis, P.; Sadaie, M. R. 9-nitrocamptothecin inhibits HIV-1 replication in human peripheral blood lymphocytes: A potential alternative for HIV-infection/AIDS therapy. J. Med. Virol. 2001, 64, 238-244.
12. Moulton, S.; Pantazis, P.; Epstein, J. S.; Sadaie, M. R. 9-Nitrocamptothecin inhibits tumor recrosis factor-mediated activation of human immunodeficiency virus type 1 and enhances apoptosis in a latently infected T cell clone. AIDS Res. Hum. Retroviruses 1998, 14, 39-49.
13. Wall, M. E.; Wani, M. C; Nicholas, A. W.; Manikumar, C.; Tele, C.; Moore, L.; Truesdale, A.; Leitner, P.; Besterman, J. M. Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs. J. Med. Chem. 1993, 36, 2689-2700.
14. Sawada, S; Nokata, K.; Furuta, T.; Yokokura, T.; Miyasaka, T. Chemical modification of an antitumor alkaloid camptothecin: synthesis and antitumor activity of 7-C-substituted camptothecins. Chem. Pharm. Bull. (Tokyo) 1991, 39, 2574-3580.
15. Zhang, G. H.; Wang, Q.; Chen, J. J.; Zhang, X. M.; Tam, S. C.; Zheng, Y. T. The anti-HIV-1 effect of scutellarin. Biochem. Biophys. Res. Commun. 2005, 334, 812-816.
16. Zheng, YT.; Zhang, W. F.; Ben, K. L.; Wang, J. H. In vitro immunotoxicity and cytotoxicity of trichosanthin against human normal immunocytes and leukemia-lymphoma cells. Immunopharmacol. Immunotoxicol. 1995, 17, 69-79.
17. Wang, Q.; Ding, Z. H.; Liu, J. K.; Zheng, Y. T. Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus. Antiviral. Res. 2004, 64, 189-194.
18. Wang, Y. H.; Wang, R. R.; Yang, L. M.; li, J. F.; Xu, W. M.; Zheng, Y. T. Expression, purification of HIV-1 protease and the establishment of a method for protease inhibitor screening. Virol. Sin. 2006, 21, 126-130.
19. Wang, Y. H.; Tang, J. G.; Wang, R. R.; Yang, L. M.; Dong, Z. J.; Du, L.; Shen, X.; Liu, J. K.; Zheng, Y. T. Flazinamide, a novel beta-carboline compound with anti-HIV actions. Biochem. Biophys. Res. Commun. 2007, 355, 1091-1095.