Functional evidence confirmed by histological localization: Overlapping expression of erythropoietin and HIF-2α in interstitial fibroblasts of the renal cortex

Kidney International

Volumn 77, Issue 4, 2010, Pages 269-271

  Castrop, Hayo ^a   Kurtz, Armin ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 2ALPHA; VON HIPPEL LINDAU PROTEIN;

CELL NUCLEUS; CELLULAR DISTRIBUTION; ERYTHROPOIESIS; FIBROBLAST; GENE DELETION; GENETIC TRANSCRIPTION; KIDNEY CORTEX; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; TISSUE DISTRIBUTION;

EID: 75749090032     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2009.470     Document Type: Note

References (14)

1. Maxwell PH, Osmond MK, Pugh CW et al. Identification of the renal erythropoietin-producing cells using transgenic mice. Kidney Int 1993; 44: 1149-1162.
2. Maxwell PH, Ferguson DJ, Osmond MK et al. Expression of a homologously recombined erythopoietin-SV40 T antigen fusion gene in mouse liver: evidence for erythropoietin production by Ito cells. Blood 1994; 84: 1823-1830.
3. Ivan M, Kondo K, Yang H et al. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 2001; 292: 464-468.
4. Semenza GL. Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 1999; 15: 551-578.
5. Wiesener MS, Jurgensen JS, Rosenberger C et al. Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs. FASEB J 2003; 17: 271-273.
6. Scortegagna M, Morris MA, Oktay Y et al. T h e H I F family member EPAS1/HIF-2alpha is required for normal hematopoiesis in mice. Blood 2003; 102: 1634-1640.
7. Gruber M, Hu CJ, Johnson RS et al. Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci USA 2007; 104: 2301-2306.
8. Peng J, Zhang L, Drysdale L, Fong GH. The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. Proc Natl Acad Sci USA 2000; 97:8386-8391.
9. Scortegagna M, Ding K, Zhang Q et al. HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner. Blood 2005; 105: 3133-3140.
10. Bachmann S, Le Hir M, Eckardt KU. Co-localization of erythropoietin mRNA and ecto-5'-nucleotidase immunoreactivity in peritubular cells of rat renal cortex indicates that fibroblasts produce erythropoietin J Histochem Cytochem 1993; 41: 335-341.
11. RosenbergerC, MandriotaS,JurgensenJSet al. Expression of hypoxia-inducible factor-1alpha and-2alpha in hypoxic and ischemic rat kidneys. J Am Soc Nephrol2002; 13:1721-1732.
12. Paliege A, Rosenberger C, Bondke A et al. Hypoxia-inducible factor-2a-expressing interstitial fibroblasts are the only renal cells that express erythropoietin under hypoxia-inducible factor stabilization. Kidney Int 2010; 77:312-318.
13. Stolze I, Berchner-Pfannschmidt U, Freitag P et al. Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells. Blood 2002; 100: 2623-2628.
14. Grimm C Wenzel A, Groszer M et al. HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration. Nat Med 2002; 8: 718-724.